Kit Carson

@TgMacro @JesseBWatters

On @JesseBWatters right now. This is fucking COMEDY while the Epstein files are redacted.

@mike98572986 @anish_koka @plainyogurt21 It's over

$qure $clpt Must watch interview between @anish_koka and @plainyogurt21 on YouTube, one of the funniest things I have seen regarding Amt 130. Anish made so many dumb comments that I don’t think he will ever be able to speak on Amt 130 again. He was highly annoyed during the interview, check the facial expressions during the interview. If you are going to come after the HD community, you better come prepared. He was the opposite of prepared. I don’t like being a dick but if you’re going to mess with the HD community without proper knowledge you leave me no choice. 3 part thread Anish doesn’t even know how to spell the company’s name; he thinks they are called “Unicure.” He truly thought the original sham control was just a nick in the scalp. “Did they use burr holes?” he asks. He thought they didn’t do burr holes in the sham procedure. I guess this is why this guy believes Prasad’s 30 minute “nick in the head” sham control is the way to go. Anish doesn’t even know the basics of the original sham control trial. This is what happened in the original sham control: The original AMT 130 sham control involved actual burr holes; it was not merely a skin nick. Patients underwent the full cranial prep and burr hole drilling but did not receive the infusion. This was important for blinding, as a superficial nick alone would have been distinguishable from the real procedure by patients and caregivers. I’m very surprised Anish even put this out, It makes him look like a complete idiot. I highly recommend watching the YouTube video because you can see Anish getting extremely annoyed when Adu continues to push back on him. It was hilarious. If you watch this, you will quickly realize that Anish focuses almost entirely on the one year data. That is pretty much all he knows about the topic. “I mean, again, I don't follow this stuff. I'm buried in cardiology stuff. It's hard enough to track that.” Anish seems very annoyed that a “signal” can be used for accelerated approval. He says the HD community wants this because they are desperate, and he believes they will do anything regardless of the data. “Again, I don’t follow this space.” He says the HD community is a vulnerable population and that they might not be the most objective. Basically, Anish is saying he needs to protect the HD community from themselves. They just aren’t smart enough to look at the data themselves and make up their own minds because they aren’t objective. He doesn’t believe in accelerated approval because he feels that if a drug goes through AA, even if bad things happen, regulators will not be able to pull it. “Society has to pay for these drugs.”
“What is the best use of those resources for the nation?” This statement sounds pretty familiar; it sounds like the AV motto here. He says accelerated approval is for things that don’t have 12 red flags. With uniQure, he sees a bunch of red flags that suggest potential harm for patients. Adu pushes back and asks him what the harm to patients would be. Anish says the 12 hour surgery. Adu disagrees and says the surgery is relatively safe compared to the disease. Adu uses an ALS example that was pulled off the market, showing that the accelerated approval pathway can work if the company is held accountable. “Do you believe that going out to three years shows any signal at all?” Adu Anish says he has no idea. He basically admits that, as somebody who doesn’t know anything or follow the space, he caught himself and stopped his train of thought before saying it directly. He goes back to the one year data again. He says we need another surrogate. Anish doesn’t even know the history of NFL according to this interview. Adu smartly pushes back and talks about how, even though it is only 12 patients, the external control is well matched and compared against a much larger cohort. Thread 1/3 @biggercapital @DesertDweller93 @peter_mantas @MartinShkreli @houmanhemmati youtu.be/MNSyAHaGvpY

I ain't reading all that. I'm happy for you though, or sorry that happened."

@R3PPY_v2 @tombelaviv_ Contempt for the audience, even? Perchance?

Contempt. That's all I have

@nocontextscats Looks like that kitty is... In-bread

😴

@DesertDweller93 It's just a personality cult of fox news boomers, they'll all be dead or in nursing homes within the next 10 years then the world can heal. If we're lucky with how the midterms go we might even get to see kidfucker in chief impeached and convicted before he finishes his term.

So scary to me that about a third of the country ignores all the crooked stuff he does. Standard refrain is, well Biden or Hillary did it so it makes his corruption ok. Sadly I voted for the schmuck. The republicans need to grow spines and stop him.

We are ready to collaborate. We are ready to partner. We are ready to bring meaningful treatments to the HD Community. @Help4HDI @HDSA @HDYOFeed @laurencurehd @POTUS @FDA_KyleD @FDACBER @FDA @RobertKennedyJr @HHSGov

@ByzGeneral A day early no less

lol, lmao even.

Someone backing up the truck on $30 calls $qure

@Christina4HD @HASurfer297 Is that Makary's alt? Literally saying the same kind of tard shit he did on CNBC back in late February.

“We don’t approve drugs that require invasive brain surgery” — @HASurfer297 This raises an important question: who is “we” in this context?

Oh we are doing the “End of Civilization” thingy again 🥹

These are the types of women 55+ year old “girl dads” raise then try to shame men into marrying.

Clavicular got COMPLETELY turned off after a girl casually admitted she needs time to “reset her body” because of all the insane stuff she’s been involved in with different men the past few weeks 😭💀 The moment she said she’s trying to “restore herself” before dealing with anyone new, Clavicular instantly froze and asked: “What do you even mean by resetting your body?”

@mike98572986 rip bozo

$qure $clpt Boom

@DesertDweller93 @mike98572986 @anish_koka @DrMakaryFDA @uniQure_NV He did it for the izzat. And unfortunately (for him) he came up snake eyes. I'm not sure he will let this go, because technically he can't. Admitting he is wrong would be disastrous for him. x.com/i/status/19923…

My guess is now that his buddy @DrMakaryFDA is gone, @anish_koka will slither back under the rock he came from. He doesn’t answer direct questions and only spouts the Makary BS. @uniQure_NV $QURE AMT130 will get approval under AA and he will not appear under this thread again because he is such a loser and knows full well he lied in almost every tweet about AMT130. He is a miserable human being.

$qure $clpt I get some DM’s asking why even bother calling out @anish_koka , I call him out because the dude should have more empathy, especially as a doctor and a parent of a rare disease child. He is also clearly speaking about a topic that he knows very little about. He is not a neurosurgeon nor neurologist. Here is his 3 quotes, he presents it as a super scary thing, I can agree that it isn’t nothing but his facts are off. “But the FDA's role is to present a non-distorted benefit and risk analysis, and to ensure no entity can exploit desperate, vulnerable patients. In a space where investors have every incentive to amplify data that makes a treatment look safe, the FDA has to demand rigor.” “You don’t know what the true non Brain or Brain adverse complication rate is when you have a trial of 20 ppl. Ok to have a small n, but HD patients should understand you will not catch clinically meaningful adverse events with trial sizes like this.” “A system without that safeguard would not yield better cures; it would result in patients seriously harmed by therapies that had no hope of working.” The 0 deaths seen so far in roughly 50 treated patients is consistent with historical numbers with the delivery method. At 1,000 procedures with this estimate, you’d expect perhaps 2–5 deaths from surgical complications, predominantly from ICH, pulmonary embolism, or aspiration under anesthesia and not from the gene therapy itself. This is actually a favorable risk-benefit calculation for a fatal neurodegenerative disease. DBS is routinely offered to Parkinson’s patients at similar or higher surgical risk with no disease-modifying effect. 400–600 patients have received direct intraparenchymal brain gene therapy worldwide over the last 25 years, and the surgical mortality rate appears to be approximately 0% from the procedure itself. Deaths that have occurred in gene therapy CNS trials have come from vector related immune events, primarily in ICV and IV delivery at very high doses, a different risk profile than what AMT-130’s delivery uses.​​​​​​​​​​​​​​​​ Say hypothetically, which would be a high estimate, 10 hd patients die out of 1000 procedures, I’m pretty confident HD patients will take those odds all day everyday compared to the consequences of having nothing. Current risk profiles Multiple studies with different results( so these are estimates) but say 0.5 to 1 percent mortality rate for dbs- 12k procedures worldwide per year Litt 1-2 percent mortality rate with 10k worldwide procedures per year. HD patients have a 15 year life expectancy from symptoms, these are also not 15 good years, you need full time care to stay alive after a certain point. Why do you think HD patients have rates up to 10–12 times higher than the general population in suicide, it’s because this disease is absolutely brutal on so many different levels. Average life expectancy of someone with HD is 55 years old. This risk-benefit profile is superior to many "standard" medical interventions. For example, cardiac bypass surgery (CABG) carries a 2% to 3% mortality rate and a 10% to 30% complication rate, yet it is performed hundreds of thousands of times annually because it prevents the greater risk of fatal heart attack. Should we never do DBS or Litt? According to your thought process those would also be too risky since it’s highly likely intraparenchymal delivery has lower or comparable mortality rate as DBS. Anish and others just think we are here for the money, as @StockDaddy6597 once said, “I get it. I’ll be the first to admit that I will make a financial gain if it gets approved, and that will make me feel good. Anyone who tells you differently is lying.” “That also doesn’t preclude me from also wanting the best for the patients too, and being genuinely happy that hopefully their nightmares come to an end soon.” Thread 1/2

@ByzGeneral ZOGmerica getting ZOGed

Not ideal.

Re-imagining Villains 152

@HASurfer297 @Christina4HD @rachelreising96 Me reading this post

@Christina4HD @rachelreising96 I understand you are hopeful and HD sucks. I wish you the best of luck, but there is evidence of harm and lack of activity. The appropriate mechanism is an EAP for desperate patients while trials continue. Need more patients to better understand if the drug works or causes harm.

theblaze.com/columns/opinio… Read my second article here💙

@DanielLDavis1 @HealthRanger Higher.

Another 'accident' Mike??? @HealthRanger

@DanielLDavis1 Orange pedo retard gonna FAFO

Sr. Iranian negotiator Ghalibaf does not sound like someone who believes he has "no cards," as President Trump claims. To the contrary, he sounds confident Iran can sustain a new round of US attacks, should the president foolishly go down that path. More alarming, however, he seems confident they can mete out more pain than they can receive. We should not test Iran to find out. President Trump today met with his war cabinet to discuss the status of the conflict and to determine which course to choose next. As I see it, there are now only two primary options: 1) the 'walk away' theory whereby President Trump merely claims success - citing a battle damage assessment of things blown up in Iran during the first 40 days - and then warns that "we can come back again in the future" if various lines are crossed, and then withdraw our air, land, and sea forces. 2) return to major combat operations. This could be a 'pressure' campaign (as is apparently under consideration in Washington) designed to "coerce" Iran into accepting a better nuclear deal, or an all-out return to a blistering air and missile campaign, augmented with seizing strategically important islands in the Straits, designed to defeat Iran militarily. Option #1 will be expensive and embarrassing for the U.S., but it is also the only rational option now to limit the damage already done to the U.S., Israel, and our regional allies (not to mention to our economy via lost oil production on the global market). We will be seen by most of the world as having lost, but we will limit the damage to what's already been done and won't be harmed further, preserving the remainder of our missile inventories. Option #2 will fail to defeat Iran, but will come at great additional costs, both to our military and our allies in the region. The worst cost, however, will be to GCC countries' energy infrastructure, bc Iran will likely make good on its threat to target regional American allies and their economic targets. The impact on the global energy system - on top of the damage already done - could drive us all into a depression. Plainly stated, there is *no* military solution to forcing Iran into surrender, owing to the difficulty of geography, Iranian military missile capacity, its ability to control Straits traffic, and its culture and religion. Just having a lot of bombs and missiles and planes and ships can't defeat a landmass the size of most of Western Europe, especially if we don't even have a land force in the calculations. There is only one option that is rational and logical and would be in America's interests at this point; the 'walk away' option. I fear, however, President Trump will choose Option #2 anyway...