ZEBRALille

Our work on 🦓🐟 at @Canther_Lille is funded by @univ_lille @CNRS_HdF @Inserm @CHU_Lille @canceropole_no @laliguecancer du Pas-de-Calais 🙂

@iman_560 You are wrong. Nothing starts with N and ends with G. 😜

@Matt_Pinner LOL. Nothing starts with N and ends with G. 🤪🤪🤪🤪

Is it true 🤔

@KarinaYaniv My thoughts are with you. Take care

Thank you, our dear friends, for the warm words and offer to help. Weizmann was hit by a missile last night- a real nightmare😭. Thank God no one is hurt, but there’s significant damage to many labs. I’m stuck abroad, waiting desperately to be able to go home to my family and lab

The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s4158… 1/n

Excited to share our latest study! Cyclic ruthenium-peptide prodrugs penetrate the blood-brain barrier and target #glioblastoma, activated by light in orthotopic #zebrafish tumor model. A promising step toward innovative therapies! #CancerResearch pubs.acs.org/doi/10.1021/ac…

The main study from my postdoc @MGodinhoFerr is out! #Telomerase isn't required for tumor initiation but its lack drives #Cancer #regression later. Regression occurs via tumor-autonomous mechanisms (cell cycle arrest, apoptosis, melanocyte differentiation) and immune rejection.

Excited to share @AmpatzisLab and @KizilLab's's new paper on #zebrafish 's intracardiac nervous system (IcNS), highlighting the presence of pacemaker-like neurons that partake in heart rhythm—linking cardiac and neuroscience research. nature.com/articles/s4146…

1/4 Our @biorxivpreprint, 'Origin of Ewing Sarcoma by Embryonic Reprogramming of Neural Crest to Mesoderm' is now available on bioRxiv! In this study, we explore the enigmatic origin of Ewing sarcoma using our zebrafish genetic cancer models. We revealed that neural crest cells can uniquely tolerate EWSR1::FLI1 expression, leading to tumor formation in vivo. A big thanks to our collaborators @clairearataphd and @CrumpLab for this adventurous journey! #NeuralCrest #cancer #EwingSarcoma #zebrafish @amatrudalab @ChildrensLA @biorxiv_cancer👉biorxiv.org/content/10.110…

Zebrafish study reveals clues to how inflammation drives scoliosis. elifesciences.org/articles/96831…

David Ish-Horowicz FRS (1948-2024): outstanding scientific discovery, with a unique touch of selfless humanity An Obituary by Ilan Davis (@ilandavis), with his personal reflections on David's unique approach to science and scientific friendship: journals.biologists.com/dev/article/15…

A zebrafish knockout model of the N-terminal acetyltransferase Naa80 demonstrates that this enzyme is required for actin N-terminal acetylation and normal inner ear development. @medofak_uib @OMRF @NAT_machinery @varshneylab @rasmusree hubs.la/Q02STX1j0

The dynamics & functional impact of tRNA repertoires during early zebrafish embryogenesis @ddnedialkova et al @MPI_Biochem find increased translational activity during maternal-to-zygotic transition sensitizes maternal mRNA decoding rates to tRNA supply embopress.org/doi/full/10.10…

@ritafior @ChampalimaudF @TheSFPM Wow. That’s so great. Congratulations to the team!

🚨NEW study from our LAB showing the predictive value of Patient-derived Breast Cancer 🐟zebrafish Avatars ! A co-clinical study where we compare the patient clinical response to treatment with their matching 🐟zAvatar! ✨100% @ChampalimaudF @TheSFPM biorxiv.org/content/10.110…

Gα13 controls pharyngeal endoderm convergence by regulating E-cadherin expression and RhoA activation Read this #OpenAccess Research Article by Bo Hu, @FangIowa & colleagues: journals.biologists.com/dev/article/15…

SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and #vascular function. #epigenetics -> embopress.org/doi/full/10.10…

📢New Preprint alert!🚨 Excited to share my PhD work! SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. biorxiv.org/content/10.110… from @sridharsivasubb @vinodscaria lab @IGIBSocial #lncRNA #vascular #zebrafish #coagulation

Great collaboration with Dr. Duong and Dr. Murphy. Also, thanks to Anjelica Rodriguez-Parks for her effort in establishing CUT&Tag in my lab and contributing to this research. …eneticsandchromatin.biomedcentral.com/articles/10.11…

Interesting review by @Lau_E_Sanchez: "Knockout, Knockdown, and the Schrödinger Paradox: Genetic Immunity to Phenotypic Recapitulation in Zebrafish" (mdpi.com/2073-4425/15/9…): Phenotypic discrepancies between zebrafish knockouts and knockdowns aren't as wide as once believed! Maternal gene contributions can mask zygotic mutations, creating unexpected outcomes in zebrafish phenotypes and introducing the concept of "Schrödinger genes"—where genes may exhibit conditional phenotypes! Morpholinos (MOs) still have a role in zebrafish research, but their off-target effects require strict controls. Pairing MOs with CRISPR tools offers a powerful combination for understanding gene function! Graded maternal contributions lead to phenotypic variability, complicating results in knockout models. Both maternal & zygotic inputs must be considered for accurate gene function studies! "Susceptible," "Immune," & "Schrödinger" genes—categorizing phenotypes based on maternal-zygotic interactions.

Embryo cells differ a lot from adult cells - but why? In a new paper from the @NorthTrista lab, they show that embryonic blood stem cells use mitophagy, which the adults do not. A great combo of #zebrafish and iPS cells (two systems I love) to show relevance from fish to humans.