Living Forever

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Living Forever

Living Forever

@LivingForever8

What is the meaning of life? To survive; just consider the alternative. There is nothing to be gained from death. It's well past time for it to end.

New York Katılım Haziran 2021
146 Takip Edilen434 Takipçiler
Living Forever
Living Forever@LivingForever8·
Now let's find something for sensorineural hearing loss. Many people wearing hearing aids that don't work very well. Let's heal them all!
Avi Roy@agingroy

42 patients. One injection each. 90% could hear again. The largest gene therapy trial for inherited deafness just published in Nature. Researchers delivered a working OTOF gene directly into the inner ear using an AAV vector. Average hearing went from 106 dB to 52 dB. Half the patients hit normal range. The youngest was under a year old. The oldest was 32, breaking the assumption this only works in developing ears. 2.5 years of follow-up. No retreatment. No dose-limiting toxicity. Cochlear implants route around the problem. This goes after the root cause.

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Regeneron
Regeneron@Regeneron·
Today the U.S. FDA approved our medicine – the first and only gene therapy for genetic #hearingloss – signaling a new era where enabling 24/7 natural hearing is now possible. We are proud to make this available for free in the U.S. Read more: bit.ly/4e6f2Rx
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Daniel Jeffries
Daniel Jeffries@Dan_Jeffries1·
More people will die from suppressing AI than from the imaginary AI apocalypse. They'll die from restricting safe self-driving cars that are 90% better drivers than people who kill 1.5 million people and injure 50 million more every year. They'll die from the vaccines and cures that never get created. They'll die from all the myriad of helpful inventions that never get created by geniuses in a datacenter. They'll die from preventable diseases that they could have asked their chat bots about so they were better informed when they went to see their doctors but who couldn't ask because short-sighted legislators made it so the chat bots had to refuse to answer. They'll die from the slower economy that stifles robot driven factories over wildly overblown jobs apocalypse fears which will mean we never get a vast array of new and more affordable goods. They'll die from the cheaper solar panels and batteries that would get made by those automated factories which would slow climate damage and provide cheap energy to undeserved areas. They'll die from the super smart tele-AI doctors that never get deployed to remote areas. And they'll die as fanatics from the stop AI movement radicalize their followers to shoot people or throw firebombs.
Max Tegmark@tegmark

Senator @BernieSanders has invited me and three other AI researchers to a public panel on AI existential risk & international cooperation at the U.S. Capitol 7pm Wednesday April 29th. RSVP here to join us for this important conversation: forms.office.com/Pages/Response…

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Michelle Lee
Michelle Lee@michellearning·
Welcome to the scientific revolution. 100s of robots. Zero coffee breaks. America’s largest autonomous lab, open today.
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Peter H. Diamandis, MD
Peter H. Diamandis, MD@PeterDiamandis·
We're so close to longevity escape velocity (LEV by 2033) that your sole responsibility right now is to avoid dying from something stupid. The next 5 years will deliver more medical breakthroughs than the previous 50.
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Dr Singularity
Dr Singularity@Dr_Singularity·
Nanobot based immune systems By the early-mid 2030s, nanobot based immune systems could start to feel like the first true upgrade to human biology, moving us from reactive medicine to continuous, real time optimization. Instead of waiting for illness, trillions of microscopic machines will be scanning, repairing, and protecting your body every second, catching problems at the cellular level before they ever become visible. We could see early systems clearing damaged cells, assisting the immune system, improving tissue repair, and dramatically accelerating recovery. Cancer, infections, and many chronic conditions might begin to look less like life threatening events and more like manageable, quickly neutralized anomalies. Aging itself could start to shift from something inevitable to something increasingly controllable. Not fully "solved" yet, but slowed, stabilized, and partially reversed in ways that would already feel extraordinary by today’s standards.
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SciTech Girl
SciTech Girl@scitechgirl·
🚨 ZOMBIE CELLS” IN YOUR BODY… AND A NATURAL WAY TO FIGHT THEM? What if aging isn’t just time—but damaged cells that refuse to die? These “zombie cells” build up in your body and slowly cause inflammation and damage. Scientists call them senescent cells. Now here’s the twist… A natural compound called fisetin (found in strawberries and apples) may help clear them out. Early studies show it can reduce these cells and support healthier aging. But there’s a catch—most research is still in early stages, and it’s not yet proven in humans. Still… the idea is powerful:
What if aging could be slowed by removing what shouldn’t be there? Source:
Yousefzadeh, M. J., et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine.
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David Sinclair
David Sinclair@davidasinclair·
In 2020, we discovered safe age reversal - cells never lost their identity. Importantly, in this study, OSK is pulsed to relax chromatin and reset gene expression programs without erasing cardiomyocyte identity, a requirement for use in the clinic.
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David Sinclair
David Sinclair@davidasinclair·
NEW STUDY: OSK rewinds the clock and pushes adult heart cells into a regenerative state that improves heart repair Why is this such a big deal? Because adult heart cells do not meaningfully divide, which is why the heart heals with scar tissue rather than regeneration. This fundamental limitation has defined cardiology for decades In 2020, OSK restored function in damaged neurons. Now the same principle is being explored in the heart, building on results already seen in eye, brain, liver, and skin Consistent with the Information Theory of Aging: cells retain the instructions for repair; aging is a loss of access to them. Restore that information, and regeneration follows…
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Houman David Hemmati, MD, PhD
Houman David Hemmati, MD, PhD@houmanhemmati·
😳 AMAZING scientific advance published today by @ScienceTM! A previously untreatable mutation in a patient with cystic fibrosis was corrected in patient-derived organoids in vitro with GENE EDITING! Huge news because it proves that challenging genetic diseases can potentially be fixed by correcting the mutation itself without inserting a whole new gene (gene therapy), something that carries risks & may be unfeasible (gene too long to insert). We are nearing a very different era when it comes to genetic diseases!
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Siim Land
Siim Land@siimland·
Supplement tierlist (part 2): - Magnesium threonate: 9/10 - NAC: 8/10 - Vitamin D3: 7/10 - Rhodiola rosea: 6/10 - HMB: 5/10 - Spermidine: 4/10 - Lycopene: 3/10 - Turkesterone: 2/10 - Pterostilbene: 1/10
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Living Forever
Living Forever@LivingForever8·
So well said! My feelings exactly!
Daniel Shur@teleodaniel

“You’re born, you grow up, you have a career, and then you get older and then you die. And that's just like the acceptable plan. Even if the plan is horrible… as long as we're going to plan, everybody goes along with it.” @realNathanCheng is one of the most prolific activists in the longevity field. He argues that aging, decline and death are not really a great plan, even if it's the way things work today. He has dedicated his life and career to finding us a new plan. Follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:35 Why did Nathan dedicate his life to defeating aging & death? (And the absurdity of asking that question) 8:59 Why has Daniel been on the fence, despite being longevity-pilled 14:09 The agency and bravery of founders to tackle the hardest problems (like aging) 18:46 Many ways to contribute to longevity besides entrepreneurship 19:41 Is longevity underinvested into? 24:48 What does it mean to treat aging itself as the issue (vs other diseases) 32:23 Do we need more scientific arguments, or philosophical arguments? 39:50 Nathan’s experience longevity-pilling influential people 47:03 Billionaire paradox 53:18 The challenge in going from viewing aging as inevitable to malleable 57:29 What needs to change about our culture to save us from aging & death 1:16:55 Should we be intolerant of pro-death & pro-aging views? 1:22:59 Join us at Vitalist Bay!

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Living Forever
Living Forever@LivingForever8·
@haider1 A meaningful life is one that has no time limits. Trying to find meaning when there is a definite end, is nearly impossible.
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Haider.
Haider.@haider1·
Sam Altman says tech nerds have failed to explain what superintelligence will actually mean for people's lives It is not enough to promise cancer cures or huge wealth if people still do not know what their own lives will actually look like What people really want is prosperity, agency, and a meaningful life for themselves and their kids
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Dani ✌️
Dani ✌️@danielsil44·
We really need death?
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Liz Parrish MBA
Liz Parrish MBA@ParrishLiz·
Researchers found that senescent cells depend on a PGAM–Chk1 interaction to boost glycolysis and survive, and blocking this interaction selectively kills these cells and reduces disease effects like lung fibrosis. scitechdaily.com/scientists-dis…
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Marcos Arrut
Marcos Arrut@MarcosArrut·
One day, a grandfather and his grandson will run the same marathon. Same age. Same body. Same biological clock. That day will come. We will make it happen. That's all.
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Keşfet

@PeterDiamandis @ScienceTM @siimland @johncumbers @velychko_s @Sierra_Lore_ @antonioregalado @BuckInstitute