Muniesh Muthaiyan Shanmugam

Unfolded protein response (UPR), by surveillance of protein misfolding, initiating refolding or degradation & inflammation, is involved in aging. As MG is major physiological UPR activator (sciencedirect.com/science/articl…), @glo1inducer supports healthy aging. @LongevityTech @altos_labs

As we mourn loss of and celebrate life of Judy Campisi, enjoy listening to interview she did for our podcast. It’s great tutorial on #cellularsenescence and her comment on “failed experiments” is classic Judy. Details about memorial service are pending buckinstitute.org/podcasts/under…

I'm deeply saddened to share that we have lost a remarkable friend, a wonderful mentor and esteemed colleague, Judith Campisi. Judith's impact on those around her was profound and lasting. Her legacy will continue to inspire us all. Rest in peace, Judy. You will be greatly missed

Pleased to share my newest publication about OXR1, a gene that protects the aging brain, published today in @NatureComms! A thread describing the results below 👇, and here is a link to the article: nature.com/articles/s4146… @KapahiLab #Drosophila #aging #longevity #retromer

What regulates the transport of autophagosomes along the axon? In @JCellBiol, @sydneycason & @ErikaHolzbaur show that mature axonal autophagosomes are transported by the #microtubule motor #dynein, activated by JIP3/4 & regulated by ARF6 & RAB10 bit.ly/3MrP5Nw #autophagy

Reproducibility trial: 246 biologists get different results from same data sets nature.com/articles/d4158…

The 2023 NIA Summer Training @AM_OMRF was a life-changing experience! So glad to learn about grants and meet so many brilliant young scientists like @KevinMurachPhD @CoCo_Headley (my @InterSciFellows brother) @VicenziSilvia @KentLangston @mkim327 @XuZhang_Mayo @AminaAbdulAziz8!!!

@snbarmawar @eLife @KapahiLab @BuckInstitute @ellie_elegans @theElegantWorm @AM_OMRF @americanaging @ScienceNews Thanks @snbarmawar

@MuniLoveSci @eLife @KapahiLab @BuckInstitute @ellie_elegans @theElegantWorm @AM_OMRF @americanaging @ScienceNews Congratulations

Our tiny lab worms reveal big insights! My new @eLife study shows Advanced Glycation End-products (AGEs) in processed foods caused worms to overeat. Check out! doi.org/10.7554/eLife.… @KapahiLab @BuckInstitute @ellie_elegans @theElegantWorm @AM_OMRF @americanaging @ScienceNews

@beappbeapp @eLife @KapahiLab @BuckInstitute @ellie_elegans @theElegantWorm @AM_OMRF @americanaging @ScienceNews Thank you!!1

@MuniLoveSci @eLife @KapahiLab @BuckInstitute @ellie_elegans @theElegantWorm @AM_OMRF @americanaging @ScienceNews Congratulations Muniesh!!

Today we are gearing up for an unforgettable Linda Partridge Farewell Symposium with a star-studded line-up of speakers - to celebrate her legacy and say goodbye. Let's make this a symposium to remember! 🥂 #LindaPartridgeFarewell

It’s almost a rap for the 30th Annual Summer Training Course in Experimental Aging Research. What a great week!

Sudipta does such an awesome job using the fly as an AD model. Love working with this guy!

@KapahiLab got bored of regular table tennis @BuckInstitute

Please read my first author research work published in “Traffic”. pubmed.ncbi.nlm.nih.gov/35261124/

Here is my first author method paper published in Methods Mol Biol (Springer Nature) pubmed.ncbi.nlm.nih.gov/35412294/

My first author research work has been cover featured in ⁦@TrafficJournal⁩

We love glycated foods- toast, barbecue, caramel… seems like our worms like it too! And it’s produced endogenously! biorxiv.org/content/10.110…

Be careful of eating barbecued food. A simple way to reduce glycation is to cut down sugar, steam food and avoid dry heat. Excited to share the preprint of our article on how a specific endogenous AGE drives feeding behavior and neurodegeneration. biorxiv.org/cgi/content/sh…

Excited to share a preprint of our latest work on how glycation lowering compounds can reduce calorie intake increase insulin sensitivity and extend lifespan even when given late in life. 1/2 protect-us.mimecast.com/s/Pd-tCADxw6HL…