MinneBIO

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MinneBIO

MinneBIO

@MinneBio

Empowering Biotech Excellence 🌱 | Leading Supplier of Bio-reagents | Your partner in protein preparation🏆 | Let's innovate together! 💡 #BiotechInnovation

Saint Pau, Minnesota 55114 Katılım Ağustos 2023
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李老师不是你老师
李老师不是你老师@whyyoutouzhele·
台州街头“安全教育”:没戴头盔,先挨两巴掌 网友投稿:3月2日,浙江省台州市黄岩区诚新广场,一名群众因骑电动车未佩戴头盔被交警拦下检查。在执法过程中,当事人进行陈述申辩时,被交警狂扇耳光。
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MinneBIO
MinneBIO@MinneBio·
Thank you & Happy Holidays from MinneBio!
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Kami AI
Kami AI@Aiwithkami·
Which car should go first..?
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Xuyu Qian
Xuyu Qian@QianXuyu·
First lab lunch for the one-month-old Qian Lab @ChildrensPhila & @PennMedicine! Looking forward to what we will build together! 🥳🥳🥳🥳🥳
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MinneBIO retweetledi
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William A. Wallace, Ph.D.
William A. Wallace, Ph.D.@WilliamWallace·
Your immune system doesn't only defend, it remembers This diagram maps how the body’s innate and adaptive immune systems work together to identify, attack, and remember pathogens. It shows how different immune cells, antibodies, and signaling molecules coordinate to protect against infection while maintaining balance. 1️⃣ Innate immunity: the immediate response The innate system acts within minutes, providing broad defense through physical, chemical, and cellular barriers. 🟢 Example: Skin, mucus, and stomach acid block pathogens, while macrophages, neutrophils, and natural killer cells identify and destroy invaders using pattern-recognition receptors. 🟢 Example: The complement cascade amplifies inflammation and flags pathogens for destruction by immune cells. 2️⃣ Adaptive immunity: the targeted response The adaptive system learns to recognize specific antigens and produces lasting protection through specialized B and T cells. 🟢 Example: B cells release antibodies (IgM, IgG, IgA, IgE, IgD) that neutralize toxins and tag microbes for clearance. 🟢 Example: T cells coordinate and execute defense—helper T cells activate macrophages and B cells, while cytotoxic T cells trigger apoptosis in infected cells. 3️⃣ Antibody specialization and immune memory Each antibody class has a unique role in defense and long-term immunity. 🟢 Example: IgM is the first antibody made in infection, IgG provides long-term protection and crosses the placenta, IgA guards mucosal surfaces, and IgE mediates allergic reactions. 🟢 Example: Memory B and T cells remain after infection or vaccination, allowing faster and stronger immune responses upon re-exposure. 4️⃣ Active and passive protection Immunity can be acquired through natural infection, vaccination, or temporary antibody transfer. 🟢 Example: maternal antibodies passed through breast milk provide short-term passive defense. The immune system’s strength lies in its coordination—an instant, non-specific response that buys time for a targeted, adaptive defense that remembers what it has seen.
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Yisong Yue
Yisong Yue@yisongyue·
Since she's way too shy to post this herself, please join me in congratulating my amazing colleague and friend @klbouman for receiving tenure at @caltech! 🥳🎉
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MinneBIO
MinneBIO@MinneBio·
The Extracellular Matrix is a complex protein network that supports cells, regulates signaling and migration, and, together with neighboring cells and factors, shapes the microenvironment, influencing behavior in cancer, fibrosis, and tissue remodeling. minnebio.com/blog/ecm-cell-…
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MinneBIO
MinneBIO@MinneBio·
A seminar on ECM Proteomics Research by Prof Alexandra Naba from U Illinois Chicago. We greatly appreciated the insightful presentation & also thank Prof Ying Ge from U Wisconsin - Madison for organizing the seminar. minnebio.com/blog/extracell…
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CFI-UMN
CFI-UMN@CFI_UMN·
🎉 Congratulations to Dr. Brian Fife(@briantfife, @fifelab), recipient of the Dept. of Medicine Excellence in Research Award! This honor recognizes his outstanding research over the past 3 years. We’re excited to celebrate him at the Fall Faculty Recognition Event on Nov. 13! 👏
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MinneBIO
MinneBIO@MinneBio·
CD8⁺ T cells remain overactive and exhausted long after COVID-19 infection, keeping the immune system in a chronic inflammatory state. This persistent immune dysregulation could drive Long COVID symptoms by sustaining low-grade inflammation and disrupting normal immune balance.
Jon Douglas@atranscendedman

Researchers analyzed 73,000 immune cells from COVID-19 patients. They found that memory CD8+ T cells stay overactive and exhausted long after infection, keeping the immune system in a low-grade inflammatory state that may drive Long COVID. frontiersin.org/journals/immun…

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MinneBIO
MinneBIO@MinneBio·
COVID-19’s fight isn’t over; Long COVID is real and growing. Calling it an “Airborne AIDS” reflects scientific concern, highlighting the struggle to stay transparent without spreading fear—and exposing society’s deep divides over chronic illness.
David It Up!@Dave_it_up

Eight Billion COVID Infections a Year: What the “Airborne AIDS” Debate Reveals About Long COVID Advocacy (Based on : AJPM Focus study “COVID-19 is ‘Airborne AIDS’: provocative oversimplification, emerging science, or something in between?”) A strange thing is happening in pandemic politics. Some of the people who fought hardest for health justice have started drawing new lines around what we’re allowed to say. Especially when it comes to what this virus is doing to the immune system. A recent study in AJPM Focus dared to say what many researchers have been circling for years. COVID-19 can cause immune dysfunction that, in some ways, resembles HIV. Not because it’s the same virus. Not because it follows the same path. But because it leaves behind some of the same wreckage. That comparison triggered immediate backlash. The kind that shuts doors and silences people. The kind that says : how dare you even suggest that. When the Biology Gets Inconvenient Here’s what the study actually said : • SARS-CoV-2 can deplete T cells, including CD4 and CD8 subsets. • It can cause immune exhaustion and chronic inflammation. • It can damage mitochondria and impair immune memory. • It increases vulnerability to other infections. • It can persist in tissue reservoirs long after the initial infection, keeping the immune system under chronic stress. • It keeps doing this through repeat exposure, more than once a year for most people. None of this erases HIV. It highlights a pattern we’re still refusing to face. This virus isn’t just a short-term illness. It’s altering immune systems around the world, again and again, in ways we barely understand. The comparison doesn’t minimize AIDS. It says : we’ve seen this kind of damage before. We know what unchecked immune dysfunction looks like. Let’s not pretend it’s new. Eight Billion COVID Infections a Year Every year, all eight billion of us are infected with SARS-CoV-2, many of us more than once. That makes this the most widespread immune-altering event in modern history. And here’s what’s worse. The places still hardest hit by HIV, Sub-Saharan Africa, parts of Asia, the Caribbean, are also among the least protected against COVID. They have the fewest vaccines, the weakest ventilation, the least access to antivirals. This isn’t an abstract debate. It’s about real people dealing with layered crises. HIV and COVID are colliding in bodies, in clinics, in entire healthcare systems. Acting like those two pandemics are unrelated doesn’t protect anyone. It just keeps the walls up. When Silence Helps the Wrong People The backlash to these comparisons hasn’t just quieted researchers. It’s given cover to the people who want COVID to disappear from public life altogether. When advocates say it’s offensive to compare COVID to AIDS, guess who cheers. The same politicians who cut public health budgets. The same lobbyists who fight air filtration in schools. The same pundits who call long COVID “hysteria.” They use that outrage to say : see, even disability advocates think you’re overreacting. Now the scientists get attacked from both sides. Right-wing media calls them fearmongers. Left-leaning activists call them insensitive. And meanwhile, the virus keeps doing damage, quietly, steadily, globally. What Real Solidarity Looks Like If you believe in public health justice, then you don’t shut down hard conversations. You don’t tell sick people their experience is too messy to talk about. You follow the evidence, even when it points somewhere uncomfortable. The HIV movement changed the world because it refused silence. It exposed power, demanded access, and forced medicine to evolve. We need that energy again, but this time aimed at a virus infecting billions. Solidarity doesn’t mean drawing a line around one kind of suffering. It means fighting for everyone exposed to risk and neglect. The lesson from HIV was never “don’t compare.” It was “don’t look away.” Where the Pushback Comes From This response isn’t coming from bad actors. It’s coming from some of the very communities who’ve fought hardest for dignity in illness, AIDS activists, disability advocates, long-time fighters for equity. They worry, rightfully, that comparing COVID to HIV might erase the history of a brutal epidemic, or trivialize the trauma that came with it. They worry about stigma, about co-opting language, about repeating the old harms in new ways. But somewhere along the way, that caution turned into control. Into silence. Into a new kind of gatekeeping, one that says certain scientific ideas are off-limits, even if they’re true. We Lose Time Every Week Day Every day we spend arguing about metaphors is a day someone loses lung function. A day someone collapses with a reactivated virus. A day a kid develops dysautonomia and no one connects the dots. COVID is not a vibe. It’s not an opinion. It’s a biological threat that keeps evolving and spreading. It deserves the same kind of attention we once fought to give HIV. It doesn’t matter if it makes people uncomfortable. What matters is that it’s true.

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MinneBIO
MinneBIO@MinneBio·
Structure is only part of the story— ~30% IDRs. PeptoneBench & PepTron tackle this complexity: PeptoneBench connects machine learning & experiment to assess ensemble realism, while PepTron, trained on synthetic IDRs, matches BioEmu on DR & performs strongly on folded proteins.
Kyle Tretina, Ph.D.@AllThingsApx

Structure is not even half of a protein's story; ~30 % of proteins are disordered. 🧬 PeptoneBench bridges ML and experiment (CS/SAXS/RDC/PRE) to test ensemble realism. 🧬 PepTron learns from synthetic IDR ensembles, matching BioEmu on disorder while staying strong on folded proteins.

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