Natalie Trigg

Excited to have this published! We identify a subset of microRNAs acquired by sperm from the epididymal epithelium that regulate gene expression in preimplantation embryos > cell.com/cell-reports/f… Huge thanks to @ColinConine for the support and guidance during this project

If you're interested read it in @ReprodJournal ! Big thanks to the team, @ColinConine @TakuKambayashi Simon, Jordan, Maddie, Molly & Mike

The 'swollen' phenotype was from epididymal tubule breakdown and cell infiltration and was accompanied by many gene changes. Interestingly, while offspring of germ-free dads didn't show the severe swollen epididymis, they shared many epididymal gene changes.

Working with germ-free mice with the @TakuKambayashi Lab we saw a 'swollen' epididymal phenotype occurring, so we took a closer look doi.org/10.1530/REP-24…

A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice doi.org/10.1530/REP-24…

@DrAnyaArthurs @RobsInstitute Congrats Anya!

I am thrilled to share I am now a Future Making Fellow at University of Adelaide, with Prof Jose Polo and @RobsInstitute! I am so grateful and excited to work in amazing spaces with excellent researchers, including RRI fellows Dr Alexandra McCarron and Dr Bing Wang 🥳

Pleased to share my latest review article published with @SpringerNature in @NatRevUrol: Exploring the pathophysiological effects of hypoxia on testis function and spermatogenesis url.au.m.mimecastprotect.com/s/9r_1Cvl1w3T7…

This one was a big group effort! Not possible without @JESchjenken, @BrettNixon13 and the rest of the team

🔥🔥 A modest increase in temp doesn't affect sperm functionality but does alter sperm small RNAs, embryo dev and gene expression in mice plus more. pnas.org/doi/10.1073/pn…

📢Postdoc available! We are looking for curious minds to answer big questions using epigenome editing Join us at @EMBLRome - we offer training, supportive environment, top salary and scientific excellence. Also - sun, culture & Italian food😉 Info+apply: embl.org/jobs/position/…

@CTamessar from @UON_research @HMRIAustralia paper on the influence of seminal fluid extracellular vesicles (SFEV) on sperm function now published. Here we show that SFEVs deliver cargo to sperm to elicit subtle changes to their function@Repro_Fertility url.au.m.mimecastprotect.com/s/lZSZC2xMX0TB…

Interested in studying the impact of environmental stressors on sperm epigenetics? A PhD position is open to domestic candidates to work in @BrettNixon lab. See link for more details or get in contact! @UON_research @HMRIAustralia newcastle.edu.au/study/research… via @uni_newcastle

@TheBaleLab @neuronickole @EricTopol Interesting! I'll be keenly following along.

@NATrigg @neuronickole @EricTopol Thx @NATrigg. We are too! Our mouse model effects last for months, but we are seeing an evidence of a reversal in the men. Now working to look at the ‘how’! 🧫🧪

Thanks @EricTopol for the shoutout. This is an incredible translational story on how prior stress exposure alters sperm signals and function. Research that started in cells, moved to men and then into mice. Extraordinary work by first author @neuronickole. nature.com/articles/s4146…

@GoldingLab @ColinConine Thanks Mike!

This is an exciting new paper by @NATrigg and @ColinConine that examines the role of the epididymis in delivering noncoding RNAs into maturing sperm and its role in germline epigenetic programming. doi.org/10.1016/j.celr…

@neuronickole @TheBaleLab @EricTopol Thanks! Of course, I'm curious if/when/how these cells recover. Great work.

@NATrigg @TheBaleLab @EricTopol And perhaps it's also interesting to question what it means for a day 9 cell to cluster with day 3 cells, as I would expect Vd3 to be different from Vd9. Certainly questions that are also on my mind!

@HAIYANGWANG6 @NatureAging @SpringerNature Incredibly cool study!

Excited to share that my latest research on rejuvenating aged oocytes has just been published in @NatureAging with @SpringerNature! 🌟 Read here: x.com/NaturePortfoli…

@Tod_Fullston Thanks Tod!

Cool research

The first publication exclusively from my lab! Led by the amazing @NATrigg (who I will let tweet more details)

Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression dlvr.it/TCk2wx