Manav Pathania | @manavpathania.bsky.social

First Pathania Lab paper in @CD_AACR: bit.ly/3K5xA3J. We developed 16 mouse models of various subtypes of pediatric high-grade glioma— mirroring their different H3 mutant contexts, anatomical compartmentalizations and co-segregating partner alterations. Thread below 1/17

Lab summer social a few weeks ago in Oxford, during which we did some punting and played some darts

Sometimes I get an anonymous comment on my blog of someone sharing sad truth and it really sucks. One of my hopes for AI in science, and perhaps it's a naïve one, is that cases of sophistry such as described here are exposed more readily and broadly. #comment-26103" target="_blank" rel="nofollow noopener">liorpachter.wordpress.com/2025/06/16/rep…

Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. nature.com/articles/s4158… #immunology #cellbiology @immunox @ucsf

WOW!! Identification of a neural circuit that enables safe, long-term torpor in mice biorxiv.org/content/10.648…

CAR-neutrophils produced in vivo to treat glioma go.nature.com/4mOTMSI

We're looking for a Senior Computational Postdoc to help us analyse our single-cell, spatial and epigenomics data from mouse models and to cross-reference these analyses with data from human tumours. Please get in touch if you're interested! shorturl.at/yXwpC

Anthropic cofounder says studying the humanities will be ‘more important than ever’ and reveals what the AI company looks for when hiring fortune.com/2026/02/07/ant…

We're seeking to fill two roles: a PDRA and an RA. These positions will investigate resistance mechanisms in brain tumour models using in vivo models, spatial omics, CRISPR. Please apply if previous experience aligns! Here is the RA job advertisement: shorturl.at/NVl1V

We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience! shorturl.at/hZ6mG

As promised, here's the deep dive on our recent article! Did you know the brain's "sewer drains" (dural sinuses) aren't passive pipes—they're dynamic, ruffling structures that actively guard immunity & regulate pressure? As both a co-author and President & Founder of @neurosimplicity, I am excited to spotlight this groundbreaking discovery from the McGavern lab @NIH_NINDS in @Nature. Our Imaging Suite helped map the amazing cranial & neurovascular connections in unprecedented 3D detail! 🧠🔬 Link: rdcu.be/e4A8i #Neuroimmunology #BrainImmunity

Nature research paper: Highly dynamic dural sinuses support meningeal immunity go.nature.com/4qVnxlm

Nature research paper: A disease model resource reveals core principles of tissue-specific cancer evolution go.nature.com/4cIrt5i

Step 1: Insert bacteria ("Wolbachia") into mosquitoes. Step 2: Release mosquitoes. Step 3: Watch Dengue rates plummet. Phenomenal results from Singapore. Link: tinyurl.com/59c9t67u, by Lim et al.

I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth. This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF. biorxiv.org/content/10.648…

3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement cell.com/cell/fulltext/… cell.com/cell/fulltext/… cell.com/cell/fulltext/…

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵

Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below shorturl.at/x0cSs

Please share or forward to anyone interested in joining our lab for a postdoc, details can be found via the link below shorturl.at/GMbW0

Thanks to all those who helped us get going in Cambridge and looking forward to getting stuck in at Oxford soon!

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned! shorturl.at/thpyK