Moritz von Scheidt

In version 25.1 of the Human Protein Atlas, a dataset based on Deep Visual Proteomics has been integrated in the Single Cell resource to provide mass-spectrometry based proteomics at an unprecedented resolution across cell types and tissues. proteinatlas.org/news/2026-05-2…

5/5 All data is integrated into @ProteinAtlas alongside matched RNA: proteinatlas.org/humanproteome/… Shout out to Mathias Uhlen, @CarolineWeiss30 & a wonderful Munich–Stockholm collaboration 🇩🇪🇸🇪

4/5 Cell type resolution exposes biology bulk profiling misses. We find cancer-testis antigens, proteins normally restricted to immune-privileged sites and actively targeted by immunotherapies, in oocytes of the female germline. Worth noting for CTA-directed therapy safety.

3/5 Matched RNA-protein comparison across 27 cell types reveals a clear rule: Concordance is organized by pathway, not by cell type. Metabolic pathways at the protein level and signaling pathways at the transcript level. A practical guide for when RNAseq predicts protein.

2/5 27 cell types × 14 tissues × ~14,000 proteins measured directly in tissue by Deep Visual Proteomics. The human proteome partitions into two regimes: A universal core that sustains cellular life, and tightly restricted programs that define cell type identity.

1/5 Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body. biorxiv.org/content/10.648…

Beautiful work by @CarolineWeiss30/ @labs_mann, Mathias Uhlen, @MoritzScheidt & team! A cell type-resolved proteomic atlas of the human body - integrated into the @ProteinAtlas.

Exploring the Biology of Human Coronary Atherosclerosis: Pathways to Prevention! ow.ly/6I3A50Z2qFj #EHJ #coronary #atherosclerosis #mechanism #cardiotwitter @ESC_journals @escardio

Version 25 of the Human Protein Atlas is launched. New additions are Olink HT and SomaScan data for 32 cohorts including diseases and childhood development, more single cell data with 4 new tissues and 23000 predicted structures for protein interactions proteinatlas.org/news/2025-11-1…

VESALIUS-CV: among high-risk pts *without* prior events, evolocumab (PCSK9 mAb) led 45mg/dl lower LDL-C & 25% RRR of a *first* major CV events. Secondary analyses indicated 20% reduction in all-cause mortality! nejm.org/doi/full/10.10… @NEJM #AHA25 My thoughts on “primary prevention.” Many will quibble that this isn’t primary prevention because most had CAC. But the prospect of treating patients with medicines who have never had an event & not necessarily making them feel better requires a demonstration of benefit for major outcomes. Pretty much all ASCVD trials focus on preventing recurrent events. Hats off to the investigators, @Amgen, trial participants to moving earlier in the disease course. Bold and important. Current guidelines stratify secondary prevention to very high risk ASCVD (those with major events and risk factors) as a group for the most potent LDL-C-lowering. However, these data suggest high risk primary prevention deserves similarly most potent LDL-C-lowering.

In a study in Science, a team of researchers have mapped how thousands of proteins in human blood shift as a result of aging and diseases. The molecular "fingerprints" from 59 diseases can enable blood tests to discern troubling signs from common. proteinatlas.org/news/2025-10-0…

In >8,600 CAD patients, CHIP was linked to higher mortality, visualized in plaque macrophages, and associated with plaque vulnerability. We uncovered a novel mechanism where TET2-CHIP drives lipid uptake & inflammation—making it a targetable source of residual risk. @DZHK_germany

🚨 Excited to share that our latest study on the role of inflammatory activation in endothelial cells during the infarct response is now published in Circulation Research! Huge thanks to all co-authors especially Lukas, Till, Simone, and Ariane for driving this project forward.

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…

Plaque erosion is a main mechanism for myocardial infarction: JAK2 V617F linked to erosion risk doi.org/10.1093/eurhea… #MI #CAD #cardiotwitter, @ESC_Journals, @escardio

Mosaic loss of Y chromosome portends a high risk of mortality after coronary angiography. Read more in #EHJ 👉 bit.ly/4aU5upd @RoccoMontone @ehj_ed

Prasugrel proves more effective than ticagrelor in clinical practice when emulating the randomized trial ISAR-REACT5 in claims. Hot off the press w/ @HannesKrefting @HendrikSager @MoritzScheidt

Our latest publication @JAMACardio: We identified 17 #AorticStenosis specific genetic loci, including 5 novel loci. Serum #phosphate is a unique AS risk factor. Our findings reveal AS's distinct pathways from #CAD, paving the way for targeted therapies. ➡️bit.ly/4ezb2pq

1/ 🧵Introducing UNICORN,🦄 the first #AI model for integrating multi-stain #histopathology images for classification, designed to tackle missing data during both training and inference. Great colab between @HelmholtzMunich & @TU_Muenchen German Heart Centre! the architecture ⬇️