Yuhe Renee Yang

New preprint! We report how a weakly binding antibody can nonetheless achieve potent neutralization via IgG-bridged virion aggregation. doi.org/10.1101/2025.1…

We are excited to share our latest work in @ScienceMagazine studying cooperative behavior in both biological and artificial intelligence systems — fantastic work by @JanineJiang22, Linfan Gu, and wonderful collaboration with @JonathanCKao! science.org/doi/10.1126/sc…

In a new @ScienceAdvances study, Scripps Research Prof. Andrew Ward (@WardLab1) and staff scientist James Ferguson describe a method that combines cryo-electron microscopy with the graphical neural network-based structure building tool, ModelAngelo, to identify monoclonal antibodies from polyclonal responses. This Structure-to-Sequence (STS) approach reduces the time needed to identify protective antibodies from weeks to under a day, offering a scalable method that minimizes data bottlenecks and accelerates therapeutic antibody discovery—critical for pandemic preparedness. More at: ow.ly/JLUv50WW1wU

Humanlike broadly neutralizing B cell lineages to influenza hemagglutinin are elicited in cynomolgus macaques by an influenza vaccine candidate science.org/doi/10.1126/sc… @ScienceTM

@biorxivpreprint Rapid elicitation of a new class of neutralizing N332-glycan independent V3-glycan antibodies against HIV-1 in nonhuman primates @TheWistar 🇺🇸 @EscolanoLab biorxiv.org/content/10.110…

New online! Computational design of sequence-specific DNA-binding proteins bit.ly/461bxaB

Two recent Science #Immunology studies provide insight into how different #COVID19 #vaccine types and dosing intervals affect T cell responses in humans. 📄: scim.ag/3HLLDOQ 📄: scim.ag/3JD7fgO

A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 @Nature 🇩🇪 nature.com/articles/s4158…

In a new #ScienceReview, researchers discuss the latest understanding of secondary organic aerosol formation in urban China, providing a framework for identifying knowledge gaps and guiding future research into haze chemistry and pollution control strategies. scim.ag/3HZJsHk

🎉 Excited to share our collabrative work—an all-in-one DNA matrix adjuvant platform. Composed of five unmodified, right-handed short DNA strands that self-assemble into a dynamic matrix at the injection site. nature.com/articles/s4155… @natBME

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postF specific binding and antigenic site I. Now published in @ACSPublications Infectious Diseases pubs.acs.org/doi/10.1021/ac… @Weiweipeng1992 @HaanXander @HangryHobbit

Working with symmetric or pseudosymmetric particles in #cryoEM? This TRPV5 and CaM case study includes practical considerations for using symmetry relaxation and 3D classification when analyzing a pseudosymmetric particle in #CryoSPARC!

An intranasally administered IgM protects against antigenically distinct subtypes of influenza A viruses nature.com/articles/s4146… @NatureComms

The Hangartner lab found that a higher ratio of antibodies to viral protein amplifies immune responses—triggering stronger activity from phagocytes & natural killer cells. Details in @CellReports show how antibody density influences immune cell activation. ow.ly/iiEn50VJSfG

🚀 We are actively recruiting Postdocs and Co-PIs! Exciting funded projects on DNA nanotags for single-particle cryo-EM and cryo-ET on going. International research experience preferred. 📷 yryanglab.com #Hiring #Postdoc #FacultyPositions pubs.acs.org/doi/10.1021/ja…

The emerging era of structural nanomedicine bit.ly/4cO80hz

@WeAreTandF @KUMCnews @MartinezSobrido @ReneeYuheYang @SVKuchipudi Congrats for your amazing work! 👏

📚Check most read recent papers of EMI in January – March 2025 : Read here: think.taylorandfrancis.com/most-read-rece… #EMI #Science #microbes #infections @WeAreTandF

Spatial multi-omics reveals cell-type-specific nuclear compartments @Nature @LongCai_Lab @yodai_takei nature.com/articles/s4158…

Investigating structures of biomolecules in their native context is challeneging. In situ cryo-electron tomography is making remarkable progress.