🎉 As the year winds down, we are filled with gratitude for an inspiring year of science, collaboration, and discovery. Wishing you all a joyful festive season and a bright, groundbreaking 2025 ahead! 🧬🔬🌟
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The Knoblich Lab
376 posts
The Knoblich Lab
@Knoblich_lab
Research group @IMBA_Vienna and the @viennabiocenter.
Vienna, Austria Katılım Mart 2019
48 Takip Edilen3.9K Takipçiler
The Knoblich Lab retweetledi
Increased stress through #DNAbreaks with simultaneous inhibition of #DNArepair in the #tumourcell. ️A team from #MedUniVienna and #UniversityHospitalVienna identified a new therapeutic approach for diffuse hemispheric #glioma. ➡ bit.ly/49iFC5q
@gojojohannes @NeuroOnc
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The Knoblich Lab retweetledi
A new preprint from the @Knoblich_lab and colleagues from @MaxPerutzLabs and @CeMM_News characterizes how different protocols and starting cell lines affect the variety of cell types in brain organoids. The team also proposes improved protocols for producing brain organoids.
The Knoblich Lab@Knoblich_lab
Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher_esk) and colleagues across Vienna. @MaxPerutzLabs, @IMBA_Vienna, @CeMM_News.
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All data is easily accessible in our Vienna brain organoid data explorer. You can look for your favorite gene or search for entire biological processes based on GO Terms. Check it out: …nna-brain-organoid-explorer.vbc.ac.at
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We also provide RNA-seq data for cell lines in all protocols across organoid development. We quantify sources of variability (1. organoid developmental stage, 2. protocol, 3. cell line) and provide early signatures consistent with protocol-driven organoid derivation.
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Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher_esk) and colleagues across Vienna. @MaxPerutzLabs, @IMBA_Vienna, @CeMM_News.
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The Knoblich Lab retweetledi
Save the date for the Athens International Symposium on 3-4 April 2025! Join scientists as they share their latest research on neural stem cells. Registration & abstract submission will open in October 👉 bit.ly/4diDKtK
@VanderhaeghenP2 @studerl @BrunetLab @Knoblich_lab
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The Knoblich Lab retweetledi
New paper alert! The @Knoblich_Lab partnered with researchers at the @humantechnopole and @unimib to develop new brain organoids with distinct cortical areas and front-to-back patterning and study human-specific brain development and disorders. Read more: bit.ly/3ZK5wMX
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The Knoblich Lab retweetledi
Excited to share this work now published @naturemethods and to have contributed to develop this interesting model of cortical patterning. A fantastic collaborative work with another @Knoblich_Lab alumnus @BosoneCamilla , @castaldi_davide @CarloEmanueleV1 @humantechnopole
IMBA imbavienna.bsky.social@IMBA_Vienna
New paper alert! The @Knoblich_Lab partnered with researchers at the @humantechnopole and @unimib to develop new brain organoids with distinct cortical areas and front-to-back patterning and study human-specific brain development and disorders. Read more: bit.ly/3ZK5wMX
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The Knoblich Lab retweetledi
I am beyond happy to share that our polarized cortical assembloid (polCA) paper is out today in Nature Methods! nature.com/articles/s4159…
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The Knoblich Lab retweetledi
The @Knoblich_lab has developed polarized cortical assembloids with the help of a localized FGF8 source. This technology allows mimicking patterning events during brain development.
@krenn_veronica @BosoneCamilla @castaldi_davide @gtesta72
nature.com/articles/s4159…
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The Knoblich Lab retweetledi
Chong Li, postdoc at the #Knoblich_Lab, will soon leave IMBA to take a new position as group leader at the Chinese Institute for Brain Research (@chinese_brain). Learn more about Chong’s journey at IMBA and his future position here: bit.ly/ChongLiExit
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The Knoblich Lab retweetledi
Extremely grateful for the support of the @Knoblich_lab and @IMBA_Vienna during this postdoc journey, where I met amazing scientists from around the world! Excited to start my own group soon at CIBR to continue exploring some of the most fascinating areas of human brain research!
IMBA imbavienna.bsky.social@IMBA_Vienna
Chong Li, postdoc at the #Knoblich_Lab, will soon leave IMBA to take a new position as group leader at the Chinese Institute for Brain Research (@chinese_brain). Learn more about Chong’s journey at IMBA and his future position here: bit.ly/ChongLiExit
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The Knoblich Lab retweetledi
Wohoo! Great work, @FahrenbergerM , on improving scRNA-seq analyses. Easy to use, implementation in Seurat workflow, better results across the board! Happy to have pitched in. Congratulations!
Martin Fahrenberger@FahrenbergerM
I m happy to present our latest preprint, and the main work of my PhD-project: "GTestimate: Improving relative gene expression estimation in scRNA-seq using the Good-Turing estimator" In this manuscript we introduce a new normalization method for scRNA-seq data.
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The Knoblich Lab retweetledi
I m happy to present our latest preprint, and the main work of my PhD-project:
"GTestimate: Improving relative gene expression estimation in scRNA-seq using the Good-Turing estimator"
In this manuscript we introduce a new normalization method for scRNA-seq data.
bioRxiv Bioinfo@biorxiv_bioinfo
GTestimate: Improving relative gene expression estimation in scRNA-seq using the Good-Turing estimator biorxiv.org/cgi/content/sh… #biorxiv_bioinfo
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The Knoblich Lab retweetledi
We're at the cover of Cell Stem Cell.
We're at the cover of Cell Stem Cell.
We're a-
(I can barely believe it. 🤯)
We found out why some people are born without the main interhemispheric bridge. 🧠
👏 to @PhDexheimer for this beautiful illustration of the corpus callosum.
Cell Stem Cell@CellStemCell
The June issue of CSC is live! The cover story😍😍😍 presents an organoid model of the corpus callosum, shown here as a bridge btwn metaphorical brain hemispheres/city skylines, which @Knoblich_lab used to study white matter defects from Arid1b haploinsufficiency. Read this and more! cell.com/cell-stem-cell…
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