Mike Stryk

Random Song of the Day Them Bones Alice in Chains live -1993 (mtv)

@CFBKnights Plan should have been to roll with Rocco from day 1 if you ask me. Let him take his lumps early and develop in the system.

There’s a reason Chesney didn’t take him along to UCLA isn’t there?

@CoffeeBlackMD Lmaooo wtf Doc. You're gonna give him a complex

I have to collect it because his furry paws can’t work the bag but he’s gunna carry it.

@UCFSports Personally don't care. I thought it was stupid to bring him in anyway...now that we have to pay for players Play the Freshman and let him take his lumps and grow in the system.

Scott Frost provided an update on QB Alonza Barnett following Saturday's sixth spring practice: "He's doing a lot of rehabbing right now. He's throwing some, kind of on his own, mostly working with the trainers and then getting involved in meetings and on the field kind of taking reps. He's getting a lot closer and we're kind of being really cautious with him to make sure that he's 100% ready to go before we put him out there. "I'm not concerned. He's played a lot of football and he'll catch up really fast, but I don't think we're very far away from him being able to take part in it." Full press conference: youtu.be/bfS_dv-DwGg

@drpablocorral Great post Doc. Could you please elaborate or point in the direction where more about this part can be found: "Modern hypercholesterolemia is not "normal." It is an ancestral survival advantage turned pathological by evolutionary mismatch."

👉 We spend decades arguing about how low to push LDL-C 👆 Almost no one asks the obvious question: 🤔 How much LDL-C did our ancestors actually have? The evidence exists — five independent lines, all converging on the same uncomfortable answer. 1️⃣ The term newborn. Before any dietary or metabolic influence, a healthy neonate arrives with LDL-C of ~30–50 mg/dL. That is the LDLR operating without environmental interference. Everything that rises after birth is acquired. 2️⃣ The Tsimane (Kaplan et al., Lancet 2017) — forager-horticulturalists of the Bolivian Amazon — have a LDL-C between 70 to 90 mg/dL and the lowest prevalence of coronary atherosclerosis ever recorded in any human population. Five times less than the U.S. in adults over 75. And their LDL is rising as roads and processed food arrive. 3️⃣ PCSK9 loss-of-function variants. African American carriers of nonsense mutations (Y142X/C679X, ~2% frequency): −28% LDL-C and −88% CHD risk over 15 years (Cohen et al., NEJM 2006). Homozygous LOF carriers live with LDL-C of ~15–30 mg/dL. Perfectly healthy. Nature already ran the trial. 4️⃣ Evolutionary genetics. Recent positive selection signals exist on gain-of-function PCSK9 variants that raise LDL-C — likely adaptive in food-scarce ancestral environments. Modern hypercholesterolemia is not "normal." It is an ancestral survival advantage turned pathological by evolutionary mismatch. 5️⃣ Great apes in natural habitat: ~40–70 mg/dL LDL-C. Same genome. Different environment. 👆 Bonus — Lp(a). The KIV-2 repeat expansion that raises Lp(a) is a derived, recent variant. Low-Lp(a) alleles are ancestral. Elevated Lp(a) is a textbook antagonistic pleiotropy signal — possibly protective against bleeding early in life, atherogenic over decades 📍The convergent estimate: ancestral LDL-C was ~30–70 mg/dL. 📍An LDL-C of 130 mg/dL is not "normal." It is normal for a Western society in evolutionary mismatch. Targets of <55 mg/dL in high-risk patients — which still feel aggressive to many clinicians — are, ironically, closer to the ancestral phenotype than what we call "normal LDL" in daily practice. 🤔 The question is not "is it safe to lower LDL this much?" The question is: why did we let it rise this high? @society_eas @nationallipid

@5ARSociety Glad to see you guys are listening to customers. Look forward to seeing the final product

We’re about 80% done R&D-ing a DHT gel made from pharma sourced DHT Same format as Andractim, turbocharged with a penetration enhancer (not DMSO) Not fully satisfied with the bottle yet, each pump dispenses a different amount If anyone has a bottle recommendation let us know!

@jerr_rrej Time to send in the Italian boss to get shit done. Desantis has got to be the next shot at getting things done - civilly

Trump was the last democratic hope for White men. Remember, he was supposed to fix the immigration problem and mass deport. We got millions of H1B indians and the illegal latinos are allowed to stay. JD “race traitor” Vance is not going to be the guy who fixes things. Trump came in 2015 with his promises and it is 11 years later. That is almost an entire generational cycle and are demands are not being met. Politicians are shekel golems sent to delay the White man’s rage. They just want to stall the clock and allow the demographics to continue slipping away. Pretty soon White men will have to change from voting to disorder and chaos.

@AntiDoc Finding legit topical DHT is like finding a camouflaged unicorn

Bpc-157 L-citrulline Cialis Topical dht (yes, there) Lots of water Pump Gh Not constantly being in sympathetic nervous state There are barely any peptides actually in here. But ya, hypothetically, don’t ever do this that’d be nuts.

@col_a_buendia Eh, the nerds and virgins wing of White culture I guess....that slobbers all over themselves to support a half black/half asian idol. I'd rather take them to a Megadeth concert and show them where the damn Vikings come from

If anyone ever asks you what White culture is tell them to watch the Masters: decorum, deference, high trust, no theft, self-policing, good sportsmanship, prosperity, restraint, collective goodwill. It's a civilizational master class we put on for the world every year.

🚨🚨🚨Columbia law professor Philip Hamburger just dropped an essay arguing that Trump is right about birthright citizenship. That now makes at least seven prominent law professors arguing to varying degrees that Trump’s EO is constitutional. Read about this development here: open.substack.com/pub/rationally…

@RepMariaSalazar Evil. Fucking. Bitch. Dumb, too.

No it won’t. It actually locks in permanent enforcement measures (border security, mandatory E-verify, and ends catch and release for asylum seekers). None of these are currently codified in law, and until they are, they can keep being changed by the Executive. And therefore border and enforcement policy will keep changing whenever the White House changes. Participants in Dignity Program (not Amnesty) cannot become citizens and therefore cannot vote. The bill actually increases penalties for any illegal or non-citizen caught voting or attempting to vote, as well as for attempted border re-crossers, child sex traffickers, etc.

@RepMariaSalazar Man, fuck this lady right to hell where she belongs. One evil bitch.

There’s a fundamental misconception about what “amnesty” really means. Amnesty is looking the other way: no consequences, no accountability, just more chaos. That’s the system we’ve had for decades. The Dignity Act ends it with enforcement, accountability, real penalties, and ZERO tolerance for criminals. That’s not amnesty. That’s law and order!

@JamesDuncanUCF @LockedOn_UCF @mikegittens Short, quick release. Looks a little Phillip Riversish. Obv small sample here to look at but I dig it

#UCF’s 4 Star Freshman QB Rocco Marriott getting reps in practice, the young buck with some solid instincts in the pocket. ⚔️ #UCF @LockedOn_UCF @mikegittens 👀

@JesseKellyShow We're going to have to do it ourselves. That's the next realization that has be accepted enthusiastically by the millions who feel just like this

Getting closer and closer to becoming a single issue voter.

Charles Bronson still looking good for his age

@non_left_PJ_Fan @MusicPills10 Did I say PJ or did I say Eddie? Is the picture PJ as a band or is it just Eddie by himself. Good grief

@MikeStryk @MusicPills10 No, Pearl Jam was formed in Seattle and its founding members had deep roots in the scene…that is not true of STP. Though STP is often lumped in as grunge or grunge adjacent.

🥀 (credits to Ricardo Cerilo)

@CoffeeBlackMD Great points on all the right topics Doc. I don't see how weight loss, or physique in general, is anything less than the ultimate test of personal responsibility. It's a simple, but not easy, formula. And imo it's crucial for anyone trying to help others educate and enforce this

Long post. Maybe. Probably. FYI. Just some thoughts this evening after a long few days at the sick people factory. And they *are* sicker than they were a decade ago. It’s not a conspiracy. I’ve been working through a lot of ideas. Looking for a unifying framework of the mind about all things let’s call it … “better health” You all know my schtick. If I have one. It isn’t to directly sh*t on other doctors. (God bless the poor bastards) (Seriously) and act like the only knowing sage physician who “actually” cares about patients and just knows better what is going on. I am a healer. I think this was a calling. But I won’t try to make my bones by crapping on other members of the guild. It’s a tough job. I’ve been accused often enough recently of being arrogant. I don’t really think I am. But opinions are as they are. I think I’m pretty open. With a decent humility about what I know and don’t know. And. Look. Modern medicine has a lot to say and a lot of tools to help. I will never apologize for being allopathic. I use the chemicals. To treat diseases. This is a good thing. I don’t get paid by a pharmaceutical company to do so either. That’s just asinine. You guys know that right? Look. Here’s a doctor that gets paid to give talks. Ok. Look. Here’s a doctor that gets paid to consult. Ok. I’m going to make this very simple for you guys those are not normal, usual doctors. Your PCP ain’t getting sh*t from anyone for any med or any vaccine. Get a grip. Anyway. I’m trying to put together this big grand unifying theory of treatment for better health. And I’m working through a lot of these ideas. Some on the timeline. Some with the AIs available. Man. You can learn so much so fast with an AI if you know how to parse it. I’ve done statins recently. Convinced. These are tools. And good when they are good. If you don’t think so, I’m not your enemy. But. You’re wrong. But that’s ok. Never take them. If you think you need to be disagreeable about them, with me, you can f*ck right off. Currently working my way through the best way to approach weight loss. Metabolic syndromes. And insulin resistance. I’m picking up nuance fast. You can eat buttered ribeyes but it’s not magic. Nor necessary. It *is* one big energy equation. There is no way it can’t be. But it’s crafty. I’m not convinced that anyone I’ve run into yet has a unified theory. But I’ve found a lot of “this seems to often work” which is interesting to me. But also a lot of what seems too defeatist and placating. Weight isn’t (usually) a moral issue. But that doesn’t mean it’s free from individual responsibility. Which is key. But maybe also where so many miss the mark. Some by being assh*les about it. And some by abdicating what is a real locus of control. If you let it. The interventions. The when and how. Really require someone who can help on many levels. And I don’t think it’s going to be a physician. I’m too expensive to be doing that kind of micromanaging work, even if I can paint broad brush strokes. Coaches. With time. And knowledge You NEED to be both resistance training. And stressing your cardiovascular system. I think walking and running is best. I think a powebuilding protocol is best. You don’t want to be too big. You don’t want to be too thin. I sincerely believe that testosterone therapy is often the huge missing ingredient in any health improvement and weight loss approach. Roll your eyes if you want. But the best way to improve basic metabolic rate is adding muscle. Which testosterone will make happen much easier while resistance training. If you’re a weight loss doc and sleeping on testosterone, I think you should look at it closer. It’s awkward that so many “TRT clinics” are set up as cash machines. And the way some people talk about it can be hyperbolic and ridiculous. The thing is. There’s a framework here. I can really just feel it. Smell it. It’s a bit elusive still but I think I’m close. Will continue the work.

@edgaralandough Lol LinkedIn garbage lingo

6 THINGS NICE PEOPLE SAY THAT MAKE YOU LOOK LOW-CLASS (and what Magnetic People say instead) Nice People: • “No worries, take your time.” • “It’s okay, I totally understand.” • “Whatever works best for you.” • “I didn’t want to bother you.” • “Thanks again, really appreciate it!” • “I’m just happy to be here.” Magnetic People:

@FFAFamily Back when I was a teenager this lady would have gotten a nice surprise package on her porch that evening

I need these Karen’s to stop hara*sing kids for fishing. Under Florida Statue 379.104 Right to hunt and fish, we are allowed to fish and hunt. Minors under the age of 16 don’t need a license for recreational fishing. And stop touching other people’s children!!

@Geiger_Capital Speaking of which, where the hell is ICE lately? Did they all just go an extended spring break or what...

I saw it coming last year… The domestic agenda, from immigration to housing, sacrificed for Israel’s foreign policy. The Republicans deserve the midterms.