PlaNeT-2/MATISSE

The paper is here. @Ped_Research @ESPNIC @BritSocHaem @ASH_hematology @NIHR @eClinicalTrial #neonates #NICU #haematology #Clinicaltrials #PlaNeT2

LES ARTICLES IMMANQUABLES DE L’ANNÉE #Top5 sélectionné par la Commission Scientifique de la #SFN pour les #JFRN2019 @JAMAPediatrics @NEJM @TheLancet @ADC_FN bit.ly/36AeBce bit.ly/2qYeTue bit.ly/2syuWzv bit.ly/35ucC95 bit.ly/2PRLv1l

@EBNEO @PlaNeT2_trial Thank you for sharing. My little boy (23 weeks) had platelets a couple times, was then part of the trial but never required platelets after that! Have still got his little planet2 card that was on his incubator!

@EBNEO Always interested in knowing how the results of a trial impact the practice of those who conducted the trial. I mean, has anyone spent more time considering the implications? A take home point for me from this session: Anna Curley DOES NOT LIKE platelets. #HotTopicsNeo2019

What next for neonatal platelet research? - How fast should we give platelets? How much? Should they be ABO matched?

Why? What is the mechanism? #HotTopicsNeo2019 #neoEBM

Previous studies suggested that more platelet transfusions and more agressive threshholds were associated with poorer outcomes. #HotTopicsNeo2019 #neoEBM

Thrombocytopaenia affects 25% of NICU admissions, an important but under-researched topic. 15% of babies <1500g receive a platelet transfusion in the UK. The USA were, in 2011, even more liberal with platelet transfusions in preterm babies than some parts of Europe.

@PlaNeT2_trial “result suggests that adult platelets can have delayed adverse effects in very preterm infants by unknown mechanisms... “This trial reinforces the caution that deaths in trials of preterm infants may occur late and beyond the primary intervention.”

Moving on to platelets, Anna Curley co-Chief Investigator from @PlaNeT2_trial - effect of transfusion thresshold of 25 vs 50 on mortality or major bleeding in 1st 28 days in preterm infants #HotTopicsNeo2019 #neoEBM nejm.org/doi/10.1056/NE…

To measure bleeding outcomes, the @PlaNeT2_trial team developed the BAT - bleeding asessment tool #HotTopicsNeo2019 #neoEBM fn.bmj.com/content/98/3/F…

Primary and secondary outcomes of @PlaNeT2_trial - not just mortality and major haemorrhage improved in the platelet transfusion thresshold of 25 - but also BPD! #HotTopicsNeo2019 #neoEBM

@EBNEO Struck in initial read of @PlaNeT2_trial by time lag between differences in exposure (mostly trial day 1) & when you notice differences in death/bleeding (over a week out). Per Dr. Curley: adds to her suspicion that platelet-mediated harm is via inflammatory cascade. #neoEBM

Platelet transfusion threshholds: 25,000 even for the highest risk infants? neonatalresearch.org/2019/12/06/pla…

Fascinating talk from Dr Anna Curley @PlaNeT2_trial It all starts with asking the right question! @NeonatalUpdate @EBNEO #NeonatalUpdate2019

@FustoloSusanna @PlaNeT2_trial @bloodbankguy 🙏🏽Thanks, Susanna! @bloodbankguy is a master educator and we are lucky to have access to these #Blooducation experts. In fact, there is a recent podcast,BBGuy.org/072: Neonatal PLT Transfusion w/ Martha Sola-Visner on the @PlaNet2_trial --> twitter.com/HermelinMD/sta…

🎙️Dr. Joe Sweeney asks, "Does that patient REALLY need platelets?" on today's #BBGEssentials 🎧. PLT decisions can't JUST be about the number🔟. What else should you be asking? Free CE! BBGuy.org/078, Apple Podcasts, Google podcasts, etc. #blooducation #FOAMed 🅰️🅱️🆎🅾️

@FustoloSusanna @PlaNeT2_trial @ESteyerberg @Willem_Pieter @BloodJournal These important results are featuring in the December issue of ASH clinical news: ashclinicalnews.org/news/from-the-…

When should you give a preterm baby a platelet tranfusion? Join us at @NeonatalUpdate to hear Dr Anna Curley talk about evidence from @PlaNeT2_trial! @NNRDbase @imperialcollege @EBNEO @ESPR_EBN @BAPM_Official @NeonatalSociety #neoEBM #NeonatalUpdate

We're partnering w/ @NeonatalUpdate to share 2019 meeting highlights!  Head to London Nov 25-29 for a great lineup, including @CJStewart7 @NeenaModi1 @PlaNeT2_trial @AnalogAldo @oshea_jem @ToledanoMB & many others. Info: symposia.org.uk/neonatal/home.… #NeonatalUpdate #neoebm #ebneoad

A sneak peek at 6 of the 36 great sessions you will miss if you don't join @EBNeo at #HotTopicsNeo2019. Kiss the #fomo away & register today to hear @ravimpatelmd @PlaNET2_trial @NeoResearch_Net @NeenaModi1 @Stephenwpatrick & @hhburris in person: hottopicsinneonatology.org/Registration.h… #ebneoad