Muscle Regeneration

Exercise as A Biological Driver of Skeletal Muscle... : American Journal of Physical Medicine & Rehabilitation journals.lww.com/ajpmr/abstract…

An MDA-led collaboration will support research aiming to create a molecular map of human muscle regeneration. buff.ly/uk9gWsX #musculardystrophynews #musculardystrophy #musculardystrophycommunity #livingwithMD

Hibernating hamsters maintain muscle cells by suppressing muscle regeneration, via @EurekAlert! @HU_Research eurekalert.org/news-releases/…

This is HUGE: Scientists have found a way to regenerate knee cartilage and prevent arthritis. A new study from Stanford Medicine shows that blocking an age linked protein called 15-hydroxyprostaglandin dehydrogenase (15-PGDH) can restore cartilage that normally wears away with aging. In mice, inhibiting 15-PGDH reprogrammed existing cartilage cells (chondrocytes) into a more youthful, regenerative state. Cartilage thickness increased, joint structure improved, and inflammation dropped, without using stem cells. The treatment also prevented osteoarthritis after ACL-like knee injuries. Injured mice given the inhibitor for about 4 weeks avoided the rapid cartilage breakdown seen in untreated animals, which typically developed arthritis within the same timeframe. Importantly, when human knee cartilage samples from joint replacement patients were treated in the lab, researchers observed reduced cartilage degeneration gene activity and signs of renewed cartilage formation. An oral version of the same 15-PGDH inhibitor is already in early clinical trials for age related muscle weakness, suggesting a potential path toward human therapies for joint degeneration in the future.

🎧 New Base by Base episode is live: Episode 251 — MuSCs, laminin-α2 and LAMA2 MD • Activated MuSCs upregulate Lama2 and deposit laminin-α2 around proliferating cells during early regeneration. MuSCs from Lama2-def… basebybase.castos.com/episodes/muscl…

Congratulationss to Dr Dylan Chung, Prof Enzo Porrello, @GordonSLynch & Team for their new paper "Intrinsic muscle stem cell dysfunction underlies functional deficits in models of type 1 diabetes" @UniMelbMDHS @MCRI_for_kids nature.com/articles/s4153…

source qmul.ac.uk/media/news/202…

Boosting mitochondria number and function to slow cellular aging washingtonpost.com/science/2025/1… pnas.org/doi/10.1073/pn…

Check out our latest publication in @NatureComms, where we show that activated muscle stem cells remodel their niche with laminin-α2, and that the loss of this process intrinsically impairs their regenerative capacity in LAMA2-related muscular dystrophy: doi.org/10.1038/s41467…

Interesting work from @Rudnicki_Lab in @NatureComms : Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis. tinyurl.com/4byakujj

A research team is currently developing a 3D-printed heart patch designed to provide structural support while promoting the regeneration of damaged heart muscle bit.ly/48yCC6I

Franken et al. have developed a 3D tissue engineered muscle bundle model to study facioscapulohumeral muscular dystrophy (FSHD). The model recapitulates key pathological hallmarks, including DUX4 expression and reduced absolute contractile forces. tinyurl.com/4d72wad8

businesswire.com/news/home/2025… Potential trend to improved grip strength observed, with average strength across the study participants doubling from ~2kg to ~4kg

Pumps help human hearts to self-repair at higher rate – Swedish study medicalbrief.co.za/pumps-help-hum… via @MedicalBriefZA

Spiny mice are one of the few mammals with the ability to regenerate tissue, including skin, muscle, and even complex structures such as the tips of their tails, following injury. drugdiscoverynews.com/spiny-mice-hol…

Myomar Molecular - launch of its Muscle Health Test in the Canadian market - Nova Scotia to start. myomarmolecular.ca/news-release

A new mouse model of Becker muscular dystrophy institut-myologie.org/en/2024/10/18/…

New bacteria-derived hydrogel effective in muscle tissue regeneration interestingengineering.com/health/bacteri…

“On earth, sarcopenia usually takes decades to develop [in individuals] and we think that microgravity may accelerate the disease process in orders of days,” says @NganHuang on a study looking at muscle regeneration and aging in space. @HHDigital1 @ISSCR. ow.ly/4Njp50SRuEs