Prof Ros Gleadow FAA

Here’s the recording of my talk for @GlobalPlantGPC on my personal journey in science - the QandA ended up being a career advice session. Frank and personal.

Great win early in the year to receive notification that our case series looking into Dr Pridgen’s Valacyclovir, Celecoxib and Paxlovid protocol seems to really help some folks with #LongCOVID. This paper is a start, not the be-all and end-all: frontiersin.org/journals/immun… 1/

🌍 Free, self-paced education for people with #MECFS, #LongCOVID and other energy-limiting conditions. Our new Learning & Education Centre with Bateman Horne Center covers PEM, pacing, orthostatic intolerance + daily life strategies. Start here: zurl.co/Qm1EB

Excessive cutting back of nature strips’ tree canopy contributes to urban heat islands, damages trees, goes against expert advice, and costs ratepayers millions of dollars. The Allan state govt needs to drop its evidence-free red tape and wind back regulations on suburban tree pruning. theage.com.au/national/victo…

The Health Impacts of CO2 While the health risks of outdoor air pollution are widely acknowledged, the dangers of poor indoor air quality often go unnoticed. airspothealth.myshopify.com/a/blog/the-hea…

In 2023, a Uni of Tasmania study found #mecfs costs Aussie society up to $10bn/year - yet our govt continues to ignore the need to fund biomedical research. Talk about false economy❗️ @Mark_Butler_MP @Mon4Kooyong @SenatorJordon @natasha__may @real_EvanYoung

Vascular Complications of Long COVID—From Endothelial Dysfunction to Systemic Thrombosis 🔥 And again, now an interesting Serbian systematic narrative review synthesizing current evidence on vascular dysfunction, coagulopathy, and thromboembolic complications associated with post-acute sequelae of SARS-CoV-2 infection: #LC ➡️"LC has emerged as a complex multisystem condition in which persistent vascular dysfunction appears to represent a key pathogenic component." ➡️"Chronic inflammation, immune dysregulation, endothelial injury, and sustained activation of coagulation pathways collectively contribute to the development of microvascular and macrovascular abnormalities long after the resolution of acute infection." ➡️"Mechanisms such as endotheliitis, activation of the complement cascade, formation of fibrinolysis-resistant microclots, platelet hyperactivation, and involvement of the autonomic nervous system promote impaired perfusion, tissue hypoxia, and a broad spectrum of clinical manifestations. Microvascular rarefaction, capillary dilatation, microhemorrhages, and reduced flow-mediated responses have been widely documented and correlate with neurological, cardiovascular, and acral symptoms observed in patients with LC." ➡️Clinical Risks: - Increased incidence of venous thromboembolism (DVT, PE; hazard ratios up to 2.93), - Arterial events (MI, Stroke; up to 3.16), - Arrhythmias, - Myocarditis, and - Heart failure, - Risks persisting up to at least 1 year post-infection, especially in severe cases or high-risk groups, but even MILD cases can carry these risks!. ➡️"Growing evidence suggests that the vascular component provides a unifying framework linking many of the persistent symptoms and complications associated with LC." ➡️"A deeper understanding of these interconnected mechanisms is essential for early recognition, risk stratification, and individualized management of affected patients." ➡️"Further research is needed to identify reliable biomarkers, determine individuals at greatest risk, and develop effective therapeutic strategies aimed at supporting endothelial recovery, modulating immune activation, and restoring microcirculatory function." ➡️"Future interventional studies should clarify whether therapies targeting endothelial repair, microthrombotic burden, or autonomic imbalance can modify the long-term trajectory of LC, ideally within multidisciplinary care pathways involving cardiology, hematology, neurology, and rehabilitation services." ‼️So, for those sitting at the back, Long COVID drives persistent vascular complications through SARS-CoV-2-induced endothelial dysfunction and thromboinflammation, markedly elevating risks of thrombosis, stroke, myocardial infarction, and heart failure for at least one year post-infection! ‼️Awaiting studies on multiple infections, with the added/cumulative risks from these reinfections. ‼️Meanwhile this review AGAIN emphasizes endothelial dysfunction as the pathophysiological link driving long-term vascular morbidity in LC! mdpi.com/1422-0067/27/1…

@DrShaneRRR I heard Academia in its worst form likened to a cult

Worth reading 👇👇

As we bid farewell to another year, let’s remember Lily and the 600,000 people living with #MECFS or #longCOVID. Help #PowerOurPractitioners so more can access better care. Donate: zurl.co/C3awr

Here's my "2025 - Year in Review". I'm really looking forward to 2026! My New Years Resolution: make more folders. youtube.com/watch?v=ctTQBX…

Time to switch off the socials for my annual Digital Detox - might not come back

@fitterhappierAJ My last infection was 3 weeks post vaccination. I took antivirals and was not nearly as sick as last time - but 10 days later was exhausted for about a month. I rested and took everything I could think of to reduce the risk of LC. Feeling good now 3 months later 🤞

Wonderful descriptive depiction. One take-home is that if you are getting infections despite vaccination, there is an evident, and high chance of long covid manifestation in bodily systems I will make a thread on the charlatans who said long covid was less than 5% later

@baldypidge I’ll look it up

@RosGleadow True. Prof, there's also a terrific new film that you might enjoy, by Grant Wakefield. vimeo.com/1148425617

Too true to be funny - many apply to climate change denial too

“ME/CFS is maybe one of the only areas of research and clinical practice where you can be accused of “advocating“ just for following the data.”

I find that people interviewing me are surprised when I, as a clinician-scholar am very plain about fairly non-controversial items like “ME is complex and verifiably biological” and “ME is not deconditioning” and “ME ruins lives.” These things, at least, are settled science.

Why scientists are rethinking the immune effects of SARS-CoV-2 « A growing number of scientists believe that the SARS-CoV-2 virus may instead be subtly altering our immune systems » The proof is all around us … bmj.com/content/390/bm…

excellent word!

My local member 👏

📢📰🌱🌾🌱 A huge achievement for innovation in #plantbreeding! EU Member States endorsed the agreement on #NewGenomicTechniques, supporting innovation, resilient crops and a competitive seed sector. Take a look at the reaction of our Secretary General & CEO, Garlich von Essen ⬇️ Read more 👉 tinyurl.com/yn6dcw5s #GrowingTheFuture #NewGenomicTechniques #seedinnovations

📢🌱📈 Postdoc opportunity at @UQ_News, @QAAFI We’re hiring a postdoc to work at the interface of Crop Modelling & Physiology & #Photosynthesis & Crop Improvement. Job description and apply here: tinyurl.com/54rcwkt6 CI Wu: tinyurl.com/595t98wa