PCF_SELECT

370 posts

PCF_SELECT

@PCF_select

Multidisciplinary team working together to develop, validate, and implement liquid biopsies to improve the lives of patients with prostate cancer.

Katılım October 2016

43 Takip Edilen416 Takipçiler

2026 Yıllık Özeti

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PCF_SELECT@PCF_select·Jun 1

.@PCF_SELECT #cfDNA assay detects #allelicimbalance (e.g. BRCA2, ATM, PTEN) in #prostatecancer plasma with high sensitivity. Consortium of @FrancescaBZNY @AttardLab @mishabeltran @ResearchWyatt @MarkARubin1 labs and teams! @PCF_Science @AIRC_it @CR_UK academic.oup.com/narcancer/arti…

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Maite Bourlon@BourlonMaite·Apr 29

The #IPCS26 @APCCC_Lugano with wonderful data in #prostatecancer 1️⃣Liquid biopsies 2️⃣Neuroendlcrine differentiation 🔵Epigenetics 🔴NEMO: Neuroendocrine monitoring panel 🟢Targeting methylation @Silke_Gillessen @mishabeltran @DanaFarberNews @RodRogSan @feresparza06

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Michael Hofman@DrMHofman·Jun 2

Clonal hematopoiesis (CH) in the @ANZUPtrials #TheraP study @ASCO #ASCO25 presented by Asli Munzur ■ ¹⁷⁷Lu-PSMA-617: higher incidence of emergent CH compared to cabazitaxel chemotherapy ■ Most new clonal hematopoiesis mutations ¹⁷⁷Lu-PSMA-617 fall in DNA damage repair response genes PPM1D, TP53, ATM, and CHEK2. ■ Clinical significance unclear but may become more relevant as radioligand therapy moves into earlier lines of treatment @ResearchWyatt @AzadOncology

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pas_rescigno@PasRescigno·Oct 23

Quick overview of news in Prostate Cancer from Esmo with @Ecastromarcos @AttardLab and Axel Heidenreich Please follow ecancer.org/en/video/12526…

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Bernard-Tessier@alicebernardt·Feb 3

Just out today in @jclinicalinvest 🚀 mHSPC is not one disease, but a kaleidoscope of biological states. We highlight what we know — and the key gaps that remain — on the road to precision medicine✨ Led by my mentor @mishabeltran 🙌 #ProstateCancer #mHSPC #PrecisionOncology

Journal of Clinical Investigation@jclinicalinvest

Exploring the biology of metastatic hormone-sensitive #ProstateCancer: on the road to precision medicine In this Review, Alice Bernard-Tessier & Himisha Beltran @mishabeltran @danafarber discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI200…

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Misha Beltran@mishabeltran·Mar 5

Excited to share our new paper @NatureComms in collaboration with @RickmanLab, led by #RichaSingh @WeillCornell and @Bajji @DanaFarber #BeltranLab

Dana-Farber News@DanaFarberNews

New research published in @NatureComms provides critical mechanistic insights into how prostate cancer becomes resistant to treatment, uncovering how two key epigenetic mechanisms - DNA methylation and EZH2 activity - work together to drive transformation to a more aggressive form of the disease, neuroendocrine prostate cancer. @DanaFarber @bajji @mishabeltran Read more: bit.ly/4sk61bg

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UroToday.com@urotoday·Jun 8

Understanding ctDNA technology applications for cancer detection and characterization. @ResearchWyatt @VanProstateCtr joins @UroDocAsh @MDAndersonNews to break down the fundamentals of cell-free DNA and how ctDNA represents the tumor-derived portion of these fragments in the bloodstream. #WatchNow on UroToday > bit.ly/42EeUm4

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Misha Beltran@mishabeltran·Jul 1

Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer @NatureComms rdcu.be/euijO Team science led by Kei Mizuno #BeltranLab @DanaFarber_GU @PCF_Science

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Francesca Demichelis@FrancescaBZNY·Jun 17

Favorite study! Germline-somatic tandems dictate cancer subtypes, provide clinical insights, and fuel molecularly informed studies. Kudos: Blerta Stringa, @Paola_Gasperini, Alessandro Alaimo, and @LunardiLabCIBIO (co-last a!) @NimaSharifiMD doi.org/10.1158/2159-8… @UniTrento

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Michael Hofman@DrMHofman·May 27

Stunning research from @EdmondMKwan on ctDNA in theranostics: 🧬Low ctDNA predicts better response with ¹⁷⁷Lu-PSMA-617 vs. cabazitaxel chemotherapy ⚠️PTEN alterations linked to worse outcomes on cabazitaxel 🧪ATM defects tied to favorable PSMA-617 results 🩻PET quantitative biomarkers (SUVmean) are additive 🌟We identify new candidate biomarkers for ¹⁷⁷Lu–PSMA-617 selection and ultimately expand the mCRPC predictive biomarker repertoire Online at @NatureMedicine nature.com/articles/s4159… @ANZUPtrials #TheraP @MovemberAUS @PCFA Support by @PCF_Science Challenge Award @ResearchWyatt @AzadOncology @Prof_IanD

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Toni Choueiri, MD@DrChoueiri·Feb 15

Elegant presentation from @ResearchWyatt on the evolution of ctDNA detection and characterization! Session chaired by @DanaFarber_GU's @OncoBellmunt and @BartsECMC 's @b_szabados #GU25 @ASCO @OncoAlert @OncLive

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Francesca Demichelis@FrancescaBZNY·Sep 23

Exciting work ahead on Large #Oncosomes at the @UniTrento @CIBIO_UniTrento with our team #DemichelisLab, Dolores Di Vizio @doldivizio at @CedarsSinai and Shannon Stott @svploeg at @MGH_RI funded by the @theNCI #PLUS

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Francesca Demichelis@FrancescaBZNY·Dec 27

Proud of our LIG1 loss/PARP inhibition #SL study in @jclinicalinvest by @GiuliaFracassi_ an @AIRC_it fellowship awardee and @FraLo05 a @PCF_Science YIA Collaborators: @quimmateo @FdAdF66 Relevant to #prostatecancer and beyond. Download it! jci.org/articles/view/…

Giulia Fracassi@GiuliaFracassi_

🚨 New Preprint Alert! 🚨 I’m thrilled to share our latest study now online on JCI:  CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer. 🔬 Check out the preprint here: doi.org/10.1172/JCI179… Huge thanks to @FrancescaBZNY, @FraLo05, all Demichelis’ lab members and facilities staff at @UniTrento @CIBIO_UniTrento, and key collaborators @quimmateo, @FdAdF66 and Helmut Klocker. Special thanks to Fondazione Trentina per la Ricerca sui Tumori, @AIRC_it fellowship, @ERC_Research, @PCF_Science, and MIUR. #ProstateCancer #CRPC #LIG1 #PARPi #Biomarker #SyntheticLethality #PrecisionMedicine

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Toni Choueiri, MD@DrChoueiri·Dec 20

PROSTATE Paper 2 Franseschini et al. developed a targeted DNA methylation assay for the detection of neuroendocrine prostate cancer using plasma cell-free DNA with an AUC > 0.93. Their assay also quantifies tumor content and offers a phenotype evidence score, which reflects various CRPC phenotypes. @CD_AACR . Lead our own @mishabeltran @DanaFarber_GU aacrjournals.org/cancerdiscover…

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Toni Choueiri, MD@DrChoueiri·Dec 13

Heartbroken💔we lost Dr. Felix Feng— close friend, selfless collaborator, brilliant scientist & a man who saved many prostate cancer lives with a triad of generosity, kindness, & teamwork. We miss you @felixfengmd --too early my friend. To all: please consider supporting this @ASTRO_org @AmericanCancer award in Felix name: donate.cancer.org/g/tjjfqwdnrxrl…?

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Andrea Miyahira@AndreaMiyahira·Dec 11

Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️

Josh Lang@JoshLangMD

Tonight we sit with the cherished memories of a truly unforgettable individual who changed the lives of so many fighting cancer. Tomorrow we stand and get back to the fight against the terrible disease that took one of our best, brightest, and kindest. Love you forever, Felix.

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Andrea Miyahira@AndreaMiyahira·Dec 11

The last time Felix stood on our stage, after a beautiful talk by @mishabeltran & intro by @AminaZoubeidi 💔💔💔 vimeo.com/1037583309/b7d…

Andrea Miyahira@AndreaMiyahira

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Dolores Di Vizio@doldivizio·Dec 11

A tremendous loss for the cancer scientific community. @felixfengmd truly was one of the very best. I feel fortunate to have had the chance to meet him. This is heartbreaking but I want to remember him with the smile that always lit up his face 💔@MaryFengMD 💔

Josh Lang@JoshLangMD

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Vancouver Prostate Centre@VanProstateCtr·Sep 19

Exciting news! Dr. Alex Wyatt, a senior research scientist at the Vancouver Prostate Centre, is now the scientific director for the Clinical Cancer Genomics Program at BC Cancer. @ResearchWyatt prostatecentre.com/news/dr-alex-w…