Mark Fitzgerald

No auto tune needed … just wow.

Water is 70–80% of a cell, with our mspSA + SGAG affinity grid, we capture a near atomic (<2 Å) view showing water actively driving gene transcription inside RNA Pol II. Not just background,water is part of the machinery. Now published in Molecular Cell.doi.org/10.1016/j.molc…

@harriswangnyc @ColumbiaSysBio @ColumbiaBME @Columbia Way back when in '67 I was the dandy of Gamma Chi Sweet things from Boston So young and willing Moved down to Scarsdale Where the hell am I?

1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia science.org/doi/10.1126/sc… 🦠🧬🛠️🖥️💥

@srikosuri @harriswangnyc

Yo @harriswangnyc. Y U hate isoleucine??

Probably the greatest individual male athletic performance ever recorded.

Forever a classic

Nitrate reduction enables Sandmeyer reactions without sweat on your forehead – even on 20 mmol scale! Check out our detailed protocol in @OrgSynth and join us on the safer side of diazonium chemistry! Thanks to @MaulideLab for reproducing! 🤝 tinyurl.com/2h3earww

If you keep raising the height higher and higher, eventually... 😂

one of the best Zappa solos i’ve heard. ferocious

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue Ka-Booom! Wait for it soon to be on @biorxivpreprint #gpcr

Bikini Kill - Rebel Girl (Late Show with Stephen Colbert)

In 1969, Jethro Tull delivered an electrifying rendition of “Bourée” on the French television show La Joconde. The performance reimagined Johann Sebastian Bach’s “Bourrée in E minor” as a swinging, flute-driven exploration that defied genre and era alike.

“Machine Gun” by Jimi Hendrix is one of those solos that will still be studied a thousand years from now.

Walk with Me: Carolyn Bertozzi, Nobel Prize–winning chemist at Stanford Medicine, uses chemical biology to understand disease and develop new treatments. Hear what sparked her love of science—and the superpower she wishes she had. @StanfordUChem @Stanford_ChEMH @ChemSysBio

this is a really cool advancement with implications in molecular topology and stereochemistry. the transition state energy is high enough that these molecules are separable. americanpeptidesociety.org/research/insid…

Franz Ferdinand - Take Me Out (Live for Like A Version)

Micro-exercise breaks every hour: a feasible strategy to improve metabolic health in sedentary office workers link.springer.com/article/10.118… [A shows adherence... B shows proportion of reasons among non-adherent days. C shows final adherence distribution. Nice job! 👨‍⚕️👇]

Excited to share our work is out in @Nature! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins. nature.com/articles/s4158…