Kenneth Yaw Agyeman-Badu

A Wonderful New Day beginning a Wonderful New Week, have a Blissful One & keep that Smile. ☺😃 #Scientists #Gamers

I reached a new Milestone on @TrueAchievement: 855 Completed Games trueachievements.com/gamer/Kenzibit…

I reached a new Milestone on @TrueAchievement: 2,300,000 TrueAchievement Score trueachievements.com/gamer/Kenzibit…

I reached a new Milestone on @TrueAchievement: 1,800,000 GamerScore trueachievements.com/gamer/Kenzibit…

@camalonious Some perfect birthday gift, go for it man 👍🏾

I'm turning 35 in a couple of weeks and decided - screw it - I deserve this. 🔫 *laughs in British*

@CallmeGerbz Nice one, at 431 and my back hurts 😂

I DID IT

@PatrickMaka @GreenVelvet001 At this time I have just given up on this. I even entered the garage, close to the house, side of the house and still nothing 😂😂 pressing RB and A to take photos, saving them etc.

@Kenzibit @GreenVelvet001 You gotta park really close to the house…? Worked for me without an issue.

There's a glitch in Forza Horizon 6 where it'll complete the daily challenges when you do them even if they're still locked. As a result, you can complete the week early and do it today instead of waiting for Wednesday.

@yobson8 @PatrickMaka Same here, and the only one left.

@PatrickMaka the take a picture with a Toyota at Mei's house is the only one that didn't work for me, I tried inside and outside and it didn't give me the point

@PatrickMaka @GreenVelvet001 Any tips on the take photo on any Toyota at Mei's House works? Tried everything and it's the only one I got left.

@GreenVelvet001 You just do them… There’s not really much else to it. It’s not an exploit or anything.

De Novoでケトリダクターゼを創出。しかも残基数はたったの130。日本もこういう分野で強みを発揮したいが、相当出遅れている印象 pubs.acs.org/doi/10.1021/ja…

Forza Horizon 6 is officially the first racing game GOTY contender in history polygon.com/forza-horizon-…

NVIDIA and AMD CEOs have landed in Taiwan as they prepare to unveil their next-gen lineups at Computex 2026. wccftech.com/nvidia-jensen-…

absolute cinema

We tested Advanced Shader Delivery on the RX 9070 XT in six games — up to 95% improvement in load times and 33 percent faster 1% Low FPS tomshardware.com/pc-components/…

Priority first

How an inverse-folding neural network rescued a gene-editing protein from its own evolution Prime editors are among the most precise CRISPR-based tools. They rewrite small stretches of DNA without cutting both strands, which makes them safer than older nucleases and a strong candidate for treating point-mutation diseases. The active part is a reverse transcriptase (RT), an enzyme that copies the desired edit from an RNA guide into the genome. Years of laboratory evolution in bacteria have made this RT faster. But there is a catch known across protein engineering: mutations that improve activity often weaken the folded structure. The evolved RT works better per molecule, yet less of it folds correctly inside human cells, which matters when the editor is delivered transiently as mRNA in a lipid nanoparticle. Y. Allen Tao and coauthors use a different toolkit. They turn to ProteinMPNN, a graph neural network trained on solved protein structures to do inverse folding: given a 3D backbone, propose amino acid sequences likely to fold into it stably. Starting from AlphaFold3 structures of four evolved RTs, they mask two sets of residues the network cannot change. The first sits within 15 to 20 angstroms of the DNA-RNA substrate, protecting the catalytic core. The second is conserved across natural homologs. ProteinMPNN proposes new sequences for everything else, and AlphaFold2 screens each candidate by structural confidence (pLDDT) and similarity to the parent fold. The numbers are striking. Redesigned variants carry 30 to 163 substitutions, yet 95% still edit DNA above 5%. The best variant gains 8 degrees C in melting temperature, and intracellular editor protein roughly doubles after mRNA delivery. Across 700 pathogenic ClinVar mutations, average correction improves 2.3- to 2.5-fold over evolved starting points. In mice receiving editors against the cholesterol gene Pcsk9, liver editing rises up to 2.9-fold, with no detectable off-target activity. For gene therapy and biopharma, the lesson is methodological. Directed evolution and AI redesign optimize different properties, and combining them is now a concrete recipe. Higher expression per dosed molecule means lower doses, wider safety margins, and a path to editors that work in tissues where transient delivery used to fail. Paper: Tao et al., Nature Biotechnology (2026) — CC BY-NC-ND 4.0 | doi.org/10.1038/s41587…

I reached a new Milestone on @TrueAchievement: 1,790,000 GamerScore trueachievements.com/gamer/Kenzibit…

First AI-generated RNA with novel atomically ordered 3D fold! With @eternagame @StanfordBiochem @chaitjo @PossuHuangLab @UWproteindesign @ShujunHe0717 @navtejtoor @HHMIJanelia on bioRxiv doi.org/10.64898/2026.…

Get yours today ✅

The 2026 ROG Strix SCAR 18 is for gamers who know the difference a display makes. Featuring the Intel® Core™ Ultra 9 290HX Plus and an 18-inch 4K ROG Nebula HDR Mini LED Display, it delivers the kind of immersive, detail-rich experience that keeps you locked in for hours.

The Spurs are the second team this century to start a playoff game on a 15-0 run or better and lose 😬 They join the 2017 Wizards, who blew a 16-0 lead in the East semis at Boston.