
Ron Conway
1.2K posts




I had one of the legends of angel and seed investing on Uncapped, @RonConway. He's the founder of SV Angel been an early backer of companies like Google, Facebook, Airbnb, and many more. We talked about the evolution of tech, being an actively involved investor, the power of being a relationship broker, fighting hard for founders, and some of his stronger feeling in politics. It was a pleasure to sit down with him. (Also fun to record a podcast episode at a live event, thank you TrueBridge) (0:00) Intro (1:50) From semiconductors to AI (8:39) Two investments that changed everything (11:46) Non-passive angel investing (14:57) Becoming a relationship broker (18:00) Building authentic relationships (24:48) Going deep with OpenAI and Airbnb (29:19) Fighting for founders (31:39) Remarkable returns at seed (33:20) The state wealth tax (37:17) Tech and politics

I support Ethan Agarwal against Ro Khanna Khanna has turned his back on the people of CA17. He said he would help tech, that his predecessor did nothing but name a post office. We would rather Khanna do that than work to destroy prosperity with national asset seizure.

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Today I’m launching @Valkyrie_vc - a $45M early-stage fund investing in AI, infrastructure, and critical industries. Grateful to the founders, partners, and friends I’ve worked with along the way. You’ve truly shaped how I invest and why I built Valkyrie. To the founders: Valkyrie was built for you. To partner with you. To build what matters. This is our new frontier. Let’s build it. Thank you to @_pheebini at @Forbes who captured the story → forbes.com/sites/phoebeli…

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As your mayor, my top priority every single day is keeping San Francisco safe. With the support of local law enforcement, community leaders, and the appropriate federal law enforcement partners, we’re achieving that goal without compromising our values or our laws. As a result, violent crime has fallen to levels not seen since the 1950s, tent encampments are at record lows, and for the first time in years, San Franciscans believe our city is moving in the right direction. There is no question we have more work to do. I ran for mayor because I see the impact of fentanyl use on our streets—when I drop my son off at school, when I talk to our business and community leaders, when I walk through the city in between meetings. My administration is working every day to make our city better. Our local law enforcement already has longstanding partnerships with state and federal law enforcement to shut down open-air drug markets through our Drug Market Agency Coordination Center. To continue getting fentanyl off the street, we would welcome stronger coordination with the FBI, DEA, ATF, and U.S. Attorney to execute targeted operations, arrest drug dealers, and disrupt drug markets and multinational cartels. I trust our police officers, sheriff’s deputies, and district attorney to work together to keep our city safe—and with the right coordinated support from our state and federal partners they will have the tools to advance this critical work. I am deeply grateful to the members of our military for their service to our country, but the National Guard does not have the authority to arrest drug dealers—and sending them to San Francisco will do nothing to get fentanyl off the streets or make our city safer. Under my leadership, we will always protect the people and the values that make San Francisco the greatest city in the world. That means welcoming people in our city and standing up for every member of our community and for the longstanding policies that have kept our communities safe. As your mayor, that has been and always will be my north star.


Today, @ekindogus and I are excited to introduce @periodiclabs. Our goal is to create an AI scientist. Science works by conjecturing how the world might be, running experiments, and learning from the results. Intelligence is necessary, but not sufficient. New knowledge is created when ideas are found to be consistent with reality. And so, at Periodic, we are building AI scientists and the autonomous laboratories for them to operate. Until now, scientific AI advances have come from models trained on the internet. But despite its vastness — it’s still finite (estimates are ~10T text tokens where one English word may be 1-2 tokens). And in recent years the best frontier AI models have fully exhausted it. Researchers seek better use of this data, but as any scientist knows: though re-reading a textbook may give new insights, they eventually need to try their idea to see if it holds. Autonomous labs are central to our strategy. They provide huge amounts of high-quality data (each experiment can produce GBs of data!) that exists nowhere else. They generate valuable negative results which are seldom published. But most importantly, they give our AI scientists the tools to act. We’re starting in the physical sciences. Technological progress is limited by our ability to design the physical world. We’re starting here because experiments have high signal-to-noise and are (relatively) fast, physical simulations effectively model many systems, but more broadly, physics is a verifiable environment. AI has progressed fastest in domains with data and verifiable results - for example, in math and code. Here, nature is the RL environment. One of our goals is to discover superconductors that work at higher temperatures than today's materials. Significant advances could help us create next-generation transportation and build power grids with minimal losses. But this is just one example — if we can automate materials design, we have the potential to accelerate Moore’s Law, space travel, and nuclear fusion. We’re also working to deploy our solutions with industry. As an example, we're helping a semiconductor manufacturer that is facing issues with heat dissipation on their chips. We’re training custom agents for their engineers and researchers to make sense of their experimental data in order to iterate faster. Our founding team co-created ChatGPT, DeepMind’s GNoME, OpenAI’s Operator (now Agent), the neural attention mechanism, MatterGen; have scaled autonomous physics labs; and have contributed to some of the most important materials discoveries of the last decade. We’ve come together to scale up and reimagine how science is done. We’re fortunate to be backed by investors who share our vision, including @a16z who led our $300M round, as well as @Felicis, DST Global, NVentures (NVIDIA’s venture capital arm), @Accel and individuals including @JeffBezos , @eladgil , @ericschmidt, and @JeffDean. Their support will help us grow our team, scale our labs, and develop the first generation of AI scientists.

Finally, I get to share this with the world! Cash flow keeps business owners up at night. That’s why I couldn’t be more excited about this launch. Today, we’re introducing 🔥 Gusto Money 🔥 —a suite of tools that gives small businesses the clearest view of their finances yet. We also unveiled: - Instant Pay for 24/7 payroll - Level-funded health plans that save ~20% - Gusto HR Partners for on-demand HR expertise - Payroll Hub to help accountants work faster This Showcase goes beyond features—it’s about giving small businesses control and confidence.
