Marc-Emmanuel Dumas

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Data

Honoured to see our @NatureMetabolism study featured on the Ottawa Citizen front page today. We found a gut-made molecule (TMA), can switch off inflammation linked to diabetes through IRAK4. New Year tip: eat your broccoli 🥦Wonderful collabor'n with Prof Dumas @imperialcollege .

The article in the Citizen ottawacitizen.com/news/local-new… showed that gut microbiome can convert choline in legumes, broccoli or salmon to nature's solution to inflammation. @HeartInstitute @imperialcollege @MarcEDumas nature.com/articles/s4225…

The microbial metabolite TMA for the metabolic win #insulin resistance #obesity via inhibition of IRAK4 in mice #microbiome nature.com/articles/s4225…

Discovery of a gut microbiome metabolite that blocks inflammation and resistance to insulin. Its mechanism and role in improving blood sugar control may prove important treating for metabolic syndrome and Type 2 diabetes @NatMetabolism nature.com/articles/s4225…

Thanks Dan for posting this collaborative research with @MarcEDumas of @imperialcollege with our lab showing new window to address diabetes @HeartInstitute

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👩‍🔬 𝐈𝐧 𝐍𝐚𝐭𝐮𝐫𝐞: 𝐍𝐞𝐰 𝐰𝐞𝐢𝐠𝐡𝐭 𝐥𝐨𝐬𝐬 𝐝𝐫𝐮𝐠 𝐭𝐚𝐫𝐠𝐞𝐭 𝐛𝐮𝐫𝐧𝐬 𝐞𝐧𝐞𝐫𝐠𝐲 𝐚𝐧𝐝 𝐥𝐨𝐰𝐞𝐫𝐬 𝐚𝐩𝐩𝐞𝐭𝐢𝐭𝐞 – 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐭𝐡𝐞 𝐧𝐚𝐮𝐬𝐞𝐚 𝐚𝐧𝐝 𝐯𝐨𝐦𝐢𝐭𝐢𝐧𝐠 💊 Millions of people around the world benefit from weight loss drugs based on the incretin hormone GLP-1. These drugs also improve kidney function, reduce the risk of fatal cardiac events, and are linked to protection against neurodegeneration. 🤢 However, many people stop taking the drugs due to common side effects, including nausea and vomiting. Studies also show that incretin-based therapies like Wegovy and Mounjaro are much less effective at lowering weight in people living with both obesity and type 2 diabetes – a group numbering more than 380 million people globally. 🔥 In a study published in @Nature, an international team of scientists describe a powerful new drug candidate that lowers appetite without loss of muscle mass or side effects like nausea and vomiting. And, unlike the current generation of treatments, the drug also increases the body’s energy expenditure – the capacity of the body to burn calories. 💬 "While GLP-1-based therapies have revolutionized patient care for obesity and type 2 diabetes, safely harnessing energy expenditure and controlling appetite without nausea remain two Holy Grails in this field. By addressing these needs, we believe our discovery will propel current approaches to make more tolerable, effective treatments accessible to millions more individuals,” says Associate Professor @Z_GerhartHines Gerhart-Hines from the NNF Center for Basic Metabolic Research (CBMR) at the University of Copenhagen. Read more about the study, by first author @SassFrederike and Tao Ma, below 👇 cbmr.ku.dk/news/2024/new-…

it's official — 1,000,000 people have joined Bluesky in just the last day!!! welcome 🥳 bsky.app/download

Truely Fantastic work by @Z_GerhartHines and your @Metabolcenter and Embark Biotech teams over almost 10 years to identify our old NK2R as a cardiometabolic target to hit 1) energy expenditure 2) food intake and - importantly - 3) insulin sensitivity. So Proud. Move over #wegovy.

Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇

Two important papers on the gut microbiome and disease —The fecal microbial load is a key determinant confounding prior reports of association with diseases cell.com/cell/fulltext/… @CellCellPress @embl —Innovative approaches to establish causality and mechanisms science.org/doi/10.1126/sc… @ScienceMagazine

“How do you image a physical force?” @alvania of @ASCBiology is #ImagingTheFuture with a challenge to the imaging community to understand the physical forces + connections between cellular components

“Less than 0.5% percent of brain imaging articles published over the last 25 years consider health factors specific to women.” @ninamiolane of @Bowers_WBHI is changing this by using #AI digital twins of women’s brains to deepen our understanding of health. #ImagingTheFuture

@natureportfolio #CallForPapers #ArticleCollection #Metagenomics Sci Data is calling for papers for the upcoming collection "Metagenomics in marine and terrestrial aquatic environments." Learn more about the collection: go.nature.com/3NJsKLF. I’m eager to read your submission.

We are also excited to share that this work has been published today in @NaturePortfolio @NatureMaterials! Read more on our contact activation inhibiting antithrombotic coatings published in Nature Materials here: nature.com/articles/s4156…

A meta-analysis of studies covering 66 countries reported maternal, fetal and neonatal health harms associated with heat exposure, including risks of preterm birth, stillbirths, congenital anomalies and obstetric complications. @witsphr @HIGHhorizons_EU nature.com/articles/s4159…

A dedicated issue of @ScienceTM on #LongCovid —Sex-specific differences, with perspective by @VirusesImmunity and @SilvaJ_C —Insights for therapies @AndreaCoxMDPhD —Deconvoluting "Osler's Web" @MichaelPelusoMD @DeeksSteven @DrMaureenHanson @SaydahSharon —+RECOVER Trial, Lyme disease