Meng-meng Fu

It was fantastic to work w. Ved & Rhiju! Ved was incredibly productive & received a R21 for this work. This was a project that survived COVID, 2 lab moves, sabbatical... We're fortunate & grateful to @ZucheroLab Brad for help w. oligo cultures after I left Stanford 🙏 8/8

Combined w. work from Jackie Trotter & Doug Fields Labs, we propose a RNA switch model: - During transport, hnRNP-F binds unstructured MLS to inhibit translation. - At the cell periphery, membrane-bound Fyn kinase phosphorylates & releases hnRNP-F to initiate translation. 7/8

Excited to share our new pre-print collab w. @RDasLab! Study led by @VedTopkar brilliant MD/PhD student who used biochemistry and bioinformatics to probe the relationship between Mbp mRNA structure & transport/local translation in oligodendrocytes! biorxiv.org/content/10.110… 1/8

So this preprint opens up many new questions in astrocyte cell biology! This was a real team effort: - Postdoc Will Barclay started the project at the NIH - Postbac Johanna Bergstrom and undergrad Eva Lopez analyzed data - PhD student Lana Ho contributed imaging data

Many distal ends are enriched in GFAP. We don't know what this means yet - maybe these can become endfeet that contact blood vessels. Astrocyte processes are heterogeneous in vivo (some contact blood vessels, others contact synapses) - like axons vs. dendrites in neurons. 7/x

Excited to share our preprint on cytoskeletal organization in astrocytes! biorxiv.org/content/10.110… Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes. Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓 1/x

@NogalesLab @IsabelLAllende @UIMP @irenevalmore Congrats Eva! I love Isabel Allende! Just finished reading Violeta 🥰

Like a dream, my name next to that of @IsabelLAllende, and to be recognized my Universidad Internacional Menéndez Pelayo @UIMP. Soon after, Irene Vallejo @irenevalmore will receive the same honor. I feel proud to be linked to these truly inspiring, talented women! Thank you UIMP!

You can support the next generation of myelin scientists by funding the Myelin Gordon Research Seminar: my.grc.org/p/contribution…. @ubhjkri @MS_Focus @mssociety @NeuroForuMS @SfNtweets @GlialInitiative

Hard to quit this app because I need the cute animal videos! Any colleagues in Scotland seeing this and want to invite me to give a talk? ☺️

🗓️ Mark your calendar! Join JCB special session at #CellBio2024 with an excellent panel of speakers: @s__ellis, @LabFriedman, @Meng2Fu, @BinyamMogessie, Andrew Muroyama, moderated by @oegemadesai_lab and @timisstuck! See more info 👉 hubs.la/Q02WF1Mn0