Ben Perry

We’re proud to announce the launch of Alys Pharma, an immuno-dermatology focused company backed with $100m financing by @medicxi and led by world leading scientific experts dedicated to developing transformative medicines for dermatology patients worldwide bit.ly/3SEhxOI

@keefstuart 1 is (possibly) Fatal Frame / Project Zero?

@demishassabis More focus on solving actual societal problems rather than rendering the world increasingly soulless would be nice.

Thrilled to share #Lyria, the world's most sophisticated AI music generation system. From just a text prompt Lyria produces compelling music & vocals. Also: building new Music AI tools for artists to amplify creativity in partnership w/YT & music industry deepmind.google/discover/blog/…

What's a perfect album that came out when you were 16?

@IanDunt Lord of the Flies? 11 is just about old enough, and it’s basically the founding text for Fortnite.

I'm teaching my 11-year-old nephew comprehension and want to read through a book with him. Anyone have any suggestions? Want to challenge him a bit, but not too much. Ideally quite actiony and boys-own-adventure. He likes Marvel films and Fortnite.

@JamesParrish Congratulations buddy!

Seven days now of being a dad. It’s been exhausting, it’s been challenging but, most of all, it’s been amazing and changed my world infinitely for the better overnight. Happy one week old, Arlo!

Michigan summer, 1/2 marathon training day #1 @runningpunks

@BShoichet @pwk2013 Agree that these should be considered as different issues. Speaking of which, will Aggregator Advisor ever be back online?

On why you should be careful when invoking structural alerts such as #PAINS filters when you criticize the work of others (re-post from 2015) #cheminformatics #MedChem #stuka fbdd-lit.blogspot.com/2015/03/litera…

The next Antiviral Drug Discovery Open Science Forum on Dec 21 focuses on Dengue, with talks from Neelika Malavige (@GMalavige) of @DNDi and Pei-Yong Shi of @utmbhealth! Register here to join: #2022-dec" target="_blank" rel="nofollow noopener">asapdiscovery.org/forum/#2022-dec

@JamesParrish That @THEBETHS album… so, so good.

This has been a pretty special year for new albums. Thank you, as ever, to the labels and artists who trust us with their music. PR is a tough job, but it's a huge help when you truly believe in the records you're working and I honestly can't remember the last time I didn't.

@jchodera @cdsouthan @covid_moonshot @BindingDb @GuidetoPHARM @DNDi Ultimately we decided to prioritise openness up to the point that it doesn't jeopardise path to registration. As @jchodera mentioned this is still very much an experiment in progress.

@jchodera @cdsouthan @covid_moonshot @BindingDb @GuidetoPHARM This entire approach was thoroughly researched @DNDi , after many discussions with hypothetical downstream stakeholders, e.g. multinationals that would consider leading the registration and holding market authorization on an IP-free NCE.

Moonshot preclinical update! We have good news to share. We have whittled down to a single advanced lead, DNDI-6510, after 6 months of intense work to optimize synthetic routes, and conduct ADMET-PK profiling, secondary pharmacology, and extensive virology... 🧵

@cdsouthan @jchodera @covid_moonshot @BindingDb @GuidetoPHARM It's a concern about well-intentioned but poorly executed experiments being run on a candidate molecule rather than scooping or willful harm. The regulatory path would still have to account for any experiments or data produced out of moonshot control.

@jchodera @covid_moonshot @BindingDb @GuidetoPHARM This was called "dirty tricks" back in the day (disclosing negative data on someone else's compound) but I don't think it happened that often

@KRHornberger (Literally) Group. Of. Death.

ROUND 1, GROUP 2

It continues... #SynthesisSaturday special edition: REAGENT ACRONYM BATTLE ROYALE ROUND ONE... 64 entrants will be narrowed to just 16 in groups of 4, with a plurality in each group advancing. 24 hours to vote. Like, RT, let's go!

It's here... #SynthesisSaturday special edition: REAGENT ACRONYM BATTLE ROYALE PLAY-IN LIGHTNING ROUND... 70 entries need to be culled to 64, so there are 6 play-in votes. Polls in the thread. Just 6 hours to vote! Like, RT, let's go!

CACHE challenge #3 is open for applications. Use receptor- or ligand-based approaches to predict molecules targeting the MACRO domain of SARS-CoV-2 Nsp3. We will test your compounds experimentally and release the data publicly. bit.ly/3zBymAT @thesgconline @target2035

@runningpunks swag turned up! #unknowntrails of the Jura

@curiouswavefn Pi (Aranofsky)

Best movie about math and mathematicians:

Fantastic and unique long-term position for synthetic medicinal chemists interested in research supervision, #training, #education and #innovation in #medicinalchemistry and #drugdiscovery. Based in @TateScience @imperialcollege White City Campus. imperial.ac.uk/jobs/descripti…

@MatToddChem @EnamineLtd @OSantibiotics @thesgconline similar to the reactivity seen for compound 12 , fig 2 on this excellent PAINS summary drughunter.com/resource/aics-…

@MatToddChem @EnamineLtd @OSantibiotics @thesgconline Be careful with those molecules, pretty sure those are known nuisance compounds / PAINS via indiscreet reactivity with cysteines (diverse cysteine attack at the electrophilic CH2 adjacent to the carbonyl, with the thiotriazole as leaving group).

Ordering from @EnamineLtd is fun (as we're doing today in @OSantibiotics github.com/opensourceanti…) but also gratifying since we're helping support excellent scientists in #Kyiv who are bravely working through dreadful Russian bombardment of their city @thesgconline