Ahmed Negida, MD PhD 🇪🇬🇺🇲

I stopped correcting typos in my emails

After a sleepless night, the brain appears to compensate by boosting the activity that clears metabolic waste during normal sleep. A study of 67 people finds that this response weakens after age 40, with implications for dementia risk. In PNAS: ow.ly/GN9x50Ywt0R

A new drug 'on the block' for Parkinson’s: Tavapadon, a D1/D5 selective dopamine agonist. Randomized trial results are in and positive. Randomized means participants were assigned by chance to different groups. Pahwa and colleagues describe in their new paper in JAMA Neurology the results of a phase 3 randomized trial of Tavapadon in EARLY Parkinson’s disease. Key Points: - Tavapadon significantly improved motor symptoms as measured by MDS-UPDRS II and III scores compared to placebo over 26 weeks. - Clinical benefit emerged as early as week 5 and was sustained through the duration of the study. - The drug demonstrated a favorable safety profile, w/ most adverse events mild to moderate including nausea, headache and dizziness. My take: This is an important study that brings a D1/D5 selective dopamine agonist into the spotlight. The idea of targeting D1 pathways while potentially avoiding some of the D2/D3 related side effects is compelling. However, we should be cautious as longer term data will be critical to understand durability, safety and real world impact. Here are 5 points that resonated w/ me: 1- Early Parkinson’s disease remains a window where smarter therapies could meaningfully alter trajectories. 2- Selective D1/D5 agonism represents a different pharmacologic strategy compared to traditional dopamine agonists. 3- The magnitude of motor improvement in this trial appears clinically meaningful and not just statistically significant. 4- Side effects were frequent, however mostly manageable, and this balance will matter in early disease decision making. 5- The future will hinge on long term safety, comparative effectiveness and identifying which folks benefit the most. cutt.ly/btIYBwr3 @JAMA_current @JAMANeuro

Harvard researchers had 12 people read on an iPad for 4 hours before bed. For 5 nights straight. Then they measured what happened to their brain chemistry. Here's what screens before bed are really doing to your body:

Close-minded people who are easily threatened by contradictory information might be the most likely to cling to false beliefs. In a large global study (N = 49,968, 68 countries) we found that the open-mindedness aspect of intellectual humility was the strongest predictor for rejecting conspiracy beliefs out of 17 potential individual difference measures. Specifically, people who were not easily threatened (disagreeing with items like "Only wimps admit that they've made mistakes") were the least likely to hold conspiracy beliefs about the pandemic. The lesson: Keeping an open-mind might be one of the best paths to the truth--especially if you are willing to own up to your errors. osf.io/preprints/psya… Led by @philipparnamets @moral_psych @Robert_M_Ross

New paper in Imaging Neuroscience by Lautaro J. Aguzin Parrilli and Martin A. Belzunce: Bias and generalizability of brain age prediction models: A multi-cohort evaluation with anatomical and interpretability insights doi.org/10.1162/IMAG.a…

ADHDer's dream job: Being a Professional Idea Generator. Giving Unlimited ideas with absolutely no responsibility for implementation.

Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity | PNAS #sec-3" target="_blank" rel="nofollow noopener">pnas.org/doi/10.1073/pn…

Vinay Prasad, the US Food and Drug Administration chief medical and scientific officer, will leave the agency for the second time, amid a series of disputes with pharmaceutical companies bmj.com/content/392/bm…

🫀What is the relationship between adult cardiorespiratory fitness (CRF) and dementia risk? 🫀 Newly published research in #DADM demonstrate high CRF is longitudinally associated with a lower risk of late-onset dementia (🧵1/2) Full Article: alz-journals.onlinelibrary.wiley.com/doi/10.1002/da…

@a7mad_elsa3ed ربنا يبارك فيه و يحفظه من كل سوء

الدكتور هيثم يشرفني إني واحد من فريق عمله هو اللهم بارك طبيب بشري ومدير لعدد من المشاريع الدعوية والتجارية وله عدد ضخم من الكتب المنشورة في السوق يعني بيه ابن بيه من يومه ، مش متسول زيك ياض ياملحد وباع دينه من أجل رشة فلوس من داعميه 😎😉

@TheCleanCarClub Messi of driving haha

Best driver in the world🚗

Scary progress

New paper in Imaging Neuroscience by Diego A. Caban-Rivera, Curtis L. Johnson, et al: Mechanical properties of white matter tracts in aging assessed via anisotropic MR elastography doi.org/10.1162/IMAG.a…

"You need Proof of Work to get a meeting with a busy person." @naval

The human brain isn’t designed to process all of the world’s breaking emergencies in realtime.

Important paper by @EricTopol and colleagues in Nature Metabolism: Obesity as a catalyst for neurodegeneration. Compelling synthesis of how midlife obesity may drive brain-wide reprogramming—impacting neurovascular coupling, BBB integrity, CSF dynamics, metabolism, and myelination—potentially accelerating neurodegenerative vulnerability. Worth a read. @EricTopol @DeepakBhattMD @JavedButlerMD #Obesity #Neurodegeneration #BrainHealth #CardioMetabolic #PrecisionMedicine #PublicHealth #obesity #ozempic

📊 JAMA Guide to Statistics and Methods: The Hochberg procedure is a multiplicity correction used in clinical trials to control the familywise error rate when comparing multiple end points. Learn more: ja.ma/4ctfEjw

This is the corpus callosum, one of the major white matter tracts in the brain. It's one of the tracts we looked at in our white matter study, where we found differences in autism: bit.ly/4aT2r2f

Short-form video may alter your brain in ways similar to drug addiction. This EEG study found short video addiction weakens the frontal lobe, the same region impaired by substance abuse. Here's what that means for anyone who scrolls daily: