

Darko Barisic
375 posts

@LabBarisic
Assistant Professor of Cancer Biology @WeillCornell NIH K99/R00 Fellow @theNCI Chromatin & Epigenetics in Cancer.





Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!


🧬 💻 We're looking for a motivated postdoctoral associate in computational biology to join Barisic Lab at Weill Cornell Medicine and study chromatin remodeling and 3D genome organization. Please share and apply below: postdocs.weill.cornell.edu/opportunities/…





Excited to share our new paper in @NatureGenet led by the incredible @6jinLee! We uncover how cohesin loss impairs postmitotic refolding of 3D chromatin topology with limited context-specific effects on gene activation—especially during differentiation. nature.com/articles/s4158…






Welcoming Dr. John P. Leonard as chief of the Division of Hematology & Medical Oncology and director of the Center for Blood Cancers at @Perlmutter_CC! A global leader in lymphoma care, he brings decades of research and clinical expertise. Learn more: bit.ly/46eRupF





Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell. nature.com/articles/s4158…




My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…