Aaron Reinke

The lab’s latest preprint, led by @halatamim is now out! In this paper we characterize how bacteria associated with C. elegans impacts microsporidia infection by altering host metabolism and producing compounds that inactive microsporidia spores shorturl.at/3H9tO 1/8

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

“Don’t pick the wrong animals, it’s sad” #worm25

Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia biorxiv.org/content/10.110… #biorxiv_genomic

Butterfly populations across the U.S. are in alarming decline, according to a new Science study, with total abundance falling by 22% in just 20 years. Such widespread and worrisome losses portend broader environmental threats and emphasize the urgent need for conservation action. scim.ag/3FaRKdU

Very excited to see my first first author paper published in @PNASNews . We found the first effector regulator in plant-parasitic nematodes! Congratulations to all authors and co first author @ClemPellegrin. pnas.org/doi/10.1073/pn…

We are ready to recruit new postdocs to join our team at MPI Biology Tübingen! Please help us spread the words. Thank you!!! 😊

Marchantia polymorpha - as per its name occurs in many forms. We & many researchers have joined to study the genetic forms and adaptations of this liverwort led by Chloé Beaulieu, Pierre-Marc Delaux and Maxime Bonhomme @LRSV_Toulouse. nature.com/articles/s4158… Image @DavidJHoey

What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work science.org/doi/10.1126/sc…

Really cool work from @andy_utoronto! Converting metabolite abundance into barcode abundance with aptamers. Smol-seq is the best -seq!

This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:

So excited that our work on the first speciation gene pair in nematodes C. briggsae and C. nigoni finally got published on PNAS. It is really a tough but thrilling journey! It is just the beginning of the story of F-box genes, and I cannot wait to tackle the next one! Stay tuned

I am very skeptical of the AI/ML/computational methods to predict protein-protein interactions. Prove me wrong. I present a challenge for anyone who claims they can predict protein-protein interactions. 1/n

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.

Cool paper describing the discovery of bacteria that adhere to the intestinal cells of C. elegans biorxiv.org/content/10.110…

6 main figs and 5 supplementary figs .

Now that we're entering faculty job season, I want to reshare my ✨job search advice doc✨. It compiles all the super helpful advice I received from mentors & includes my own experiences on the market. Best of luck out there, everyone - you got this! 💪 helpimascientist.com/wp-content/upl…

Tenure track Professor of Teaching position open in my department. recruit.ucdavis.edu/JPF06676

@NKWhiteman This is a cool idea and here is an awesome example of this that MIT has been doing for a while. I went to a bunch of these In person while in grad school and they were super interesting and insightful. m.youtube.com/playlist?list=…

🤩Plz RT🤩 Assist/Assoc. Prof. Position job open at Lunenfeld/UofToronto in Computational #Virology/#Genomics. Toronto is reaching critical mass in #microbiology #bioinformatics Let's make it happen! #AcademicTwitter #AcademicCareer @FuturePI_Slack 🏹🎯 nature.com/naturecareers/…