Luca Stocchi MD,MBA

Great work to organize our yearly course thanks to Jana Al Hashash Jami Kinnucan Frank Farraye Mike Picco

Mayo Clinic Florida IBD course. Lots of information for gastroenterologists but also useful for surgeons

Interesting @SurgEndosc study from @MSKCancerCenter looking at patterns and detection of local regrowth in patients with rectal cancer who experience cCR after TNT and undergo watch-and-wait (2006-2020) -Suspected local regrowth occurred in 30% -Abnormal MRI with normal endoscopy was uncommon (11% of suspected regrowths) compared to Normal MRI/abnormal endoscopy (32%) and abnormalities on both MRI and endoscopy (57%) -For patients undergoing salvage surgery, the rate of pCR was 44% in the +MRI/-Endo group, 18% for the -MRI/+Endo group, and 4% for the +MRI/+Endo group. This means residual/recurrent cancer was much more likely to be present in the final specimen if the endoscopy was abnormal. -Of the 99 patients with salvage surgery and recurrent cancer on final pathology, only 1 patient (1%) had this recurrence detected by MRI alone. Important caveats: -This study goes back to 2006, and MRIs have certainly evolved during that time (as have TNT, surveillance, etc). -All false positive MRI findings occurred after 2013, suggesting newer MRIs pick up subtle abnormalities that aren't necessarily cancer regrowth. -pCR on final pathology shouldn't necessarily be considered a failure in management. These patients do very well. What I take home from this study is that isolated irregularities on surveillance MRI can be safely monitored without proctectomy in the short-term...ie you can leave the rectum in for a little while and let the problem declare itself. pubmed.ncbi.nlm.nih.gov/40659952/

Nancy You at our Grand Rounds presenting on young onset colorectal cancer

Join us for our 2nd @Mayoclinic #IBD Conference in ☀️🏖️ Florida 🐊 @MayoClinicFLGIH 📍Mayo FL 🗓️ Saturday, Nov 8 💻 Virtual option available ➕🩻 bonus Friday session with ✋🤚 on IUS session 📝👉 tinyurl.com/3emuhwpv @FarrayeIBD @ibdgijami @JGubatanMD @CrohnsColitisFn

What I heard at Grand Rounds @tsikitis -4 subtypes of CRC. Early onset CRC is not a unique subtype -TME Immune profiling different for EOCRC -early exposures + diet + microbiome + immunity/imflammation/obesity=EOCRC -normal mucosa, NOT fecal microbiome predicts adenoma formers

This is the most important study you'll see on twitter today. I'm swamped with other work, but I had to read it. Fascinating @NEJM article from @MSKCancerCenter with Longer-term data (and more patients): 6 months of single-agent immunotherapy for MMR-deficient rectal cancers, which as we all know rocked the world in 2022 with the first 12 reported patients (100% cCR). They now have 49 patients with dMMR rectal cancer (50% sporadic, 50% Lynch). All 49 developed a cCR, and 47/49 (96%) had a sustained cCR at a median f/u of 30 months. Both recurrences went back on immunotherapy and did not receive proctectomy. The study's second cohort is exploratory and has shorter f/u, but it does appear that the future of dMMR colon cancer could be non-operative as well. So exciting! @ASCRS_1 @AmericanCancer @AmCollSurgeons @coloncancertask #Coloncancer #RectalCancer #Lynch

@MayoClinicFLGIH is a proud partner of the @CrohnsColitisFn and the @takesteps #takestepsforacure walk each year We are stronger as a team and the team showed up today in numbers at the Northeast Florida Take Steps walk What do you take steps for?

@IEGecim The great Belly Dancer!!!

@LucaStocchiMD Yuca! See u in S Diego

Our research Dean Alfredo Quinones presenting at the Mayo Clinic Advanced Surgical Technologies and Robotics 2025 meeting

Dave Larson presenting on sigmoid diverticulitis at the Mayo Clinic Advanced Surgical Technologies and Robotics 2025 meeting

Amazing work! Perfect example of multidisciplinary care. Curing the incurable and making the unresectable resectable - #Colorectal #Transplant #Oncology #Hepatology. @MayoCancerCare @KrisCroome @DrDavidLarson @EricDozoisMD @Jcj84Jeremy @LucaStocchiMD

NSQIP study examining trends in surgical management of rectal prolapse in pts ≥ 70 years old--how are approaches changing? #DCRJournal discusses: bit.ly/3RjktzK @SeanLangenfeld @Neil_J_Smart @TAMISYoda @Schadi_CRS @Doc_Brown44 @slsteinmd1 @MarkSoliman @rahila_essani

@PittSurgery is now the best residency program in the nation. True pioneers in ranking & matching the best with no discrimination. 5/7 of their matched interns are IMGs. Programs that still "do not take IMGs" as categorical: time to step up & meet the 21st century! #Match2025

Wobbly chair from IKEA? Our book can help -buy it!

📣just out, new paper - mdpi-res.com/d_attachment/n… This reports impact of having a stoma within the 1st year, 43% experience stoma leakage in the preceding 2 weeks & 85% had parastomal skin complications. Strong linkage of leak to Quality of Life & mental health well being.

Textbook from the Society of Pelvic Surgeons - gynecologists urologists colorectal surgeons present on morbidity of their operations

Screening colonoscopy saves lives

Our book is out we did it