Patricia Yuste

Structural & functional analysis revealed that the extracellular #chaperone #clusterin functions through two hydrophobic tails in preventing protein aggregation. ❕Publication: nature.com/articles/s4159… ❕Press Release: biochem.mpg.de/structure-of-c… #Alzheimers @NatureSMB @PYusteCheca

New online! Structural analyses define the molecular basis of clusterin chaperone function bit.ly/47kDZ8k

Regulated proteolysis induces aberrant phase transition of biomolecular condensates into aggregates; a protective role for the chaperone Clusterin: sciencedirect.com/science/articl…

Very excited to share the structure and functional characterization of Clusterin, a key extracellular chaperone and apolipoprotein (ApoJ) linked to cancer, cardiovascular pathology and neurodegeneration. biorxiv.org/content/10.110…

Scientists from the Hartl Department show that the protein #Urm1 protects other proteins in cellular stress situations by promoting phase separation. ❕Publication: cell.com/cell/fulltext/… ❕Press release: biochem.mpg.de/urm1-protects-… @CellPressNews

Escucha a José Manuel Moreno (catedrático y miembro @IPCC_CH ) : “Quitar carriles-bici es una ideología de fanáticos y lunáticos que van a causar muertes”. Así, sin pelos en la lengua hoy en el Congreso de los Diputados

I am delighted to announce that my PhD work has finally been published, in which we uncovered a novel role for GCN1 in mitigating translational readthrough. #collision #readthrough #GCN1 @MPI_Biochem sciencedirect.com/science/articl… A thread. 🧵 1/18

A team led by Ulrich Hartl found out that the protein GCN1 helps to secure the "accident site" after two #ribosomes collided and calls other complexes to degrade the defective #mRNA @CellCellPress ❕ press release biochem.mpg.de/can-we-promote… ❕ full article cell.com/cell/fulltext/…

Dr. Paul Janssen, the founder of Janssen pharmaceutica (now J&J), was one of the most prolific drug discovery scientists ever. Between 1953-1991 Janssen and his team discovered >70 new medicines. I enjoyed this paper about his R&D philosophy: onlinelibrary.wiley.com/doi/abs/10.111…

At ADPD 2023, scientists showed that biosensor cell lines that detect tau seeds do make tau fibrils. A chaperone tears them apart. Does this happen in the #alzheimersdisease brain? @adpdnet @UTSWNews @MPI_Biochem @MRC_LMB ow.ly/4yyr50NEGeq

Joint Statement from German Postdoctoral Networks on the Eckpunktepapier from the BMBF postdocnet.mpg.de/127851/Stateme… with @MunichPostdoc @LeibnizPostDocs @Health_talents @FMP_MDC_PDA @PAW_Germany @SociedadCerfa @RedeApoena @awi_postdocteam and more. #WissZeitVG #ichbinhanna

Join us for a PhD in the Protein Biogenesis lab @TheCrick ! We have a very exciting project aimed at understanding how human cells orchestrate the folding of different proteins at the ribosome. crick.ac.uk/careers-study/…

The final version of our manuscript is now online: #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4146… Thanks so much to @Itikasaha and all our friends and collaborators that were part of this journey @ruferbus @IrinaDudanova @DavidWSanders2 @PYusteCheca

reflexiones tras asistir a oposición en @CSIC hoy: o se cambia el procedimiento decimónico de captación de talento del @CSIC o el @CSIC está abocado a desaparecer. Eso de asumir que los candidatos tiene absoluta disponibilidad corresponde a la época de los toros de Guisando

We are recruiting! My lab @TheCrick is looking for a postdoc with #cryoEM expertise, to help us understand how the ribosome and chaperones collaborate to catalyze protein folding.

Check out our latest review about the diverse functions of the extracellular chaperone Clusterin in the pathogenesis of neurodegenerative diseases doi.org/10.1002/bies.2…

Hoy la precariedad de los postdocs tiene un altavoz en ⁦@elpais_espana⁩ gracias a ⁦⁦@ElisaSilio⁩ . ⁦@CienciaGob⁩ , ⁦@UniversidadGob⁩ , es necesario actuar YA. ⁦@FJIprecarios⁩ ⁦@CientificoenEsp⁩ ⁦@postdoc_es⁩ elpais.com/educacion/univ…