Luke Bartelt, PhD

The first and main story of my PhD research is now available on @biorxivpreprint (!!!) Let me walk you through the main takeaways of my single-cell investigation of Spinocerebellar Ataxia Type 7 (SCA7) biorxiv.org/content/10.110…

I currently have three papers in review at "high impact" journals. One of them has been sitting there for two years. In that time my daughter was born and learned how to walk, but apparently publishing a PDF was still not possible for me. For another one, after four months in review the editor told me they cannot find a second reviewer and asked me to suggest more reviewers. A third one sent me a message in 2026 saying the PDF I uploaded was larger than 10 MB and that I should please reupload everything to make the file smaller. All of this just to eventually pay between 7,000 and 12,000 USD per paper so someone can officially approve that the science we do is "legitimate". Reminder: not a single reviewer will be compensated here. I still don't understand how we as scientists can collectively be so smart when doing science and still tolerate a system like this when it comes to sharing our findings. We should move to preprints plus open review, whether human or AI, asap. So frustrated about it. I'd suggest sharing your work on bioRxiv or medRxiv, reading and reviewing preprints when you can, and highlighting good research, especially if it is still a preprint. Try platforms like ResearchHub (that pay for peer review) and experiment with AI based reviewers for faster feedback. Instead I read this as a proposed "revolutionary" measure:

It just seems implausible this is what we are made of, essentially, nanotechnology about a billion years beyond anything we can design or make ourselves.

All comes down to targeting accuracy, my intuition is that ex vivo allows verification of clean, CD8 pure material before anything is injected into a patient. We know LNPs have broad transfection profiles, adding a CD8 antibody is a nice innovation but certainly not perfect targeting. I'd rather be sure first.

Great question, Luke. “Safer” here refers to potential reductions in complications related to the ex vivo process like cell contamination, logistical delays, or inconsistent cell expansion in lab conditions. In vivo reprogramming via targeted nanoparticles could bypass many of those variables by working directly within the body’s native environment. Of course, it all depends on delivery precision and long-term data, but the promise is in streamlining the process with fewer steps and external manipulations. Would love to hear your take on the trade-offs. #BioTech #InVivoEngineering #Fibonatti

In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells. The approach showed rapid and sustained immune reprogramming in preclinical models, highlighting its promise for treating cancer and autoimmune diseases. 📄: scim.ag/3TuHwJ3 #SciencePerspective: scim.ag/3SXG15Z

@FibonattiX @ScienceMagazine How do you think this is safer than ex vivo?

@ScienceMagazine A powerful step forward in merging biotech and nanoscience. Directly programming T cells inside the body could mean faster, safer, and more personalized healing. The future of medicine is becoming more precise—and more energetic. #BioRevolution #Fibonatti #EnergyAndHealing

Exciting times in science and medicine!

The CIA analysis supporting lab origin of COVID was completed and published internally during the Biden administration. It was withheld from the public by the Biden administration in violation of the COVID-19 Origin Act of 2023, which mandated release. politi.co/4hfLpvN

It’s extremely significant that the leading German virologist, Christian Drosten, has just asserted that his high-profile rejection in 2020 of the #COVID19 research-related origin hypothesis was uninformed and wrong. It should now be clear to everyone BOTH that the manipulated scientific consensus supporting the market origin hypothesis was a travesty AND that the highly influential, unsupportable, and fatally flawed March 2020 Nature Medicine commentary re #COVID19 origins MUST be retracted. taz.de/Christian-Dros…

@codexsandy @SandwatchAI the agents are evolving

"oh this place again" Introducing $SANDY and CODEX by @SandwatchAI The first ever video framework. Powering not only agents but also merging into real-life applications. Read more in the documentation: CA: 61yG5LCoeoqzBdopXPy6BsVPTGdRXht95L68hj5ipump docs.sandwatch.com/sandwatch

Saquon pulling off moves straight out of NFL Blitz

See the full article here: cell.com/cell-reports-m…

We have been using this method to better understand the molecular features of PCs in Spinocerebellar Ataxia Type 7, and hope that this method will help any researcher studying the basic properties, or disease signatures of Purkinje cells.

I'm excited to share that this month in Cell Reports Methods, our simple and effective method for purifying Purkinje cell nuclei from the mouse cerebellum is featured on the cover! Art by: Dorota Moniuszko dorotamoniuszko.com

@whoisclydekelly Everyone should watch #TheRealDebate which showed RFK's answers to the same questions. That debate was such an embarrassment...smh

The upshot of this election debacle is it’s re-unifying the American people We have widespread agreement that neither of these men should be president

@simocristea This goes for all comparative scRNA experiments in my opinion. Multiplexing samples into the same lane is the best solution!

After 10 years, I cannot possibly understand how cancer researchers still batch-correct scRNAseq tumor patient tissue with no regrets whatsoever

Give a man a fish, and feed him for a day. Teach a man to fish, and patent your method, using the brute force of the legal system to extract royalties from otherwise general knowledge.

This is the most important video I've ever seen.

David Morens' email to @PeterDaszak: "I learned from our @NIH FOIA lady how to make emails disappear after I am FOIA'd but before the search starts so I think we are all safe. Plus, I deleted most of those earlier emails..."

Slowly but surely we are getting some accountability 🙌. The harm cannot be undone, but it can be prevented from happening again.

🚨BREAKING🚨 Today, based on evidence uncovered in @COVIDSelect's recent report, the U.S. Department of Health and Human Services commenced formal debarment proceedings against EcoHealth Alliance. EcoHealth will now face an immediate, government-wide suspension of taxpayer funds — including a hold on all active grants.