Maria Jose Donde retweetledi
Maria Jose Donde
18 posts
Maria Jose Donde
@MariaDonde2
Wellcome Trust PhD student developing XNA precision medicine 🧬 Taylor lab, University of Cambridge
Katılım Ekim 2020
80 Takip Edilen38 Takipçiler
Maria Jose Donde retweetledi
Really enjoyed illustrating for the @sangerinstitute blog reporting the publication of the first draft #pangenome ✏️
English
Maria Jose Donde retweetledi
Very well deserved congratulations to my student @MariaDonde2 who has won one of this years’ PhD student awards from the Cambridge Society for the Application of Research (CSAR) for her work on XNAzymes! Well done Maria! csar.org.uk/student-awards…
English
Maria Jose Donde retweetledi
Excited to see this work from my PhD with @McGovernLab finally out! The revised study now includes fascinating epigenetics data from @annappios and @cw_hanna showing how HLA class II expression is initially silenced in human primitive macrophages. Check it out! 👇
English
I am very excited to share the new paper from the lab. We are using XNAzymes to cleave SARScoV2 ✂️ Many congrats to @Taylor_Lab_Cam for getting big part of this done while on lockdown!
Alex Taylor@Taylor_Lab_KCL
🚨Paper in @NatureComms w/ @pehuen87 #COVID19 hit as I started my lab, so I explored the potential of artificial enzymes to target #SARSCoV2 RNA, engineering catalytic nanostructures to chop the genome & inhibit #coronavirus replication in cells #synbio nature.com/articles/s4146…
English
Maria Jose Donde retweetledi
Have you ever wondered what the neural substrates of changing your mind are? 🤔🧠 find out in our new article: doi.org/10.1093/cercor…
@MoreinLab @CamNeuro
English
Maria Jose Donde retweetledi
English
Maria Jose Donde retweetledi
Proud to announce that my first first-author paper is online! We (@Taylor_Lab_Cam, @PhilHolliger and our co-workers) demonstrate how a novel engineered polymerase unlocks efficient synthesis and evolution of therapeutic 2'-modified nucleic acids.
nature.com/articles/s4155…
🧵(1/n)
English
@thelowlab @Taylor_Lab_Cam Thank you! Yes this side project kept me sane during my first year of the PhD so I am very happy it is out and got my first first author 😇
English
@MariaDonde2 @Taylor_Lab_Cam Congratulations Maria! Super cool to see your first paper out..
English
Check out our new paper showing how we re-targeted XNAzymes to cleave individual miR and Y RNA! Thanks to everyone involded and especially @Taylor_Lab_Cam.
Alex Taylor@Taylor_Lab_KCL
🚨 New paper in @CommsBio by brilliant student @MariaDonde2 ! We engineer XNAzymes to selectively cleave individual disease-associated non-coding RNAs (microRNAs, Y RNA) in families of similar seqs – a route to precision modulation of RNA networks? #synbio rdcu.be/cWfuE
English
Maria Jose Donde retweetledi
Engineered RNA endonuclease XNAzymes can specifically target individual disease-associated ncRNAs in vitro, with the potential for precision detection or knockdown of individual microRNAs or longer ncRNAs.
@Taylor_Lab_Cam @MariaDonde2 @Cambridge_Uni
nature.com/articles/s4200…
English
Maria Jose Donde retweetledi
🚨Article in @NatureChemistry w/ @PhilHolliger @ChrisJWan Using test tube evolution of synthetic nucleic acids we engineer artificial RNA-cutting oligo enzymes that cleave transcripts in cells w/single-nucleotide precision #synbio
chemistrycommunity.nature.com/posts/overcomi…
&
nature.com/articles/s4155…
English
Maria Jose Donde retweetledi
Delighted to share this new paper w/ @JackHervey - front cover of @rsc_chembio ! Here, we develop & evaluate systems for synthesis of pure & mixed-chemistry synthetic oligo libraries, paving the way to directed evolution of fully-biostable polymers #synbio doi.org/10.1039/D2CB00…
English
Maria Jose Donde retweetledi
I’ve published a ‘Matters Arising’ article in @NatureChemistry in collab with @PhilHolliger in which we examine a modified version of the 10-23 DNAzyme, “X10-23”, described by the labs of Profs. John Chaput and Robert Spitale (UC Irvine) – A thread (1/10) nature.com/articles/s4155…
English
Please support us this Sunday as we run the Cambridge 1/2 Marathon for @teamaruk !
Please donate below👇
justgiving.com/fundraising/ne…
Only a few pounds can go a long way.... like buying one of these tubes or paying the PhD student holding them yearly stipend !
English
Maria Jose Donde retweetledi
Ever wondered how Hofbauer cells (human fetal placental macrophages) are generated during pregnancy?
We aimed to investigate this in our latest preprint!
biorxiv.org/content/10.110…
English
Maria Jose Donde retweetledi
🚨 Interested in a @Cambridge_Uni PhD? Think synthetic biology, artificial oligonucleotides & precision medicines sound cool? Come join the Taylor lab!👽🧬
Applications now open for Oct 2021 entry to a new PhD prog in infection & immunity citiid.cam.ac.uk/students/
RTs appreciated!
English