RC

If you cannot listen to counterarguments and criticisms of your positions, consider them factually, and challenge yourself on what you know, then you are not a critical thinker: You are simply another member of the congregation of whatever belief system you have prescribed to.

8 years ago today... Childish Gambino — This Is America

I still vividly remember when this song came out and there was this weeks-long discourse about how the music video was supposedly an incredible work of art and deep cultural commentary about racism and gun violence in America. And it's literally just a black dude dancing around and shooting random people.

@KayBlockchain I'd throw some money at it.

CoinMarketCap reached out to me privately because I’m one of the selected traders invited to test and help train their new AI trading system before public launch. The idea is simple: turn a crypto trading strategy into an AI agent that can monitor the market and trade 24/7 based on defined rules. Not paid for this tweet, just curious: ▫️Would you use this kind of AI trading strategy tool?

@realJeremyCarl LOL at all of New Mexico 😂

I remember repeatedly arguing more than three decades ago in college that the Supreme Court’s interpretation of the Voting Rights Act creating majority minority districts was an unconstitutional Democrat gerrymander. (Yes, I was an elections nerd even then). Finally, we have overturned this injustice.

@DeanTTraining These, some shredded Mexican cheese, and the Costco Chipotle chicken *chef's kiss*

I wouldn’t go as far as to say that Mission Carb Balance tortillas are the greatest hack in the history of hacks but I would say they make the Top 20 list Maybe even top 10 tbh

"If quantum computers start breaking cryptography a few years from now, don't you dare come to this blog and tell me that I failed to warn you. This post is your warning." Newly elected member of the US National Academy of Sciences and quantum computing professor Scott Aaronson, writing on his blog today. Google and Coinbase, amongst many others, have recognised Algorand's leading post-quantum work. Our Chief Scientific Officer @ChrisPeikert helped create Falcon, a cryptographic algorithm selected by NIST as a global standard for quantum resistance, which we run in production on Algorand today. Quantum-secure chain history since 2022. Quantum-secure transactions and accounts since 2025. We heard the warning years ago.

Lowest tier: if I press the red button I live Midwit tier: I have to press the blue button because I cannot read Above average tier: I will press red because that’s the smart thing to do Smart tier: I will press the blue button because I understand the problem but I am also smart enough to realize not enough people understand the problem. By pressing the blue button and siding with the midwits, I can save them from their own stupidity. Genius tier: I will press the red button. I will survive and hopefully all the morons will die.

@joshscorcher I'd modify the caption for the red button in the left panel: "Nonzero chance of letting someone kill themselves."

Something I noticed.

@MarkoRaassina Wasn't expecting to cry this morning before heading to the gym, but well, here I am. Nice comic mate 💪🫂

(4/4)

Jock and his Grandpa (1/4)

Maher: “The president had the constitutional authority to direct the use of military force because he could reasonably determine that such use of force was in the national interest.” Schiff: “Totally vague.” Maher: “That’s from Obama about Libya.”

@bryan_johnson Very much looking forward to this one.

Just spent over an hour with my clinical team debating which growth hormone peptide protocol to run. Still torn. Wanted to share the thinking and get your take. The goal: Increase GH and IGF-1 to support anabolism, recovery, and sleep, but also test a specific stacking hypothesis. Tirzepatide (GLP-1/GIP agonist) can elevate resting heart rate, disrupt sleep, and suppress appetite aggressively. CJC-1295 (GHRH analog) can worsen insulin resistance. The bet is that combining them cancels each other's downsides: CJC-1295's slow-wave sleep enhancement offsets tirzepatide's sleep disruption, while tirzepatide's insulin-sensitizing effects counteract CJC-1295's insulin resistance. Best of both worlds — or at least, that's the hypothesis we're testing. The two candidates: CJC-1295 with DAC: the long acting version. One injection per week, stays active for 6–8 days. This is what was used in the actual clinical trials. Raises GH 2–10x and IGF-1 1.5–3x from a single dose. Preserves GH pulsatility even under continuous stimulation. The tradeoff: if you get side effects, you're committed for a week. Harder to titrate. CJC-1295 without DAC + ipamorelin: the short-acting version paired with a selective ghrelin receptor agonist. Daily injections, pre-bed, clears in 30 minutes. Ipamorelin adds a second axis of GH release, pulse frequency via the ghrelin pathway, on top of the amplitude boost from CJC. No cortisol or prolactin elevation. This is what most clinicians prescribe and most of the peptide community uses. The tradeoff: less clinical trial data, daily injections, more anecdotal evidence base. What we're considering: Start with DAC at half dose 2.4 mg, then if well tolerated escalate 4.8 mg, weekly injection. If side effects aren't tolerable, switch to no-DAC + ipamorelin (100 mcg then 200-300 mcg daily, before bedtime). Or, Run both head to head. 2 weeks DAC, 2 weeks no-DAC + ipamorelin and compare. Tracking: GH, IGF-1, Cortisol, CGM, real time core body temperature, RHR, overnight HRV (rMSSD), IGF-1, HOMA-IR, sleep architecture, subjective recovery. The purist in us says stick with DAC; that's where the published data lives. Yet the pragmatist says no-DAC + ipamorelin is what thousands of people actually use, and testing it generates more socially relevant data.

@bryan_johnson If I want to test certain markers more frequently, can I, and how much will that cost? Say, doing a comprehensive metabolic panel and testosterone on a weekly basis for more accurate tracking of markers when on an intense workout regime or when using peptides.

You can now get your blood work at cost. We launched a biomarkers testing platform. I make $0 on it. Blood testing needs to be more accessible. Instead, we wait until we get sick. And in the meantime, companies profit when you’re sick. It's messed up. > get tested > find what needs attention > implement protocols > test again Get ahead of unwelcome surprises.

@DeanTTraining Patiently waiting for this to show up at my local Costco.

Go to Costco Get yourself a bag of the Chargrilled Chipotle Seasoned Chicken Pop it in the air fryer Prosper YOU LITERALLY HAVE TO TRY NOT TO WIN IN 2026

@AlgoFamily @SlewCityNFT @nikitabier Nikita is a good guy, but seeing as he's an advisor for Solana, I have a hard time believing he's open to using Algorand. Would love to be wrong. He's a talented guy. Maybe he'll take a look, keep an open mind. I think there's a lot of use cases for @Algorand and @X.

@nikitabier Pls use a blockchain that works and 1, actually has high TPS capability unlike some that claim 65k but can’t even do 10% of that in smart contract TPS 2, is decentralized 3, quantum secure 4, Python and typescript programmable 5, atomic swaps on layer1 6, native assets= safer

Crypto has had a rough year. Maybe we should launch something to fix it.

@StaciW_DC @ChrisPeikert What cryptographic problems in general, and Algorand application specifically, keep @ChrisPeikert up at night? What is he most excited about tackling next, again both cryptographic wide, and Algorand specific?

Tomorrow I am doing a fireside chat with @ChrisPeikert on the quantum threat to blockchain. I thought it was a live Twitter space, but I just found out that it will be pre-recorded. Send me all of your questions! This is your chance to learn everything you ever wanted to know about post Quantum cryptography!

Sky full of stars. Following a successful lunar flyby, the Artemis II astronauts captured this breathtaking photo of our galaxy, the Milky Way, on April 7, 2026.

@emilyinvc Honest question: what is she looking for?

California now says they don’t have enough money to finish building their high-speed rail system and are asking for $125 billion more. CBS: “That’s more funding than Amtrak has received in its history, and still leaves a shortfall of roughly $90 billion.”

No one: Algorand after being mentioned 32 times by @Google in one of the most important papers on crypto security to date:

Looking forward to this discussion with Silvio!