Sabitlenmiş Tweet
My latest paper, “An FGF Timer for Zygotic Genome Activation” is now published in Genes & Development.
genesdev.cshlp.org/content/early/…
English
Nicholas Treen
126 posts
Nicholas Treen
@NicholasTreen
Developmental biologist studying Ciona embryos. Postdoc in Levine lab. Princeton University Catalysis Initiative Fellow
Princeton, USA Katılım Ekim 2021
340 Takip Edilen318 Takipçiler
Nicholas Treen retweetledi
What if you could deliver molecular tools directly into oocytes without microinjection? In our new paper, online today @Dev_journal (doi.org/10.1242/dev.20…), we introduce VitelloTag, a new cargo delivery tool to enable injection-free genome editing. 👇Read on for a short 🧵
English
Nicholas Treen retweetledi
Chromatin scientists, want to reorganize genomic loci as you wish?
Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/…
English
Nicholas Treen retweetledi
Kudos!👏 to Harsha Sen, 3rd-year grad student in @R_Mallarino lab, awarded Best Student Talk in Division of EvoDevo Bio at 2024 meeting of Society for Integrative and Comparative Biology #SICB2024. The talk: "Molecular evolution and development of the mammalian gliding membrane."
English
Nicholas Treen retweetledi
A clever strategy for multiplexed immunolabeling out today from Peng Yin's lab. "Thermal-plex" uses DNA probes that fluoresce sequentially when, and only when, activated with transient exposure to heating spikes at designated temperatures. nature.com/articles/s4159…
English
The fruit fly Drosophila melanogaster- expertly illustrated by Mike Levine
English
Nicholas Treen retweetledi
New paper alert! Working with @CALM_STP @TheCrick @Princeton we have developed a method to stage zebrafish embryos using deep learning 💻📷 Many thanks to my co-authors David Barry and Matt Renshaw, as well as @veni_menon,@rburdine1 @glaevsky and Danelle Devenport 💙
LifeScienceAlliance@LSAjournal
Need to stage Zebrafish embryos? Don't want to do it manually? Try KimmelNet. @RebAnnJones @CALM_STP @TheCrick @Princeton life-science-alliance.org/content/7/1/e2…
English
Nicholas Treen retweetledi
Very happy to have this research project from my postdoc with @EKfarley out in Dev Cell!
We wondered if single-nucleotide variants within heart enhancers can affect enhancer activity and phenotype.
Developmental Cell@Dev_Cell
Online now: Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development dlvr.it/SxWzX8
English
Nicholas Treen retweetledi
Delighted to share our new pre-print and introduce the mTurq2-Col4a1 mouse model in which collagen IV is endogenously tagged - thanks to all authors! A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model biorxiv.org/content/10.110…
English
Nicholas Treen retweetledi
Nicholas Treen retweetledi
So excited to join the Dept of Biochemistry & Molecular Biophysics @ColumbiaBiochem and the Program for Mathematical Genomics!!! I am extremely grateful to Stavros and many others for the warm welcome, and greatly looking forward to learning, discussing & collaborating together.
LomvardasLab@LomvardasLab
Supper excited to welcome Dr. Michal Levo at our department. Her elegant and creative approaches in the study of genome architecture and gene transcription will shed new light to the understanding of enhancer-promoter interactions and transcription dynamics in development!
English
Nicholas Treen retweetledi
Delighted to share a short review article published in @ScienceAdvances!!
Enhancer dynamics: Unraveling the mechanism of transcriptional bursting.
science.org/doi/10.1126/sc…
English
Nicholas Treen retweetledi
Nicholas Treen retweetledi
How do distal enhancers control transcription dynamics in living cells? Check out our latest work published in @MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. cell.com/molecular-cell…
English
Nicholas Treen retweetledi
Levine lab reunion! It was great to see my former colleagues in Princeton, Nick @NicholasTreen João @J_Raimundo_ Laurence and Bomyi!!
English
My image was featured on the cover of the latest issue of Genes & Development!
You can read the paper here:
genesdev.cshlp.org/content/37/3-4…
English
Nicholas Treen retweetledi
In this study, @NicholasTreen et al. describe a temporal transcriptional switch in the chordate embryo, regulated by FGF signaling. Read more about it here:
➡️genesdev.cshlp.org/content/early/…
English
Nicholas Treen retweetledi
Nicholas Treen retweetledi
Happy to announce publicly that I was awarded a K99/R00 from NCI! Big thanks to Proud Cliff Brangwynne @brangwynnelab and my co-mentor on this project Cigall Kadoch @CKadoch
Looking forward to big discoveries!
English