The PULSE-MI trial

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The PULSE-MI trial

The PULSE-MI trial

@PULSEMI_trial

Prehospital single-pulse-dose steroid in patients with STEMI 🚑 🫀 An investigator-initiated, 1:1 randomized, blinded, placebo-controlled trial

Rigshospitalet Katılım Kasım 2022
62 Takip Edilen89 Takipçiler
The PULSE-MI trial retweetledi
Ignacio Seropian MD
Ignacio Seropian MD@ISeropianMD·
👏 👏 to the @PULSEMI_trial inv!! A “negative” trial that is v important for sev reasons: 1) There’s an old belief that GC are ☠️ in #AMI 2) Some surrog of impr outcome We can say there’s no harm 💪….Somenthign we’ve been writing with @AbbateAntonio & @bvantassell some yr ago
JAMA Cardiology@JAMACardio

Results of the PULSE-MI trial show that in pts with STEMI, prehospital pulse-dose glucocorticoid did not reduce final infarct size after 3 mos. Patients treated with glucocorticoid had higher acute LVEF, reduced acute infarct size, & less MVO. ja.ma/4g4H5zi #ESCCongress

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Jasmine Melissa Marquard
Jasmine Melissa Marquard@JasmineMarquard·
WHAT A MILESTONE! On behalf of everyone behind the trial, I just presented the results of the @PULSEMI_trial at #ESCCongress 🚑 Prehospital glucocorticoid did not reduce final infarct size BUT it is safe, ⬆️ acute LVEF, ⬇️ acute infarct size and MVO! Read the more in @JAMACardio
Jasmine Melissa Marquard tweet mediaJasmine Melissa Marquard tweet media
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JAMA Cardiology
JAMA Cardiology@JAMACardio·
Results of the PULSE-MI trial show that in pts with STEMI, prehospital pulse-dose glucocorticoid did not reduce final infarct size after 3 mos. Patients treated with glucocorticoid had higher acute LVEF, reduced acute infarct size, & less MVO. ja.ma/4g4H5zi #ESCCongress
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JAMA
JAMA@JAMA_current·
From @JAMACardio: Results of PULSE-MI trial show in pts w/ STEMI, prehospital pulse-dose glucocorticoid did not reduce final infarct size after 3 mos. Pts treated w/ glucocorticoid had higher acute LVEF, reduced acute infarct size, & less MVO. ja.ma/3XnD2GT #ESCCongress
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RigsHeart 🫀🚨
RigsHeart 🫀🚨@RigsHeart·
@JasmineMelissaMadsen presenting results from the #RCT #PulseMI MI size was not reduced by iv. glucocorticoid prehospital 🚑💉
Fredrik Folke@FolkeFredrik

European Society of Cardiology Congress 2024 in London has begun 🔥❤️ - and with a great presentation on the PulseMI trial from Jasmine Melissa Madsen! ➡️ No reduktion in myocardial infarction size by i.v. glucocorticoid given prehospitally @akutberedskabet

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The PULSE-MI trial
The PULSE-MI trial@PULSEMI_trial·
Dr. @laustemil just presented the primary results of #STEROHCA; An RCT investigating the effect of pulse-dose methylprednisolone in patients with OHCA! These findings are intriguing!! We have now seen the results on brain injury and inflammation. What about #MyocardialInjury? 🫀
Tommaso Scquizzato, MD@tscquizzato

@laustemil Methylprednisolone 250 mg compared to placebo after ROSC in 120 OHCA patients was safe, reduced IL-6, but had no effect on brain injury and outcomes #LIVES2023 #STEROHCA @laustemil

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The PULSE-MI trial
The PULSE-MI trial@PULSEMI_trial·
WHAT A #MILESTONE!! After JUST 11 months - today the last patient was randomized in the PULSE-MI trial! 🫀🚑 The last FU will be completed in January 2024! ✅ We are excited to share the results on the trial in the beginning of 2024! 🫀 #CardioTwitter #RCT @RigsHeart
The PULSE-MI trial tweet media
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RigsHeart 🫀🚨
RigsHeart 🫀🚨@RigsHeart·
#Thread 2/4 // The @PULSEMI_trial 🫀🚨 Hypothesis: In #STEMI patients, pre-hospital 🚑pulse-dose #methylprednisolone prior to primary #PCI will: ⬇️inflammation 🧫 ⬇️reperfusion injury ⬇️final infarct size 🫀 Subsequently resulting in: 📈impoved clinical course following #STEMI
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The PULSE-MI trial
The PULSE-MI trial@PULSEMI_trial·
Status at 8 months 1. 390 eligible patients included 🚑 2. 300 acute #CMRs 🏥 3. 195 follow-up #CMRs 🫀 52% down, 48% to go!
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The PULSE-MI trial
The PULSE-MI trial@PULSEMI_trial·
We just completed the 131st follow-up CMR scan (35%)! The inclusion of this trial has and is incredible! 🫀🚑 Yet, it could not be possible without #teamwork all across the board! 🙏🏽 We expect to have completed the enrollment by the end of July at latest! 🥳 #RigsHeart @RigsHeart
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The PULSE-MI trial@PULSEMI_trial·
A total of 102 (27%) patients have now completed the 3-months follow-up #CMR! A huge milestone! 🫀🚑 #RCT
The PULSE-MI trial tweet media
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Keşfet

@AbbateAntonio @bvantassell @JAMACardio @EmilHolckMD @laustemil @CHassager @engstr_thomas @FolkeFredrik