Michelle Grunin, Ph.D.

Back at ASHG and got to hear Drs Sarah Tishoff, Francis Collins, the new GLP1 MR study, the GIANT study on hwr, Dr C. Mason's lab on space flight 'omics, and that was just day 1! Excited for the rest of the week. My poster on fine mapping eQTLs of AD is today-check it out!

@RegevSchweiger @TAUMedFaculty @TelAvivUni Huge congrats and well deserved!

Very happy to share that starting October, I will begin a new position as a PI at the Faculty of Medicine @TAUMedFaculty and the School of CS & AI at @TelAvivUni. 😮

Research has been really busy, but this is out in Genome Biology! Proud to be a main analyst (yes there are a lot of us) in this largest multi ethnic study of Alzheimer disease via the ADGC. Congrats to all on publication day! doi.org/10.1186/s13059…

Happening today! Can eQTLs be useful? Are monocytes important in AMD? See you later!

Really grateful to be here at #ARVO2025. Also honored to be giving a talk on Tuesday on a TWAS + monocytes + the pathogenesis of AMD! Come find out why gene expression matters, 1:45pm, Ballroom E, Tues. Thank you to @_BrightFocus for the opportunity!

#BTS —> Team BrightFocus Foundation has arrived at the Salt Palace Convention Center in Salt Lake City for #ARVO2025—the world's largest gathering of vision researchers! We’re setting up and ready to shine a light on our initiatives to prevent, treat, and ultimately cure vision loss from macular degeneration and glaucoma. Visit us at booth 1412 to: 🔬 Explore our research funding opportunities and learn about currently supported projects. 🔎 Discover free resources, including our popular magnetic Amsler grids. 📸 Connect with our team and capture the moment. Learn more about us at brightfocus.org.

At the age of 23, before she’d even earned her PhD, Carol Greider made the discovery that would earn her the 2009 medicine prize. Along with her supervisor and co-laureate Elizabeth Blackburn she discovered the enzyme telomerase.

One telescope. Nearly 1.7 million observations. Thirty-five years – and counting. Hubble's new 35th anniversary images show cosmic sites from within our solar system to our galaxy and beyond – a reminder of the mission's impact on every area of astronomy. ⬇️

There are ~40k postdocs in the US, according to the NIH. While PhD students generally have good support (their committees, external advisors, and classmates), the postdocs do not. To help with this, we're starting the 'Postdoc Night Science' club with a first branch in NYC. ⬇️

On the dangers and ethical issues of embryo human genome editing, including multiple variants at once Editorial @Nature nature.com/articles/d4158… @NatureNV nature.com/articles/d4158… @ShaiCarmi @HankGreelyLSJU @WiringTheBrain Paper: Modeling for several diseases that lays out the potential consequences nature.com/articles/s4158…

Reflecting on another Earth year – from Mars! From saying goodbye to my pal Ingenuity to reaching the rim of Jezero Crater after a long, treacherous climb... Here are some of my biggest moments of 2024. 🧵

Going to try BlueSky. bsky.app/profile/mgruni…

But I also want to acknowledge that this was one of the main papers that Rob Igo was working on when he passed away and I am so glad to see him acknowledged as co-first author on this project. His legacy lives on as a phenomenonal researcher and great human. Thanks Rob. 2/2

I want to wish Bryan Gorman and all the co-authors (I'm part of the IAMDGC) on this paper (post below) which we all have been waiting for, 1KG imputed with multi ancestry, a huge congratulations. 1/2 thread

From @cwru: data analysis from #MillionVeteranProgram and 5 other cohorts show genetic risk for #AMD using #EHR. It helped uncover genes and pathways that boost AMD risk in one of the most diverse samples ever analyzed. @NatureGenet: go.nature.com/3Zk5xoU

It looks like there is some good news with Voyager 1 – communications have been restored, allowing the spacecraft to keep sending data back. The fact that Voyager 1 is 47 years old and still functioning and providing information to us is a testament to the quality of the research and engineering that went into its development by @NASA a half-Century ago. Voyager 1 is 15.4 billion miles from Earth – still venturing into deep space, on its own, carrying out its mission. An astounding accomplishment! space.com/space-explorat…

@engineering_joy I think it would help if the graduate student when meeting with the PI, mentions the postdoc's help. That would remind everyone that it exists.

Postdocs do a lot of invisible labor in academia. The majority of which is helping PhD students. Many of us are happy to do it, but when students fail to acknowledge that help, especially in front of the PI, it kinda kills the vibe. Give people credit for their work.

I would especially like to thank my funder @_BrightFocus, for without them, this dream wouldn't have happened. Bright Focus has let me create something huge that will be the new IAMDGC flagship and I couldn't be more grateful. @DianeB1000 @PreetiSub

Why do we need a new flagship paper for the IAMDGC? The 1st has been cited>1,500 times, but only includes Europeans. This includes participants from all populations, and is completely redone with TOPMed. There is new fine mapping, how main loci are different amongst populations🧵

The #1 question I got at ASHG was where is the IAMDGC 2.0: it's under review, but preprint is finally out! A brand new diverse ancestry analysis, two new loci, and a full TOPMed imputed dataset. I am equal first author and thrilled to see it live! 🧵 doi.org/10.1101/2024.1…