Peter F. Renz

@brkthroughprize Scientific achievements should be celebrated. But, by inviting people like Gwyneth Paltrow who is openly peddling pseudoscientific scams via goop, your award and the ceremony loses credibility.

Shining a light on the heroes of science that change our world 💡 Show premieres April 12 at 3pm EDT: youtu.be/on5LxZjRkA8 – the 11th Breakthrough Prize ceremony celebrated scientific achievements, honoring those driving remarkable discoveries in gene editing, human diseases, the search for the fundamental laws of the Universe and pure mathematics.

Fascinating work by @fabivf90 and @SendoelLab about the secret roles of microproteins

Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function. 1/9 biorxiv.org/content/10.110…

Spearheaded by the very talented @fabivf90 and another great collaboration with the Ellis lab, we used ribosome profiling to map microproteins in healthy epidermis and cancer, annotating more than 3000 novel ORFs. 2/9

interesting approach to look at clonal dynamics in cancer emergence. Particualrly impressed by the adoption of the Drake equation for cancer.

Goliath clades and in vivo tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis biorxiv.org/cgi/content/sh… #biorxiv_cancer

I was happy to contribute a small part to this very innovative work on single-cell translatomic changes in the aging epidermis led by the incredibly talented @clarasdure . Check it out

Congratulations to Peter (@PeterFRenz3) for being awarded the Skin Cancer Award 2024! Well deserved, we are very proud of you!

@AdrianoAguzzi @SandroAmbuehl I love a good conference, but business travel, especially by air, accounts for a large part of greenhouse gas emissions by universities (way more than 0.01%) see for example: sustainability.uzh.ch/en/campus-oper…

One of my favorite things about academia is that you get to travel to all these conferences and hang out and have fun with amazing people from all over the world. One of my least favorite things is that once the conference is over you don’t seem them again for months or years…

It was an honor and a pleasure to make a small contribution to help this lab grow. I'm sure the future is very bright for the Sendoel Lab.

It’s the end of an era as we bid a bittersweet farewell to @PeterFRenz3, one of the first members of our lab. Your commitment, spirit and enthusiasm have profoundly shaped our lab’s culture and have not only pushed scientific frontiers but also filled our days with lots of fun..

Thank you @CD_AACR for highlighting our recent paper. TNF Pathway Alterations Mediate Clonal Expansion and Tumorigenesis aacrjournals.org/cdnews/news/16…

@patrickruch @snsf_ch @snf_ch I know, but SNF has a lot of power/impact and could nudge universities in the right direction.

@PeterFRenz3 @snsf_ch Contracts are not managed by the @snf_ch but by universities.

New for doctoral students employed under SNSF funding schemes: we are increasing their minimum salaries. The measure will take effect on 1 January 2026. sohub.io/a55z

Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out @Nature, we identify distinct TNF programs during tumor evolution. 🧵 nature.com/articles/s4158…

Der Signalweg TNF-α steuert die Umwandlung von Epithelzellen in aggressive Tumorzellen. Die Erkenntnis einer UZH-Studie könnte die Früherkennung und Behandlung von Haut-, Speiseröhren-, Blasen- oder Dickdarmkrebs verbessern: news.uzh.ch/de/articles/me… @SendoelLab @uzh_irem

@CatharineAquino @FGCZ_EN @SendoelLab Billions of reads <3

Congratulations! We at @FGCZ_EN are happy to support this cool work! @SendoelLab @PeterFRenz3

The signaling pathway TNF-α drives the transformation of epithelial cells into aggressive tumor cells. This finding of a UZH study could help to improve early detection and treatment of cancers in skin, esophagus, bladder or colon: news.uzh.ch/en/articles/me… @SendoelLab @uzh_irem

@SendoelLab The most important lesson however? If you have with the support of awesome people, you can do great science even while being a dinosaur.

This work was spearheaded by the fantastic postdoc Peter Renz (@PeterFRenz3), the first postdoc in our young lab. He is also currently on the job market btw;) If you are interested in setting up an in vivo single-cell CRISPR approach for your model tissue, get in touch! 14/

The dark proteome encoded by more than 7200 annotated sORFs is redefining our understanding of the human genome. Interested in how to detect microproteins? Check out Fabiola's recent review "No country for old methods". sciencedirect.com/science/articl…