Marc Vincent Barcelona, MD, FPCR, DPBR-RO

@TylerSbrt7 @jryckman3 @DrVMuralidhar @VladGalatan @cpeedell @SeibertLab @IJROBP @RO_GreenJournal @ARRO_org @ASTRO_org @ESTRO_org @CZamboglou @DrSpratticus @subatomicdoc @PBlanchardMD @DrAndrewLoblaw @SbrtSean @NehaVapiwala @piet_ost @seanmmcbride Agree, 67/20 is safe+ effective (without spacers) if you keep to the DELINEATE constraints . I am not convinced that micro boosting above 40Gy/5 is useful, but others have ongoing trials in this space so we will find out. PACE-NODES will benchmark bRFS after 40Gy in VHR

3️⃣ ⛔️Crib+ ➡️ high metastatic potential! ❌No AS for crib+ ⚠️long-term DM rate 📈 after RP ✅RT group had ADT x3-6 mos 🤔Low N, but maybe ADT needed for even early-stage crib+? @urogeek @NicholasZaorsky @TonyFelefly @PaulSargos @andreasroder1 @jryckman3 @SigridCarlsson

Key finding • PSA <0.1 at 6m → 76% PSMA-CR at 12m • PSA ≥0.1 at 6m → 28% PSMA-CR Whether CMR at 12m leads to better long term control remains to be seen! Completely hypothesis generating → Dual kinetics may help decide escalation or de-escalation strategies...

Sequential radiotherapy and immunotherapy (#iRT) provided longer overall survival than concurrent iRT for newly diagnosed advanced non–small cell lung cancer, with additional benefit from chemotherapy. ja.ma/4d7QXJH

@TumorBoardTues @PGrivasMDPhD @IntegrityCE @tompowles1 @shilpaonc @montypal @cvulsteke @y_loriot @DrYukselUrun @MaxKates @Uromigos @drenriquegrande @AndreaNecchi @AmandaNizamMD @koshkin85 @apolo_andrea @MikeSerzanMD @MattGalsky @ALLIANCE_org @bergsa83 @DrRosenbergMSK @ChadTangMD @DrSpratticus 24/26 #TumorBoardTuesday 💭TMT Criteria: Ideal pt 👉 cT2-3, No b/l hydronephrosis or diffuse/multifocal CIS, Visibly complete TURBT, Unifocal tumor, Good bladder fx/capacity, No predominant variant/subtype hx ~30% risk of residual dz/recurrence post TMT; ~15% need salvage RC

A BIG BUDGET FILIPINO ANIMATED FILM?!?! This is the kind of stuff I could only dream of as a kid… I cannot WAIT and MORE FILIPINOS SHARING THEIR STORIES 🇵🇭💕

Physical activity reduces all-cause mortality in patients with cancer According to this meta-analysis including 13 RCTs👇 Exercise reduces all-cause mortality in cancer patients by 26%. Not with drugs—through exercise! cancertreatmentreviews.com/article/S0305-…

If I send you this it means just hold on, we’re going home

I dove deep into why this corgi became the undisputed mastermind and leader of the pack of 7 lost dogs- here are the key verified facts in concise points: Corgi Breed Traits That Made It Happen: Pembroke Welsh Corgis (the most common type seen here) were originally bred as cattle herders in Wales and their entire genetic blueprint is built for leading, directing, and protecting groups over long distances. Natural Leadership Instincts: Herding dogs like corgis are wired to take charge. They instinctively circle, check on stragglers, and keep the pack moving together - exactly what footage showed when it constantly glanced back to make sure the bigger dogs and the injured German Shepherd stayed in formation. Fearless “Big Dog” Personality: Despite those short legs, corgis are famously bold, confident, and assertive. Owners and trainers call them “a big dog in a small body” — they don’t hesitate to lead even when outnumbered or facing danger like highways and traffic. Top-Tier Intelligence & Problem-Solving: Ranked among the smartest working breeds, corgis excel at quick decisions and adapting on the fly. Navigating 17 km of unfamiliar expressways, fields, and obstacles while keeping seven dogs cohesive? That’s textbook corgi genius. Endurance & Low-to-Ground Agility: Their sturdy build and low center of gravity give them surprising stamina and stability for long treks, perfect for staying ahead and setting the pace without tiring out. Pack Loyalty on Steroids: Corgis were born to manage livestock as a team. That same drive turned this little guy into the ultimate pack protector and navigator. The corgi being the tactical leader is literally in its DNA. No surprise at all! For the full story of the epic 17 km escape of the 7 dogs, the fall from the truck, and the happy reunions led by Corgi, check my complete deep dive here: x.com/i/status/20361…; Who else knew corgis were secretly tactical geniuses? Drop a 🐾 if you’re not shocked! Share to celebrate these legends. Image: Not AI, first image is for the actual Corgi in this story (but image blurry) and the other images are just representation of Corgi dog breeds for clearer images

Seven dogs stolen from their owners have gone viral after escaping from an illegal transport truck and making their way home. They traveled around 17 km together, led by a corgi across highways and fields, now safely back with their respective owners..🐶🐾🥺❤️

Seven dogs stolen from their owners have gone viral after escaping their captors and making their way home The group is believed to have travelled around 17 km together led by a corgi across highways and fields

Thanks @RuehleAlex @BoekeSimon for the invitation to speak to the German #RadiationOncology #HeadNeckCancer study group on #NasopharyngealCarcinoma I will be covering: ⭐️ Implementation of TNM-9 ⭐️ Optimal treatment seq strategies ⭐️ Target Delineation from the latest consensus Welcome sign up!

Another impactful publication led by terrific incoming Rad Onc resident,@AdelZakhariaMD and our Rad Onc lead @NitinOhri3 assessing benefit of adjuvant durvalumab in LA-NSCLC using our RW database. Key conclusions by Adel/Nitin: → Durvalumab improves PFS and OS, but not in-field local recurrence → Local failures occurred predominantly at bulky disease sites (MTV >25cc) → Durvalumab's survival benefit appears driven by out-of-field disease control While paper is about out-of-field, it definitely adds to a long series of pivotal in-field contributions by our @MonteRadOnc team! ☑️dose painted xrt (PAINT/REPAINT) ☑️biomarker-guided induction therapy (SPRINT) ☑️baseline step counts as key progn factor ☑️PET imaging as best predictor of tx benefit etc w more to come! @BrendonStilesMD #lcsm

10/ Which raises the real question 👇 Instead of: EV+pembro → cystectomy Should we be asking: EV+pembro → bladder preservation?

⚡️ NICE 2026 kidney cancer guideline (diagnosis & management) — updated pathway from suspicion → staging/biopsy → risk-adapted treatment & follow-up. Striking stat: 87% of UK stage 1a RCC is diagnosed incidentally, underscoring how hard early detection is in routine practice. #KidneyCancer @OncoAlert thelancet.com/journals/lanon…

Let’s talk about prostate and urethra contouring on MRI. Three recent 📄📄📄 @SeibertLab #radonc #ProstateCancer 🧵1️⃣ @IJROBP @RO_GreenJournal @ARRO_org @ASTRO_org @ESTRO_org

Yes another study in head and neck cancer after MD Anderson , dartboard and now Torpedo show that dosimetric improvement may not always corresponds to improvement in Qol. More to it including patient factors , perception and expectations @astro @estro #ichno

@alison_tree And yet another example of obvious dosimetric advantages failing to make a meaningful difference for patients. Which lays bare our rudimentary understanding. It’s why RCTs remain essential. Most of the time, we cannot reason or hypothesize our way to the correct answers.

@jryckman3 @jfcdrr @TheLancet @marslain All caps COST EFFECTIVE reflects how these two trials were really written in different environments to achieve different goals. Torpedo is much more applicable to my practice where patients would have to travel far for proton therapy.