Kiran Biddinger (@kiranbiddinger) - Twitter Profili

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Kiran Biddinger@kiranbiddinger·26 Mar

It is always important to use new tools to reevaluate old questions. Here, we utilize advances in genetic epidemiology to find that alcohol consumption of any amount is associated with increased risk of cardiovascular disease.

Krishna Aragam@KrishnaAragam

In @JAMANetworkOpen, our work led by @KiranBiddinger uses observational and genetic epidemiology in large biobanks to re-examine an age-old question: What is the association of alcohol intake and cardiovascular disease? jamanetwork.com/journals/jaman…

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Krishna Aragam@KrishnaAragam·31 Eki

Today in @NatureGenetics, we report the discovery of a common CD36 variant specific to individuals of African ancestry that increases risk of DCM, and may help explain the ~2x higher rate of DCM/heart failure in this population nature.com/articles/s4158…

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Kiran Biddinger@kiranbiddinger·3 Eki

So grateful to work with this amazing team @DimitriMaamari @JurgensSean @KrishnaAragam

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Kiran Biddinger@kiranbiddinger·3 Eki

Excited to see our study out now in @JAMACardio! ⬇️ Genetic risk of dilated cardiomyopathy (both rare variant carrier status and a common variant-derived polygenic score) strongly associates with several secondary cardiomyopathies

Krishna Aragam@KrishnaAragam

Our study now out in @JAMACardio on the shared genetics of cardiomyopathies triggered by pregnancy (PPCM), alcohol (ACM), and cancer chemotherapy (CCM). Work across 4 biobanks - Mass General Brigham, FinnGen, UK Biobank, and Million Veteran Program ja.ma/4pMpEIE

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Kiran Biddinger@kiranbiddinger·3 Eki

@KrishnaAragam @CleClinicHVTI Congratulations! So happy for you!

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Krishna Aragam@KrishnaAragam·2 Eki

Honored to begin this week at @CleClinicHVTI leading new initiatives in CV genomics as: • Section Head, Haslam-Bailey Family Section of CV Genomics & Precision Medicine • Director, Center for CV Genomics & Data Sciences • William E. Macaulay Endowed Chair

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Sumeet Khetarpal@SumeetKhetarpal·24 Eyl

Happy to share our manuscript published today on regulation of cardiac adaptation to exercise training by PGC-1α and GDF15 in @NatureCVR! nature.com/articles/s4416…

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Krishna Aragam@KrishnaAragam·28 Şub

Now on medRxiv, we explore the genetic similarity between dilated cardiomyopathy (DCM) and peripartum, alcohol-induced, and cancer therapy-related cardiomyopathies (PPCM, ALCM, CCM). Led by star trio @DimitriMaamari, @kiranbiddinger, and @JurgensSean. medrxiv.org/content/10.110…

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Kiran Biddinger@kiranbiddinger·21 Mar

@shaan_khurshid @SudhaBiddinger Grateful to be part of such an incredible team! Congratulations @shaan_khurshid !

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Shaan Khurshid@shaan_khurshid·21 Mar

@SudhaBiddinger Thanks, Sudha! Grateful to have rising star @kiranbiddinger on the team.

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Sudha Biddinger@SudhaBiddinger·21 Mar

It isn’t about NAFLD, but it’s a heartfelt genetic association. Congratulations to @shaan_khurshid and colleagues!

Shaan Khurshid@shaan_khurshid

New in @NatureComms ! Our GWAS of #CMR based LV mass quantified using #AI segmentation (@broad_ml4h) in >50k @uk_biobank participants. 12 loci for indexed LVM, inc genes implicated in cardiomyopathy, contractility, and neurohormonal regulation. Paper: go.nature.com/3yUSmOl

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Shaan Khurshid@shaan_khurshid·21 Mar

New in @NatureComms ! Our GWAS of #CMR based LV mass quantified using #AI segmentation (@broad_ml4h) in >50k @uk_biobank participants. 12 loci for indexed LVM, inc genes implicated in cardiomyopathy, contractility, and neurohormonal regulation. Paper: go.nature.com/3yUSmOl

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Krishna Aragam@KrishnaAragam·14 Oca

Nice to see in @nytimes this nuanced discussion of the effects of alcohol intake on health, which cites our recent work led by @kiranbiddinger nytimes.com/2023/01/13/wel…

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Michael Levin@MGLevin·15 Kas

Excited to finally share the results of our GWAS and multi-trait analyses characterizing the 🧬 genetic architecture of 🫀heart failure, now published in @NatureComms Thanks to @damrauer and @bvoight28 for their mentorship, and all the contributors! nature.com/articles/s4146…

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Kiran Biddinger@kiranbiddinger·19 May

Special thanks to @JurgensSean , @patrick_ellinor , and @KrishnaAragam , as well as the rest of the phenomenal team @broadinstitute @mghcvrc that made this work possible.

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Kiran Biddinger@kiranbiddinger·19 May

Here, we show the importance of both rare AND common genetic variation to hypertrophic cardiomyopathy, especially for disease prediction and prevention.

Krishna Aragam@KrishnaAragam

3 weeks after FDA approval of mavacamtem for treatment of hypertrophic cardiomyopathy (HCM) our work in @JAMACardio led by @KiranBiddinger and @SeanJurgens examines relative and combined contributions of *rare* and *common* genetic variants to HCM risk …network-com.ezp-prod1.hul.harvard.edu/journals/jamac…

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Sudha Biddinger@SudhaBiddinger·15 Nis

TFE3 as a mediator of MTORC1 on SREBP and de novo lipogenesis. Congrats to @AranyLab- so great working with you guys!

The Arany lab@AranyLab

@BridgetGosis A massive story -- immensely proud. Major therapeutic implications for NAFLD/NASH. Wonderful collaboration with @SudhaBiddinger @PaulTitchenell @cholsoon_jang many others.

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Kiran Biddinger@kiranbiddinger·7 Nis

Our new study out now ⬇️ Genetic evidence links obesity to heart failure Many thanks to our coauthors @jpirruccello @shaan_khurshid @pnatarajanmd @JenHoCardiology @steven_lubitz @patrick_ellinor and as always my incredible mentor @KrishnaAragam

Krishna Aragam@KrishnaAragam

In @JAHA_AHA, more of our work led by @KiranBiddinger (1st year @Princeton undergrad), now using Mendelian randomization to probe potential causal links between a modifiable risk factor (BMI) and heart failure/cardiomyopathy ahajournals.org/doi/10.1161/JA…

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Sudha Biddinger@SudhaBiddinger·1 Nis

Just out! Our work showing insulin suppresses CVD risk in type 1 diabetes by modulating bile acids and lowering cholesterol absorption. Thread below. (1/6)

Circulation@CircAHA

#ICYMI: Insulin regulates cholesterol metabolism via FOXO1 @BostonChildrens #AHAJournals

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Kiran Biddinger@kiranbiddinger·30 Mar

So grateful for the kind words, but more importantly for the incredible mentorship and for the opportunity to work with such an accomplished and inspiring team of scientists.

Pradeep Natarajan@pnatarajanmd

For those who don’t know, 1st author of this paper covered by @ginakolata @nytimes 👇 is @kiranbiddinger who just graduated from HIGH SCHOOL. jamanetwork.com/journals/jaman… This prodigy is a product of Nature (@SudhaBiddinger) and Nurture (@KrishnaAragam) @Princeton @Milton_Academy

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Amit V. Khera@amitvkhera·29 Mar

Most popular medical advice ever: “A glass of wine per day is ‘good for your heart’!” But is it true? Sadly no… Great writeup of buzz-killing work from @kiranbiddinger and @KrishnaAragam using sophisticated genetic methods to tackle this question nytimes.com/2022/03/29/hea…

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Sek Kathiresan MD@skathire·29 Mar

Is a glass of🍷a day good for cardiovascular health? Answer very likely is a "No" Sorry. Distinguishing cause from mere correlation using human genetics @KrishnaAragam @kiranbiddinger @amitvkhera @ginakolata @NYTHealth nytimes.com/2022/03/29/hea…

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Kiran Biddinger@kiranbiddinger·26 Mar

Huge thank you to our coauthors for all the help and support, and an extra special thanks to @KrishnaAragam for the mentorship that made this all possible. @connoremdin, @maryehaas, @wallacemwang, George Hindy, @patrick_ellinor, @skathire, @amitvkhera

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Kiran Biddinger@kiranbiddinger·26 Mar

It is always important to use new tools to reevaluate old questions. Here, we utilize advances in genetic epidemiology to find that alcohol consumption of any amount is associated with increased risk of cardiovascular disease.

Krishna Aragam@KrishnaAragam

In @JAMANetworkOpen, our work led by @KiranBiddinger uses observational and genetic epidemiology in large biobanks to re-examine an age-old question: What is the association of alcohol intake and cardiovascular disease? jamanetwork.com/journals/jaman…

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