Takashi Fukaya

How do distal enhancers control transcription dynamics in living cells? Check out our latest work published in @MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. cell.com/molecular-cell…

Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. nature.com/articles/s4158…

再来週です、是非気軽にご参加ください！

Online Now: Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET dlvr.it/TSVTdL

1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. doi.org/10.64898/2026.…

Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles dlvr.it/TSRVyd

MicroSplit: a computational unmixing method for multiplexed fluorescence imaging of up to 4 structures per imaging channel. @ashesh0 @florianjug nature.com/articles/s4159…

1/ Preprint alert 🚨🚨🚨 How do cells decide where an mRNA should end? And how is that decision coordinated with splicing and transcription while the RNA is still being made? Here's what first author @HopeMerens found 👇

Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models Impactful biophysics research from @BiophysJ (@BiophysicalSoc) hubs.li/Q04f4VzN0 @CUBIOCHEM1 @BioFrontiers

(1/n) Super excited to share that our preprint is out today in @NatureSMB with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: nature.com/articles/s4159… MIT NEWS: news.mit.edu/2026/how-chrom…

@NilimeshDa6026 Thank you!!

@FukayaLab This is really elegant model, might be hard to test, but really excellent, and makes sense

New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. biorxiv.org/content/10.648…

@GallowayLabMIT Thanks!!

@FukayaLab That's very interesting!

Elegant. Pol II–Mediator complexes connected through chromatin behave like surfactants, where enhancer–promoter proximity stabilizes a transient micelle assembly. This cluster corresponds to the transcriptional ON state, & micelle disassembly corresponds to the OFF state.

我が家の1歳児が選んだ色のペンキを、刷毛でぺっぺっと(親が真剣に)キャンバス地へ飛ばして作製。

@k2_sakaki ぜひ遊びに来てねー

楽しそう！ 深谷さんが「研究者とは何か」とか「研究を伝えることとは何か」をどう語るんだろう？

@YoshihoIkeuchi 遊びに来てくださいー

なにこれたのしそう

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

More excited to read this paper than a kid on Christmas morning. Huge congrats @GallowayLabMIT !!! Christmas has finally come. science.org/doi/10.1126/sc…

池上さん、桝さんと一緒に定量研サイエンスカフェにてお話しします。参加無料ですので、是非気軽にお立ち寄り下さい！ 事前登録: forms.gle/4n1tHkAxtioUNg…

Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. cell.com/cell/fulltext/…