Greg Huff

@SantiagoAuFund Central planning is impossible

They said the same about Yellen and Powell...

surest sign that hanta is over: it looks like the World Hobgoblin Organization needed a new marketing campaign.

@furst_fly @AlexanderKalian Can AI solve the three body problem?

@AlexanderKalian Same energy as claiming humans will never discover all laws of physics because earth is a tiny part of the universe

AI will never feasibly "solve" drug discovery. There are an estimated 10^63 possible small druggable molecules (1 followed by 63 zeros). To truly cover druggable biochemical space, AI would need to learn how all possible chemotypes causally interact across complex biological systems and multi-omics layers. Biochemical space is better thought of as a giant dense knowledge graph with 10^63 nodes. Even with extremely generous assumptions (e.g. one training sample informing the model about 1 trillion nearby related molecular nodes), you would still need 10^51 training examples. That alone breaks the scalability of any current or near-future AI architecture - as well as modern computers themselves. And this is before adding quantum-mechanical descriptors, physicochemical properties, pharmacokinetics, toxicological pathways, and all the other rich data layers. We currently have meaningful data on only ~10^8 molecules in open databases like PubChem - a tiny fraction of what would be required. And we haven't even discussed AI drug discovery's navigation of edge cases, larger druggable molecules, antibodies, nanoparticles, or chemical mixtures. Building the data required for a true "solution" is beyond human civilisation's capacity. We will possibly someday be an interstellar civilisation and still be working on stubborn pain points in AI drug discovery. That said, AI can still meaningfully improve drug discovery - generating better candidates, improving virtual screening, and modestly raising clinical success rates. That's valuable and worth pursuing. But a rigorous "solving" of drug discovery? Completely unfeasible.

@BigDickBarclay The bearings on this Studebaker I found in the woods today are still fine.

Less than a year old. All the oil has already leaked out and the bearings are going bad….

@LangmanVince Ok I guess Hillary Clinton was right about retards like you

Wow! Kyle Rittenhouse turned out to be a complete douchebag, we should've left him to the liberal wolves in 2020!

Grandma, I'm gonna be 2 hours and 35 minutes late to brunch today. Sorry, something came up.....

@misfitpatriot_ Make sure to wear your two masks and stay 6 feet away from people at all times

@Daniel_Spenrath Why can't Baltimore do this?

Garages are ugly. Duplexes are beautiful. Houston is one of the few cities that can pull this off

AI tits makes us want to click but not buy

@profplum99 Looking forward to meeting Bald Mike some day.

Fat Mike lives!

Long before Covid hit, Jerome Powell was saying that LOW inflation "was one of the major challenges of our time." Centimillionaire Powell restarted QE to bail out the banks in Sept. 2019, then led the Fed's idiotic ZIRP, QE, and "average inflation targeting" policies, which have given us unaffordable home prices, wealth inequality, and over 5 years of CPI-model pain well above the Fed's made-up 2% target. Under Powell's watch, a couple hundred million Americans have fallen further and further behind. Jerome Powell has been a complete disaster for everyone except the very wealthiest Americans (and sycophant WSJ reporters who profit off of ass-kissing books)

@TFTC21 Bioethics my ass. They should be charged with conspiracy to commit mass assault on the population. Actually, they deserve worse.

@AlGhouti2 @RizChuck77625 @pmtiegs @BreadedNeds suzuki.co.nz/suvs/overview/… Just move to New Zealand. They're everywhere.

@RealGregHuff @RizChuck77625 @pmtiegs @BreadedNeds If they did I’m pressing the BUY button instantly. Suzuki don’t make them anymore

Oh boy he’s in trouble

@RizChuck77625 @pmtiegs @BreadedNeds They still make them but you can't get them here :(

@pmtiegs @BreadedNeds Ahhh neat little vehicle. I like it

@JagexIsEpic @MonsierBones @mhp_guy

@MonsierBones @mhp_guy Is the nigganack a problem. I nigga never nigha did it before nigga

This guy makes six figures driving people across a bridge they're too scared to drive over themselves. He charges $40 cash. 10 to 30 clients a day. Some have been paying him daily for years. He meets them at a truck weigh station, hops in their car, drives them across in four minutes, and gets driven back by his assistant to do it again. The alternative route takes four hours through Baltimore. Here's what's wild... and possibly a little concerning: He said Airline pilots have used his service. His wife even makes custom eye masks that say "I hate this bridge." Steven Eskew has been running this business for years and has made tens of thousands of trips. I'll let you do that math. There's a business for everything. I promise you.

@BigDickBarclay Replace daylight savings with heat pump savings

@RudyHavenstein @ChristopherHale A gilded heifer

@ChristopherHale Isn't that a Golden idol?

NEW: MAGA evangelical leaders gather in Mar-a-Lago to bless and dedicate a gold statue dedicate to Donald Trump.

@jenstilmanydots Sponsored by $NEXT?

ICYI - Interactive Brokers offering a webinar on May 13 Noon ET 'If you think the last 10 years were transformative, this lays out why what comes next could be an order of magnitude bigger—and where to look before the market fully prices it in.' Link 👇 interactivebrokers.com/campus/webinar…

@bryanrbeal Must live pretty close to the airport?