Nazish Sayed MD, MS, PhD

Excited 2 share our new paper @ScienceTM. V show how a cancer drug disrupts blood-vessel #mechanosensing via #PIEZO1, driving #hypertension & #cardiac dysfunction & how restoring #endothelial function protects🫀 @Joseph_C_Wu @maryhawn @StanfordSurgery science.org/doi/10.1126/sc…

The ion channel protein #PIEZO1 protects against cardiac injury during #cancer treatment with tyrosine kinase inhibitor #TKI #sunitinib, according to a new study in mice and patient-derived #endothelial cells. @StanfordMed scim.ag/4pGBFPv

Excited 2 start 2026 with a review in @VMJ_SVM on #iPSC based #NAMs (#Vascular #Organoids, #multiomics) for rare vascular disease. Thx 2 Lu Liu David Wu PhilTsao @NickLeeper78 for Collab & @Joseph_C_Wu @maryhawn @StanfordSurgery 4 support. #RareDisease journals.sagepub.com/doi/10.1177/13….

#Sunitinib is an effective cancer treatment, but exposure can result in #hypertension & #HeartFailure. Dr. @Nazish_Sayed's lab at @StanfordCVI restored #PIEZO1 expression to reverse sunitinib-induced #endothelial dysfunction. 🔖 bit.ly/4s9xrBG 🗨️ bit.ly/4pOTLib

In this new @ScienceTM study from the lab of Dr. @Nazish_Sayed at @StanfordCVI, researchers identify a role for PIEZO1, a mechanically activated ion channel, in tyrosine kinase inhibitor-induced #cardiotoxicity and present a potential avenue for prevention. 🔗 bit.ly/4s9xrBG

When life-saving cancer drugs put the heart at risk New research from @stanfordcvi reveals how TKI sunitinib disrupts blood vessels’ ability to sense blood flow, driving hypertension & heart damage. Read more: med.stanford.edu/cvi//mission/n… @Nazish_Sayed, @StanfordSurgery, @ScienceTM

Thx to collaborators @amitmanhas07, Yu Liu, Noishiki, David Wu, Tripathi, Sarah Mirza, @iDilipThomas, Lu Liu, @avirupguha , Nguyen, Chen, Chitalia, Cheng, @dannysayed, @melindatelli, Karim Sallam, @Joseph_C_Wu Thx @Amanda_J_Chase for this amazing write up. cvi.stanford.edu/mission/news_c…

Excited 2 share our new paper @ScienceTM. V show how a cancer drug disrupts blood-vessel #mechanosensing via #PIEZO1, driving #hypertension & #cardiac dysfunction & how restoring #endothelial function protects🫀 @Joseph_C_Wu @maryhawn @StanfordSurgery science.org/doi/10.1126/sc…

Baszucki Research Day 2025 ✨ We welcomed Dr. Ulf Hedin from Karolinska Institute as our Baszucki Visiting Professor. From dinner with faculty & residents to a keynote on precision medicine, Biobank tour, & Grand Rounds on biobanking—what a week of innovation & collaboration! 🔬

Stanford researchers led by Drs. @NickLeeper78, @Nazish_Sayed, & @EriFukayaMD have developed an induced pluripotent stem cell (iPSC) line from a patient with varicose veins — paving the way for in vitro modeling of venous disease. 🔗: brnw.ch/21wWImM

Sharing our recent review @JMCCardiology We discuss how #LongCOVID drives cardiovascular complications & highlight the promise of #NAMs, #iPSC, #organoids & #AI in advancing diagnostics & therapies. @iDilipThomas @Joseph_C_Wu @StanfordCVI @StanfordSurgery jmcc-online.com/article/S0022-…

Came home to this beautiful surprise — truly touched by the kindness and support 🌸 Grateful to @StanfordVasc @StanfordSurgery @StanfordCVI @maryhawn @Joseph_C_Wu @RLDalmanMD for supporting this promotion! Thx #Sayed Lab and friends @iDilipThomas @amitmanhas07 @chun_liu_86

@StanfordDeptMed @StanfordMed Congratulations Karim. So well deserved.

We're proud to announce that #StanDOM's Karim Sallam has been named the 2025 recipient of the Alwin C. Rambar – James B.D. Mark Award for Excellence in Patient Care. His compassion, dedication & teamwork define excellence at @StanfordMed. Congratulations, Karim!

🧬 iPSCs shed light on vascular Ehlers-Danlos syndrome—Dr. Lu Liu brings new insights from endothelial cell modeling. @Nazish_Sayed #Holman25

Thank you @CircAHA for highlighting our recent paper on LMNA-related Dilated Cardiomyopathy. Need more studies that repurpose already FDA approved drugs for existing cardiac diseases @StanfordCVI @StanfordSurgery @SeanM_Wu @Joseph_C_Wu @josephahill @heshamasadek @American_Heart

"Teaching old drugs new tricks! Folks, our paper in @CircAHA explores repurposing olmesartan for LMNA-DCM using #iPSC-derived CMs and leveraging NIH funded @LINCSProgram data. @Joseph_C_Wu @SeanM_Wu @chun_liu_86 @maryhawn ahajournals.org/doi/10.1161/CI…

@ArunSharmaPhD @CSRegenMedicine Awesome. Congrats Arun.

Moving up a notch! Honored to become an Associate Professor at @CSRegenMedicine. Huge thanks to my incredible lab team for their amazing work. Also grateful to the leadership here, especially Clive Svendsen, for believing in me. Onwards! 🚀

Great lab and great mentor.

@HaoYin20 @NatureCVR @iDilipThomas @StanfordCVI @StanfordSurgery @maryhawn @StanfordVasc Here is the link for the paper. Please forward as needed. rdcu.be/dWWnY

@Nazish_Sayed @NatureCVR @iDilipThomas @StanfordCVI @StanfordSurgery @maryhawn @StanfordVasc A fascinating pathogenic Angiocrine paradigm! Congratulations🥳🥳🥳 Would you pls share a free reading link?🙏🙏 Behind the paywall💸

Our paper on endothelial - cardiomyocyte crosstalk in #LongCovid is now online @NatureCVR. It highlighting the importance of early vascular health monitoring in patients with #LongCovid. @iDilipThomas @StanfordCVI @StanfordSurgery @maryhawn @StanfordVasc nature.com/articles/s4416…

🏆 Congratulations to Dr. Mary Hawn (@maryhawn) of @StanfordSurgery, who will receive the 2024 Wangensteen Scientific Forum Award at #ACSCC24 this weekend! Learn more about Dr. Hawn's academic leadership and prolific scientific research. brnw.ch/21wNLt7

Research| Thomas, Noishiki et al. use thrombotic vascular tissues and cardiac organoids to show that COVID-19-induced endotheliitis and cytokine release disrupt #endothelial-cardiomyocyte crosstalk and contribute to cardiac dysfunction in #longCOVID. 👉rdcu.be/dW3Tr