Moritz Schlapansky

Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student @MSchlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk! biorxiv.org/content/10.110…

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! nature.com/articles/s4158…

I'm looking for a #bioinformatician to join my group! Searching for someone collaborative & self-motivated with expertise in #NGS analysis. For example, functional genomics, #singlecell, splicing, RNA binding, lineage barcoding, ChIP-seq. Apply at jobs.ethz.ch/job/view/JOPG_…

How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on.. Paper @ImmunityCP: authors.elsevier.com/c/1js3h3qNrUxu…

Thank you @NatureComms for publishing my first paper and asking me about the slightly turbulent back story! nature.com/articles/s4146…

Can we reverse aging? 7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, biorxiv.org/content/10.110… we used 🧬 screens to find new rejuvenation factors🧵1/8

Ever wondered about combining 2 tissue engineered grafts? 💭Check out our latest publication in which we combine tissue engineered skin and cartilage for ear reconstruction!👂🏻 @ZenobiWongLab @AgnesKlar science.org/doi/10.1126/sc… @ScienceAdvances #ScienceAdvancesResearch

Today we @schwanklab report in @nchembio a PACE-evolved, PAM-relaxed, compact Cas9 enzyme. evoCjCas9 supports base- and prime editing, and, owing to its small size, can be delivered on single AAV vector systems. nature.com/articles/s4158… @UZH_Science @ETH_en (1/6)

🚨🚨🚨 Ever wanted to do in vivo single-cell CRISPR screens but don’t know where to start? Then check our latest publication @Nature introducing AAV-Perturb-seq. nature.com/articles/s4158… 1/🧵

Congrats, Dr. @DerGenger!! Well done. As PI, it remains a special and humbling experience to see a PhD student defend. 🦠 🌈 🙏 #virus #immunology #immunometabolism #epidemiology #phdchat #PIchat @Bergthalerlab @MedUni_Wien @CeMM_News @oeaw #Vienna

Genetic interactions reveal unexpected biology and can lead to novel therapeutics (e.g. #Olaparib). In a new preprint, John Fielder and @SMSiegner w/ @CejkaLab comprehensively unravel *all* genetic interactions in the human DNA damage response! biorxiv.org/content/10.110… 🧵

Ever wondered why hair grows excessively within your moles? Super interesting! 👇

Cells degrade unfolded proteins. But do they also check for chemical damage? We found that a C-terminal amide is completely sufficient for degradation by an SCF/FBXO31 ligase complex! With @bode_lab @matthias_muhar @jakobfarnung. biorxiv.org/content/10.110… 🧵

🎙️Excited to launch my new podcast #CRISPRli, a deep dive into the revolutionary world of #CRISPR. I'll be hosting interviews with top genome editing experts. Ideal for scientists, students or anyone curious about this cutting-edge tech. #GeneEditing open.spotify.com/show/1NDD79fy2…

I'm looking for a bioinformatician to join my group! Searching for someone collaborative & self-motivated with expertise in NGS analysis.For example, functional genomics, single-cell, splicing, RNA binding, lineage barcoding, ChIP-seq. Apply at jobs.ethz.ch/job/view/JOPG_…

Open positions for 1 PhD student and 1 Master student in our lab at the @MedUni_Wien in Vienna, Austria The successful applicants will work on advanced #pathogen #surveillance. More details: bergthalerlab.com . #Phdposition #Masterposition #Vienna #Jobs #AcademicChatter

We have a BME/MASE #PhD position open in the lab for Sept 2023! Come join us if you're interested in engineering tools to study nano-bio interactions for nanoparticle-based drug delivery systems! 🔬⚗️🧬💉💊 Deadline for application is July 1st! #newPI

Beyond proud to share the very first paper to come out of the @richardson_lab - what an honor! Special thanks to Chris Richardson (my PI/mentor) and @JulienBacal for pioneering and evolving this project with me. 🧵

All biology is computational biology. data are omnipresent, learn computational skills and you will be unstoppable. Take 5 mins to bookmark the following threads to guide your learning 👇🧵 journals.plos.org/plosbiology/ar…

The SWISSPR 2022 took place during the last 3 days. It was a great experience to meet fantastic scientists from @jcornlab, @MartinJinek, @randall_platt and @schwanklab and learn about their exciting research. Many thanks to our keynote speakers @xecoli (#GEML) and @MartinPacesa!