RaDVaC

Agentic AI for drug discovery is here! 🚀🧪🧑‍🔬 The @RADVACproject is interested in any tech that can accelerate the design of peptide-based vaccines. I just applied for early access. The focus here is antibodies & peptides, but I'm sure agents for small molecules are coming soon..

If this antiviral drug repurposing effort sounds interesting to you, please join us on Discord / reach out so we can keep in touch and maybe work together: discord.gg/Xu9b3CAK

...as therapeutics against a given virus, based on knowable properties of that virus, like its genome, proteome, corresponding host immunone and pathology.

As many of you know, the RaDVaC core team has been working both on articulating the biosecurity risks imposed by AI, and on AI's potential to increase biosecurity (tools weighted in a biosecurity-positive direction, rather than those capable of dual use and asymm. high risk).

Not all vaccines are created equal Some (like MMRV) actually do stop transmission - and do so for decades/life Other vaccines have weak if any protection against transmission and are shorter lived It has much more to do with the virus and how it replicates than the vaccine..

Do better. Vaccine access is essential for civilization.

Lots of biosecurity implications for AI (and many human failures already to ameliorate). Looking forward to the debate! Hope to see many of you there.

@JohnnyTStine Ideas are bulletproof. (Our community is most active on Discord: discord.gg/cA5Zhg8Xb3)

Where have all of the people at RadVac gone??? Did they get raided and threatened like I did????

Full article: medscape.com/viewarticle/fr… In a challenge test with hamsters, SARS-CoV-2 virus was not detected in nasal swabs of the vaccinated hamsters

Published today📣 Our nasal booster in the "Prime & Spike" vaccine works without adjuvants (which are needed to induce adaptive immunity but also cause inflammation). @Kwon_Dongil @tianyangmao @BenIsraelow et al. asked how this is possible. (1/) nature.com/articles/s4159…

Just out @Nature Nasal vaccines for respiratory infections Best review I've seen on this important topic and a big unmet need nature.com/articles/s4158…

endpts.com/vaccine-biotec… "...directed to stop their work for Project NextGen, a BARDA-funded initiative that was set to support planned 10,000-person Phase 2b trials testing their novel vaccines against currently approved vaccines"

The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @Nature nature.com/articles/s4158… nature.com/articles/d4158…

The need for better pandemic prevention & response is only growing. If your country just lost support for vaccine readiness, let's talk 🤙 reuters.com/business/healt…

Re @23andMe DOWNLOAD YOUR DATA! customercare.23andme.com/hc/en-us/artic… DO NOT follow deletion instructions from anyone who says to delete without downloading. If you delete without downloading your data will be gone permanently. And take a pause before you delete. I am not deleting my data from the company. There is enormous unrealized value in the data for biomedical research. And now that the obstructive and possessive CEO has resigned and is being increasingly disentangled from the company (thank you responsible board members!), it should be able to realize the promise of the data. #DownloadBeforeDeletion #23andme

AI Reasoning Virtual Shootout, Humans vs AI SERIES OVERVIEW: The Mind First Foundation has been very actively testing various AI models, including cloud-based frontier models as well as those small enough to be run locally. In order to make this engaging and fun, we will be posting a few queries each day followed by answers the next day. See how you do against various AI models! RATIONALE FOR THIS SERIES: AI models are typically tested across a range of benchmarks assessing abilities in math and coding, following instructions, and levels of expert knowledge in challenging STEM domains. Since these evaluation areas are well covered by others, we have focused on elementary reasoning and language comprehension, and we attempt to disentangle these to some degree from rote memorization, brute force exploration, and knowledge regurgitation. This has led us to create a set of queries that assess and reveal the limits of the abilities of both people and machines, wherein the answers can be understood by the average non-supergenius human. These tests help to get an intuitive sense (a vibe) of how smart these models really are relative to people, and allow you to experience the challenge. KEY POINT: Some of our queries are new variations on classic logic puzzles, wherein the answer to the classic puzzle is the wrong answer to the new variant. See how current frontier models perform on these queries (and please feel free to reply with variations of other classic brain teasers and simple logic puzzles). In this series we will post such pairs of classic (v1) queries and newly created (v2) queries, and show how frontier models score on these queries. A check mark (✓) indicates a correct answer and a minus sign (-) indicates an incorrect answer.

Premiering on YouTube today at 12pm Eastern: AI Safety Salon with Steve Omohundro (@steveom), featuring Preston Estep (@PrestonWEstep) and Dan Faggella (@danfaggella) at Microsoft NERD Center, with @HoekstraTweets and Astral Codex Ten Boston. Part 1: youtube.com/watch?v=J0jxkY…