Rob Rousseau

@danielleobarber Cool paper Dan, well done to you and your team. S Fig 1h could be a new profile picture if you wanted to update it 😉.

So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB

We still don’t understand how T cells control tuberculosis. Our new paper shows that Mtb-specific T cells in NHP and human lung granulomas make many interesting effector molecules upon TCR stimulation. There’s a whole lot more to T cells in TB than IFNγ! cell.com/iscience/fullt…

We are looking to hire post-docs to work on T cell responses to M. tuberculosis infection using murine and NHP models. If you know T cells and wanna work on the top infectious killer check us out. The NIH intramural program is an amazing place!

Looking forward to our next #globalimmuno talk this Wednesday, March 26th, at 9am PST, noon EST, 4pm GMT by Dr. Marc Jenkins. Title: “The CD4+ T cell response to food: you aren't what you eat.” ZOOM LINK: ucsd.zoom.us/j/91053505061 LIVE ON YOUTUBE: @GLOBALIMMUNOTALKS" target="_blank" rel="nofollow noopener">youtube.com/@GLOBALIMMUNOT…

'That's what we need for TB' The Jenner Institute's (@VaccineTrials) Prof Helen McShane explains why the world urgently needs a vaccine for tuberculosis. #WorldTBDay

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

Listening to @joanneflynn19 talk about factors associated with protection against TB at @iuis_online

On #WorldTBDay2023 Spotlight celebrates some excellence in TB research. READ about Prof @McSheyson's journey from Cameroon to doing cutting-edge TB research at @UCTHealthSci. @SECTION27news @Novelchegou @satvi_uct @TBProof @LindaGailBekker @GmyworldG spotlightnsp.co.za/2023/03/24/fac…

Still looking for a few good post docs to join our group working on #TB #vaccines and immunology. Email me joanne@pitt.edu and please retweet. We are a fun group in #Pittsburgh @PittTweet !

2/2 There is an urgent need to invest resources to ramp up the fight against #TB & achieve the commitments to #EndTB made by global leaders. More investment will save millions more lives, accelerating the end of the TB epidemic.

Our new pre-print posted. We compare immune memory to Moderna, Pfizer, J&J, and Novavax COVID-19 vaccines head-to-head. T cells, B cells, and antibody. We think this is the most comprehensive immunological evaluation of these four different vaccines. 1/17 biorxiv.org/content/10.110…

1.There has been a lot of anticipation about Omicron and T cell responses. T cells epitopes are largely conserved and this suggest that most of the T cell response might still be on hand to fight the virus @Alba_Grifoni @aetarke @profshanecrotty @Dani6020 @ljiresearch

Positivity rate above 20% 🚩🚩🚩

To those q why our scientists made announcement. This is just 1 int scientists bringing these seq into public eye, with more alarm than SA scientists did, also lacking context. Tweets were before the presser! See no of followers EFD has & tell me we were going to keep this quiet?

Today, we shared positive pre-clinical data demonstrating our ability to combine 6 mRNAs against 3 different respiratory viruses in 1 vaccine: COVID-19 booster + Flu booster + RSV booster. #mRNA

@naledimashishi You should check with the specific institution you are applying for but some of them will accept the fact you have degree from most South African Universities as proof that you can speak/write in English.

Looking at masters programs for next year and I’m very annoyed at the number of universities that require me to take tests to prove I can speak English 😒 Can’t I just send them a copy of my book with a note saying “consider the following”

What about the B cells? Suraj Parihar & co show that "IL-4-responsive B cells are detrimental during the chronic phase of tuberculosis in mice with perturbed antibody profiles, inflammatory cytokines and tnf and stat1 levels in the lungs" #CIDRIPapers buff.ly/3exBLpW

1/Folks with mainly biology training sometimes ask me for resources that can help them learn bioinformatics. This short thread has my recommendations at various levels.