Krishnamoorthi Srinivasan

Check out our new publication revealing how mycobacterial EF-G2 stands apart than its other counterparts!! Cryo‐EM structural analyses reveal a unique role for elongation factor G2 (EF‐G2) in Mycobacteria - Baid - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1111/fe…

@AlbertW_Lab @IGBMC @Inserm @CNRS @unistra @ERC_Research @IMC_Bio @instructhub Beautiful work! Such an elegant system. This answers one of the most fundamental questions on translation initiation. Congratulations to all the authors!

We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/sc… The work was supported by @IGBMC, @Inserm, @CNRS, @unistra, @ERC_research, @IMC_Bio, and @instructhub. 1/7

I hope the author of Today's Wordle puzzle has a terrible day.

@debashmitasark5 @CMLSjournal @DuttShilpee @CRI_ACTREC @amartya_acad @SHAINAMANDI Congrats!! 😄

Elated to share this manuscript resulting from my Ph.D. thesis published @CMLSjournal. Grateful to my guide @DuttShilpee for her immense support and guidance, my research institute @CRI_ACTREC and co-authors @amartya_acad @shainamandi for their help. doi.org/10.1007/s00018…

Massive complex, in magnanimous details! Congrats to all the authors involved!

What a cool discovery!

bioRxiv: Cytoplasmic ribosomes hitchhike on mitochondria to dendrites dlvr.it/TDBq1d

🚨New #Publication Alert! The National Electron Cryo Microscopy facility at the Bangalore Life Sciences Cluster @BLiSC_India has supported a new study by researchers from @csir_iicb and @AcSIR_India! The team decoded the exact mechanism by which mycobacteria resist macrolide #antibiotics. They found how the protein HflX plays an important role in this resistance, and targeting this mechanism could make #mycobacteria more vulnerable to existing antibiotics! The team studied how HflX & a nucleotide (A2286) are affected by the antibiotic erythromycin in Mycobacterium smegmatis. They found that the conformation of A2286 is altered by erythromycin binding. HflX senses the presence of erythromycin via this conformation and binds more strongly to ribosomes, which likely acts as a first line of defence against the antibiotic. These findings help explain how HflX detects macrolides antibiotics and contributes to the bacteria's resistance. @Taslimarif @DBTIndia @NCBS_Bangalore @DBT_inStem @KrishS_023

@sushant16m8 @Structure_CP @csir_iicb Unlike the ones incharge of my fellowship, I have done my due diligence, that too in a timely manner😂

@KrishS_023 @Structure_CP @csir_iicb Many congratulations, Krishnamoorthi.... Nice work... Btw, Acknowledgement to SPM fellowship is missing😅...

Happy to share a big chunk of my PhD work, published now at @Structure_CP! Big thanks to my guide Dr. Jayati Sengupta, @csir_iicb and my co-author Aneek Banerjee!

@abandopa No we can't. The whole process is stalled now. Vendors say there is no clarity on the exemption, and when they are ordering the chemicals, the sigma site is still showing the enhanced 150% import duty.

Asking all colleagues who use imported laboratory chemicals. Are you able to order any chemical - solvents, buffers, nucleotides, antibodies, enzymes etc.? We are stuck as official price from Sigma and Thermo is with enhanced (150%) import duty.

What an experiment🤣🤣

@GbNaib 🤣

Kabi khushi kabi gham main huta hai 🤣🤣 Hamstring 🤣

@amuk3702 Many congratulations to the whole team! The world needs more such collaborative efforts!

Celebrating Excellence: Global MRC GCRF Network on Neglected Tropical Diseases Wins MRC Outstanding Team Impact Award 2023. As a fortunate member of this exceptional team, I am deeply proud of the work we have accomplished. #MRC_OUTSTANING_TEAM_IMPACT_AWARD_2023

CryoEM labs doing ribosomes!

@RupamPa96165633 @iiserkol @CopperBioGroup Congrats Dr. Rupam Paul! 😄

End of an exciting journey!! Thank you for the opportunity @iiserkol @CopperBioGroup

“A gift for the fans.” - THA7A FOREVER! 🦁💛 #Dencoming #WhistlePodu

Bacteria have an astonishing ability to put their life on pause in the face of stress and starvation by entering a state of dormancy. Here, we discover one aspect of this remarkable self-preservation strategy: nature.com/articles/s4158…

@AritraBej @MOZUMDERSukanya Congratulations!

Great work, Team! Great start to the new year @MOZUMDERSukanya! Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1 | Biochemistry pubs.acs.org/doi/10.1021/ac…

Estimating the biological age of 11 organs via blood testing + proteomics! Really cool study led by @JarodRutledge1 and @hammy_oh from @wysscoray lab, with exciting avenues for future use in the clinic & research