Yasar Arfat T Kasu

@SignerLab @ISEHSociety Congratulations Rob🥳🥳!!! Absolutely deserving⭐️🤩

Honored & grateful to deliver the #ISEH2024 Janet Rowley Award Lecture this morning. Excited to talk about our team, their discoveries & what amazing humans they are. Huge thank you to @ISEHSociety, our @SignerLab team, family, friends, mentors, colleagues & funders. 🙏

Ribosomes take a break from their usual role go.nature.com/4bV9NAl

Can anti-aging antibodies revive the immune system? In @NatureNV we previewed the latest breakthrough from Irv Weissman's team in @Nature that used immunotherapy to deplete aging stem cells. @KasuYasar nature.com/articles/d4158…

🆕 @Nature Rejuvenating the aged immune system with antibody depletion of blood myeloid stem cells @justsaysinmice nature.com/articles/s4158… nature.com/articles/d4158… @HOSTvsVirus @SignerLab @KasuYasar Big implications

@jasmeetkvirdi @Prasad24330246 This is gr8!!! Congratulations🤩🥳

The satisfaction of seeing your #PhD work in publication is beyond words. Excited to share that my research article with Dr. Prasad Pethe @Prasad24330246 is published online in Cell Biology International journal!! onlinelibrary.wiley.com/doi/abs/10.100…

@DrAveritt @djc1901 Congrarulations Daisy🤩🤩🤩

Big congrats to @djc1901 on officially getting her PhD today, so proud of you Dr. Cantu!!!

Did you ever wonder why our marrow is located inside of our *bones*, #MedTwitter? There’s no a priori anatomical reason it should be sited there. Blood cells could form in our spleens & livers, as they do during our fetal lives; or elsewhere, as in some animals. Let’s discuss! /1

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

@ParamitaBasu21 @PittAnes @PCPRpgh Awesome newzz!!!!🤩🤩🤩 Congratulations😀

Excited to share that I am starting as a Research Assistant Professor at the University of Pittsburgh’s Dept. of Anesthesiology!! Grateful to my mentors, especially Camelia Maier, Dayna, and Brad, for their support and encouragement. @PittAnes @PCPRpgh

Out now! Unveiling the mystery of TRiC/CCT chaperonin assembly! 🥳Our paper uncovers how its unique double-ring architecture forms through a step-by-step hierarchy. Many congrats to the first authors @mirandacollier @KarenBetaMor! 😍 Check out more here: sciencedirect.com/science/articl…

Chandrayaan-3 Mission: 'India🇮🇳, I reached my destination and you too!' : Chandrayaan-3 Chandrayaan-3 has successfully soft-landed on the moon 🌖!. Congratulations, India🇮🇳! #Chandrayaan_3 #Ch3

A mind-blowing paper has come out today in @Nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome. The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution. Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell. When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part. The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival. The conclusion of the paper is metaphorically a quote from the Jurassic Park movie: “Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (scienmag.com/artificial-cel…) nature.com/articles/s4158…

Ribo-ITP enables ribosome occupancy measurements from single cells. Our first application revealed insights into allele-specific ribosome engagement in early development (nature.com/articles/s4158…). #RiboITP #singlecell

Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control Cell cell.com/cell/fulltext/…

Happy to be part of this fun collaboration with Nick Baker- in this study led by @FolgadoVirginia and Kristina Ames we show that the ribosomal protein RpS12 is required for skeletal development and hematopoiesis in mice doi.org/10.7554/eLife.…

@DrAveritt @txwomans 🤩🤩🤩🤩 congratulations @RituparnaSinha9 😍, Ann Davenport and Mengie Cao🥳

TWU Biology Rocks! @txwomans

For 50 years we've known that recycling helps keep our planet healthy. Now we know it's also essential to boost stem cell fitness & longevity.

@DrGTWU @Farhanlakdawal4 @TWU_CAS 🎉🎉🎉 great addition to @abbvie!!

“To live is to find out for yourself the truth.” Jiddu Krishnamurti (1895 – 1986) ⁦@Farhanlakdawal4⁩ has started the next step of his research career. I’m so glad to have mentored him for his PhD work ⁦⁦@TWU_CAS⁩, and that he’ll keep finding out answers at Abbvie!

@TWUGradDean @GradSchoolTwu @txwomans 🎉🎉🎉🎉 @Farhanlakdawal4 and @AkshayaArva !!!

So proud of these doctoral grads! TWU Denton ceremony 2. @GradSchoolTwu @txwomans #TWUGRAD22 #PhDone

Breakdown of PhD student cost on a grant: tuition $45K stipend $35K fringe $10K indirects $60K -- total paid by NIH to university: $150K total paid by university to student: $35K (this is just a toy example to illustrate a point, not real numbers but same ballpark)