
Davide Castaldi
107 posts

Davide Castaldi
@castaldi_davide
PhD Student in Computational Biology. Geek. Biker.






Our February issue is live! 🎉 nature.com/nmeth/volumes/… On the cover, a human brain emerges from multiple stem cell lineages, representing a method to link genetic variation to neurodevelopmental trajectories. Paper here: nature.com/articles/s4159… Image by Philipp Dexheimer.


📢 Paper alert! Our paper on cortical brain organoids multiplexing is out @naturemethods. nature.com/articles/s4159… Together with the Research Briefing nature.com/articles/s4159… /1

The team of @gtesta72 have developed methods for multiplexing cortical organoid development to trace neurodevelopmental trajectories at high resolution and at scales. They report SCanSNP, an algorithm to deconvolve cell identities. nature.com/articles/s4159…



New paper alert! The @Knoblich_Lab partnered with researchers at the @humantechnopole and @unimib to develop new brain organoids with distinct cortical areas and front-to-back patterning and study human-specific brain development and disorders. Read more: bit.ly/3ZK5wMX


Honoured to take part in this fantastic collaborative effort from @gtesta72, @Knoblich_lab, and @krenn_veronica labs, aiming to expand modelling opportunities for human brain through polarized cortical assembloids (polCAs). Check it out on @naturemethods nature.com/articles/s4159…





New paper alert! The @Knoblich_Lab partnered with researchers at the @humantechnopole and @unimib to develop new brain organoids with distinct cortical areas and front-to-back patterning and study human-specific brain development and disorders. Read more: bit.ly/3ZK5wMX






📢📢📢How can we obtain a robust outer radial glia (oRG) population in 🧠organoids from guided differentiation? Exogenous LIF does the trick. Our new paper shows that cortical pericytes are among the cell types secreting LIF. Adding pericytes to cortical organoids recapitulates oRG emergence, highlighting the importance of the microenvironment in shaping the diversity and differentiation of neural progenitor cells.

