Mark Lacey 🇬🇧 🏴󠁧󠁢󠁥󠁮󠁧󠁿

@FredGaulois Well, fuck me, if you can't have a few beers and let your hair down once in a while what's the point?

Vous voyez le type en chemise blanche, dans une boîte de nuit, une bière à la main, complètement saoul et bien c’est notre Président de la République, c’était en mars 2023 durant un déplacement officiel au Congo. Macron a durant ses mandats, totalement massacré la fonction présidentielle, pas étonnant que la France soit devenue la risée dans le monde entier avec un tel guignol à sa tête !

@watergypsi Amen to that

@MakisMedicine Use cimetidine to assist with the absorption of Mebendazole into the bloodstream.

NEW ARTICLE: RESEARCH: MEBENDAZOLE in Cancer - 2025 Iran Paper - How Mebendazole overcomes Cancer Drug Resistance! 2025 Aliabadi et al - Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy Cancer drug resistance significantly reduces the effectiveness of current anticancer treatments This highlights the need for developing new multi-targeting drugs that are more cost-effective, have fewer side effects, and remain effective against cancer. Drug repurposing offers a promising solution over expensive targeted therapies. Repurposing Mebendazole: it’s already been given to millions of people at high doses with a very good safety record, repurposing it for cancer is much faster and cheaper than inventing a brand-new drug. How MEBENDAZOLE Fights Cancer and Cancer Drug Resistance. This review breaks down six key ways Mebendazole attacks cancer. Mebendazole hits all of them at the same time, which is why it may overcome resistance better than single-target drugs: 1. Disrupts the cancer cell’s skeleton (microtubules) MBZ binds to the same spot on tubulin that the cancer drug colchicine uses. This stops cancer cells from properly dividing (they get stuck in the G2/M phase of the cell cycle and eventually die).It’s similar to some existing chemotherapies but appears safer. Starves the tumor of blood supply (anti-angiogenesis) 2. Tumors need new blood vessels to grow and get nutrients. MBZ blocks a key signal called VEGFR2, so the tumor can’t build those vessels. 3. Triggers programmed cell death (apoptosis) MBZ tips the balance of proteins inside the cell (raising “death-promoting” ones like Bax and p53, lowering “survival” ones like Bcl-2 and XIAP). This activates enzymes called caspases that make cancer cells commit suicide in an orderly way. 4. Forces cells to “eat” themselves (autophagy) Autophagy is the cell’s recycling system. MBZ can ramp it up so cancer cells digest their own damaged parts until they die or become easier to kill. 5. Mebendazole wakes up the immune system It shifts immune cells called macrophages from a “tumor-friendly” state (M2) to a “tumor-killing” state (M1 type). It also increases signals that attract other immune attackers and works especially well when combined with radiation. 6. Stops cancer from spreading (anti-metastasis and MMP inhibition) Cancer cells use enzymes called matrix metalloproteinases (MMPs) to chew through surrounding tissue and travel around the body. MBZ blocks them. Additionally, MBZ calms down several overactive growth pathways that cancers use to survive and resist drugs (examples: Hedgehog, ERK/MEK, MYC, NF-κB, AKT, etc.). What the evidence shows Lab dishes (in vitro): Very low concentrations (often under 1–5 micromolar) kill or slow down breast, colon, lung, stomach, ovarian, melanoma, and brain cancer cells. MBZ works even better when paired with standard chemo or radiation. Mice (in vivo): Oral doses (10–50 mg/kg) shrink tumors, reduce the number of polyps in colon cancer models by up to 90 %, slow metastasis, and improve survival. Tumors weighed far less (e.g., one study: ~2 g vs. 12 g in untreated mice). Humans (early clinical trials): Small studies in brain tumors (Glioblastoma) and gastrointestinal cancers showed it is safe even at high doses (up to 4 g/day). One glioma trial reported median survival around 21 months when combined with standard treatment. The main practical challenge (and the fix) MBZ doesn’t dissolve well in water and isn’t absorbed very efficiently from the gut into the bloodstream or tumors. The review discusses new “drug delivery” solutions that researchers are testing: polymeric nanoparticles nanostructured lipid carriers micelles nanosuspensions These make Mebendazole more soluble, help it reach the tumor, and may let doctors use even lower doses. Main Takeaways from the Paper: Mebendazole is a strong candidate for drug repurposing in cancer because it: 1. attacks cancer from many angles at once (great for beating resistance), 2. is already proven safe and cheap, 3. works in many different cancer types in the lab and in animals, 4. shows early promise in people, 5. and can be combined with existing treatments. CONCLUSION: Overall, the paper is optimistic: Mebendazole could become a low-cost, low-toxicity addition to the cancer-fighting toolbox, helping patients whose tumors have stopped responding to standard therapies. In short, this review makes a detailed, evidence-based case that an old “worm pill” might help solve one of the toughest problems in modern cancer treatment - drug resistance - by hitting the cancer where it hurts in multiple ways at the same time.

@JacksonHarlem Written by a fucking snowflake

The Most Terrifying Bridge In America Is In LOUISIANA⁉️🤯🌉

@chinnychick Just watched your interview with Phil Campion. Late 1982 I was on MV Lycaon with an RAF Chinook crew on Operation Tantara building a radar station on Mt Alice. Would that have been Bravo November that was used to move kit off our ship? And, yes, Trump can fuck off

If Trump thinks he can take the Falklands of us…all I will say is… Hold my beer….🤬 #fuckofftangohead

@plumbingjedi @boot15_vu @KemiBadenoch Thank you mate & fuck 'em all.

I served on the same tour as Mr Woods, I was with Y coy at CIMIC house I watched my friend Ray fighting his last fight for his life after surviving multiple battles we shouldn’t have survived, sent to war by a Labour government that didn’t provide us with adequate support during the war who didn’t provide us with adequate night vision so that each man had their own device and other trials and tribulations some of which we could purchase ourselves to aid us and others we simply just had to do without, They deliberately hid from the public the level of fighting we were doing fearful it would effect the outcome of the local elections in the UK you can see it by the amount of awards and commendations issued to the battlegroup afterwards compared to the lack of media coverage while we where doing it. While we fought like lions to bring peace and security to the locals and to establish programs to aid the local communities rebuilding schools establishing clinics building infrastructure water and electricity in the face of fierce hostile actions by Iranian backed insurgents who carried out some of the most brutal horrific atrocities on the locals that still cause me nightmares to find our good names and reputation’s tarnished our hard work besmirched. To be accused of warcrimes I would expect no less of the evil monsters we fought but to have today’s senior British establishment figures encouraging the reporting of falsehoods, lies and enemy propaganda not simply out of a personal ideological hatred towards the military but for something as baseless as financial personal gain is a slap in the face of everyone of us who fought, died and bled amongst the blood and the smoke in that place. I saw the young boys of the PlayStation generation turned into battle hardened men like their grandfathers before them. Unlike their grandfathers who returned to a hero’s welcome they returned to face baseless accusations of warcrimes and brutality instigate by the likes of Hermer. It’s 22 years later and I hope and pray that we can finally have some justice. Fully restore our honour and good names as proud British soldiers of good standing and those who slandered us face the just consequences of their diabolical malicious actions. God willing the ghosts of our fallen may finally find their peace and be allowed a small measure of pride in what they sacrificed to help accomplish in that foreign land that to me will always be a little bit of England for the blood we shed to defend it.

Total respect to Kemi @KemiBadenoch Badenoch for this article who is absolutely right to call this out and take decisive action on Monday. As a veteran with over 30 years’ service, I salute her for standing up and refusing to let Lord Hermer’s disgraceful decisions put British lives at further risk. Enough is enough. Hermer’s grotesque overreach — enabling the hounding of our Special Forces with human-rights lawyers acting for the enemy — is hollowing out our elite units. One-third to half a UKSF unit under investigation? SAS operators resigning in droves? This isn’t justice; it’s betrayal that directly endangers the men and women still serving, and every veteran who’s worn the uniform knows it. Our troops deserve leaders who put them first, not quislings who tie their hands while the enemy gets legal aid on our dime. Hermer should be struck off immediately — but that’s only the beginning. Like Starmer, his actions smack of quisling behaviour: prioritising foreign claims and elite legal games over the security of British citizens and the forces who defend them. It’s time he faced proper scrutiny and prosecution for the damage done. This is the rotten fruit of nepotism and corruption that’s infected our politics for far too long. Veterans like me — and thousands more — have had enough of this corrupt, inept, and incompetent Labour government that sends our people into harm’s way without the tools, the backing, or the loyalty they earned in blood. We fought for this country. We deserve better than being sold out by those who never served and never will. Time to fight back properly. Support Badenoch and anyone willing to put Britain and our Armed Forces first.🇬🇧 I’ll be taking a keen interest on how Labour MPs react/vote - with particular attention on veterans such as @CalvinBailey @AlistairCarns @MikeTappTweets et al. Respect to @KemiBadenoch @Telegraph “Hermer’s disgraceful decisions are putting British lives in danger” telegraph.co.uk/politics/2026/…

@BigBearF1 United biscuits from the tuck shop

Without naming your age, what's something you remember from school that totally dates you? Flying blackboard, chalk filled rubbers….! 😉

@MakisMedicine The price of Ivermectin here in Thailand has risen 50% over the last year as pharmacists cotton-on. B640 ($18.50) for 12 x 6mg tablets.

GROK NEWS: Ivermectin, Mebendazole and Fenbendazole must be financially accessible to all Cancer patients and not packaged into overpriced "kits", by flight-by-night heartless corporations. Ivermectin will be available Over the Counter in Florida very soon and that will drive down prices and increase access, unlike what we've seen in other states. Once settled in Florida, I will also ensure Mebendazole prices are driven down as well. 💪 Fighting Cancer should never be about PROFIT.

@MakisMedicine Thoughts?

@muh_safrianto AI bollocks

@Maryamart011 Amen dude

@Matt_Pinner Henry

Name one

@RetroHighway Minus the toast, yes

Soft boiled eggs on toast are you a fan of this simple breakfast?

@Savage16May Once, then natural immunity took over.

Zero experimental clot shots. Zero covid

Share a random photo of your pets … they deserve to be seen

@WHATSFORDlNNER A waste bin, looks fucking rank.

If you could only add one thing, what would it be? 🤔

@NoContextBrits Two words: fucking delicious

What word comes to mind when you see this?

@Mr_Husky1 It's a butt plug. You hammer it up your arse. The string is to pull it out afterwards.

Found in grandfather’s tools Heavy metal object with rope wrapped around. can anyone tell me what this is?

@Amelia558rs 1973

What is your guess as to what year this photo was taken?

@BrainyScience Fuck off you wanker (from a Stage 4 cancer man).