Mark Dodding

We have new preprint on biorxiv on kinesin-1 inhibition and activation. Collaborative effort across @BristolBiochem @BristolChem with @WoolfsonLab and Christiane Schaffitzel Lab with @ProteinMotion at U Exeter 1/2 biorxiv.org/content/10.110…

and a postdoc position working between our lab and @WoolfsonLab design proteins and peptides to augment kinesin-1 activity 2/2 jobs.ac.uk/job/DMN615/res…

We have new preprint on biorxiv on kinesin-1 inhibition and activation. Collaborative effort across @BristolBiochem @BristolChem with @WoolfsonLab and Christiane Schaffitzel Lab with @ProteinMotion at U Exeter 1/2 biorxiv.org/content/10.110…

We have a new 4-year postdoctoral position available working between our lab an the @WoolfsonLab @BristolBiochem @BristolChem applying protein design approaches to control intracellular transport. More info on flyer. Get in touch!

Our paper explaining why two motor proteins that walk in opposite direction depend on each other is finally out. Great collaboration with @Carter_Lab, initiated by @zwetza, beautiful structural biology by @fe_aali. A thread 🧵 (1/9) nature.com/articles/s4159…

We have three PhD projects with motor-cytoskeleton theme though collaborations with three new(ish) PIs at @BristolBiochem supported by @SWBio_DTP with Berni Carroll (lysosome transport), @fe_aali (endocytosis) and @jessica_a_cross (protein design) see swbio.ac.uk/biomolecular-a…

Applications are now open for the Lister Prize 2025. Please apply by midnight (GMT) on Monday 23 September 2024. Start your application here: lister-institute.org.uk/how-to-apply/

@GirishRMali Congratulations Grish and team!

@AnneStraube @Jon_D_Lane One for recent @BristolBiochem graduates

Finished your Biochemistry degree, really like research, but no plans yet? Come and join us as a research assistant. We are looking for someone with experience in protein purification who wants to support our research projects on molecular motors. Apply: t.ly/Kluxa

@MAFesenko @ChisatoTsuji @BristolBiochem @UoBrisPPN Thanks Mary. Yes, there are systems where microtubules drive the formation of protrusions that are on our list. However, there are also many images in the microtubule cryoET literature, that suggest (to me at least), that these structures may form quite frequently. Will be fun...

@MarkDodding @ChisatoTsuji @BristolBiochem @UoBrisPPN Beautiful EM 🤩 I’ve loved following this story so far! Do you plan to explore intraluminal actin in other cellular contexts where the cytoskeleton is under high mechanical stress? Congratulations to all the authors 👏

Our latest paper on actin within platelet microtubules led by @ChisatoTsuji is now in print. nature.com/articles/s4146… Where else might those little turduckens 🦃🦆 be hiding? @BristolBiochem @UoBrisPPN

@AnhHLe2702 @ChisatoTsuji @BristolBiochem @UoBrisPPN Thank you! We are hoping that with demonstration that they form under physiological conditions and capacity to work with them in vitro, we can make a good case now to go after the function. Let’s see!

@MarkDodding @ChisatoTsuji @BristolBiochem @UoBrisPPN I found this so incredibly interesting and it makes sense that this would be possible. Now the question is, what's the biological function? And what proteins are responsible for threading actin into MTs?

A great collaboration with @Daniellempaul @HersIngeborg @PaulVerkade @alastair_poole labs with great support from @GW4CryoEM, funded by @wellcometrust @ListerInstitute @BBSRC and @TheBHF

We're thrilled to announce 2024's brand new #ListerFellows! @DavidsnDeathLab @bcells_rosser @nickywhiffin @AlexBoRNA @theRAD_lab @SarahDimeloeLab welcome to the fold 🥳📷 🎈 lister-institute.org.uk/welcome-2024-l…

Great to see our work on manipulating kinesin-1 activity using protein design led by @jessica_a_cross in print. In collaboration with @WoolfsonLab. @BristolBiochem @BristolChem @BrisBioDesign nature.com/articles/s4158…

Really interesting work from McKenney lab on actin-microtubule crosstalk mediated by kinesin-1 and Nesprin-2G biorxiv.org/content/10.110…

@BristolBiochem jobs.ac.uk/job/DHE659/lec…

@BristolBiochem jobs.ac.uk/job/DHE648/sen…

We have two new faculty/group leader positions available at @BristolBiochem at Lecturer/Senior lecturer /Associate Professor levels. Links below. One with a broadly defined 'omics' remit and the other anything Biochemistry, Biophysics, Molecular Cell Biology or Syn Bio. Join us!

Alexander Fellows, Andrew Carter et al @MRC_LMB show that individual #dynein motors can move the entire axon length during retrograde transport. In the anterograde direction, dynein & dynactin are transported separately, keeping them apart until required. hubs.la/Q02mfsKQ0

If you are interested in joining my group to study how microtubule motors select their cargos (or vice versa) then please see the two adverts below. One is based on neuronal cell biology, the other on reconstitution and cryoEM. nature.com/naturecareers/… nature.com/naturecareers/…