LauraPasin

We've just presented and published a multicenter RCT at #CCR23 and in @JAMA_current! Continuous vs Intermittent Meropenem Administration in Critically Ill Patients with Sepsis: The #MERCYtrial! 🔗 jamanetwork.com/journals/jama/… This 🧵 will explain the study in detail /11 #FOAMcc

B1/3 NEW ANTIBIOTIC QUIZ Does the regimen of #meropenem administration (continuous vs intermittent) influence survival in ICU patients with #sepsis or #septicshock?   Stay tuned for #MERCYtrial @DrToddLee @nickmmark @iceman_ex @CritCareReviews @iamyourgasman @FOAMecmo #FOAMcc

@SRAnesthesiaICU @DrToddLee @nickmmark @iceman_ex @msiuba vote and retweet above how do you administer meropenem? @DrMCecconi @ProfMBassetti @MGrecoMD @fabiodoc64 @KatiaDonadello @Area_Critica_ @f_g_sanfilippo @ECMOdaily @KhannaAshishCCM @pwierusz @abd_jabbar @jiapenghuang @germ_red @ECMOprincess @FOAMecmo @DrECMO @MarcVives13

1-4 Our updated meta-analysis confirmed that low #tidalvolume during #onelungventilation 🔼 P/F ratio, 🔽 PPCs and 🔽 arrhythmias, but 🔼 PaCO2 & no effect on hospital stay sciencedirect.com/science/articl… @JCVAonline @SCVA1997 @scahq @EACTAIC @Laura_Pasin @giovannilandoni @gelysamara

In this meta-analysis by Covello, @Laura_Pasin, @giovannilandoni, and others in @NEJMEvidence, steroids were associated with increased mortality when administered to COVID-19 patients not requiring oxygen. #steroids #COVID19 buff.ly/3Vu4kZI

A nice @NEJMEvidence editorial on our article on mortality increase when using #glucorticoids in #covid19 who are not receiving #oxygen x.com/nejmevidence/s… “...under some circumstances, randomized controlled trials can become infeasible as evidence accrues (e.g., randomization to a probable harmful exposure), as in the meta-analysis by Covello et al.” kudos to the authors, especially those who are active on twitter :) @Laura_Pasin @SFresilli @LudhmilaHajjar @azangrillo @SRAnesthesiaICU #medtwitter #Foamed

“…our meta-analysis shows that administering glucocorticoids in hospitalized patients with Covid-19 not receiving oxygen is likely associated with worse clinical outcomes.” Full study: eviden.cc/3MnrDSA #IDTwitter #ARDS #CriticalCare

#CritCare #OpenAccess #Propofol may reduce survival in perioperative and critically ill patients. Read the full article: rdcu.be/c9UU8 @jlvincen @ISICEM #FOAMed #FOAMcc

Our latest manouscript sheds new light on treating hospitalized #COVID19 patients not on oxygen therapy! According to our study sistemic glucocordicoids are detrimental in this setting. 🚨 Read our findings in NEJM Evidence and help spread the word! 📢 #research #coronavirus🦠

Meta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen | NEJM Evidence evidence.nejm.org/doi/full/10.10…

‼️Going deep into the problem ⚠️Is propofol detrimental for survival❓ Comments and reflection on propofol and survival MA with the authors: Me and @YukiKotani5 👉ccforum.biomedcentral.com/articles/10.11… @ITACTAtwits meet the authors TODAY 6.00pm 🔗FREE link itacta.org #FOAMcc

🚫 DON’T use glucocorticoids in oxygen-free #COVID19 pts Just published @NEJMEvidence   Guidelines are against glucocorticoids in pts not on O2 but effect on survival remains unclear   Our meta-analysis found that glucocorticoids increase mortality 🔗eviden.cc/3MnrDSA 1/5

Propofol may increase mortality in ICU and perioperative settings🚨 Our new meta-analysis documented statistically significantly higher mortality in the #propofol group than control group Let's go into depth about this provocative result 🧵/7 🔗ccforum.biomedcentral.com/articles/10.11… #FOAMcc

Top Italian #women working in #ICU #Anesthesia by followers. Who did we forget? @AnesteTista @LaCampo4 @mary_el83 @Luna41346966 @chiara_robba @dr_bearighetti @SilviaDeRosa11 @ElenaG_Bignami @MariaVargas1st @KatiaDonadello @sofia_rosaria @BaiardoMartina @mgcalabroMD @DormioSara

YES! it was 2013 when we @Laura_Pasin @azangrillo published a letter in the @NEJM suggesting that #Glutamine supplementation is detrimental for survival of critically ill patients according to multicenter #RCT pubmed.ncbi.nlm.nih.gov/23902499/

This article had large media coverage in Italy, was poorly interpreted, and has 1 dangerous message YES non-steroideal antinflammatory agents are ok for patients at home (minor benefits) NO! corticosteroids are dangerous and should not be prescribed at home (increase mortality)

LET’S REDUCE TRANSUSION BY 20% WITH #TRANEXAMIC acid #TXA 1/ We helped @PHRIresearch in conducting the #POISE3 #RCT published in the @NEJM and presented #ACC22 also #mortality is reduced by 10% in this @NEJM #RCT on #tranexamic acid. This is probably the most important finding

Proud to join @FrontiersIn Anesthesiology as Associate Editor. With an amazing editorial team, this new journal will help shape the future of anesthesiology. Find out more: frontiersin.org/journals/anest…

The circus has come to Padua! #StopWarInUkraine #PeaceInUkraine

🫀ANESTHETIC MYOCARDIAL PROTECTION resurrection? Dozens of colleagues and studies worldwide found a cardioprotective effect of volatile agents in laboratory, animal and human studies over the last decades. We re-analyzed our large #MYRIADTrial ➡️ jcvaonline.com/article/S1053-… #FOAMcc