Murad Alsumat retweetledi
Why anticoagulation in DVT, PE and Antiplatelets in myocardial infarction!!
Red thrombus vs White thrombus!
1. DVT (Deep Vein Thrombosis)
》Pathophysiology: DVT occurs in the venous system, where stasis of blood, hypercoagulability, and endothelial injury (Virchow's triad) lead to clot formation.
》Clot Composition: Venous thrombi are fibrin-rich and contain lots of red blood cells and fewer platelets. These are sometimes called "red clots."
》Treatment Rationale: Since the clot is largely fibrin-based, anticoagulants like heparin, warfarin, or DOACs (e.g., apixaban, rivaroxaban) are effective—they target the coagulation cascade and prevent fibrin formation.
2. Myocardial Infarction (MI)
》Pathophysiology: MI is often due to rupture of an atherosclerotic plaque in a coronary artery, which triggers platelet activation and aggregation.
》Clot Composition: Arterial thrombi are platelet-rich, also called "white clots," formed under high shear stress.
》Treatment Rationale: Antiplatelet agents like aspirin (inhibits COX-1, reducing thromboxane A2) and P2Y12 inhibitors (e.g., clopidogrel, ticagrelor) are key to prevent platelet aggregation and subsequent occlusion of the coronary artery.
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