Dr Sam Washer

I am thrilled to announce that my first, first-author publication from my PhD journey is now finally live on bioRxiv! biorxiv.org/content/10.110… 🥳🍾👏🎉 In this work, we used iPS-microglia to create a ‘’Everything you ever wanted to know about human microglial reaction to tau…’’

👋 switching over to bsky, give me a follow for more microglial antics bsky.app/profile/swashe…

We're back in the studio today, recording a podcast with @nottalexi @Josiaharvey @sj_marzi @SamWasher2 & hosted by @FHMcLean. Can you guess the topic?

@javier_gilbert Brothers in science, brothers in cell lines 😂

@SamWasher2 I'm using the 2.1J 🤣🍻

Wednesday cellfie: KOLF2.1S iPSC microglial + neuron co-cultures, so pretty😍What's not shown is the pain of optimizing these conditions... Hopefully these models can help us further understand the molecular basis of Alzheimer's disease🧠 #ForACure

If you are at #ADPD2024 in Lisbon come see our posters of our studies of DNA methylation meta-analyses in Lewy body disease led by @Josiaharvey and @Jenny_Imm, and spatial transcriptomics in the J20 amyloid model led by @millie_sander

Excited to see this work from my Postdoc in Andrew Bassett's lab at @sangerinstitute finally out in the world! biorxiv.org/content/10.110… we found an AD-associated variant in PTK2B that actually has a causal effect on chromatin accessibility, gene expression and microglial function

Microglia NLRP3 inflammasome 'DUBbed' by UCH-L1 @Zhu_L_Oxford @AndreasDamiano2 @flassen_ @ProteomOX @TaoDongGroup @theRafLab @TateScience @CmdOxford @CAMS_COI_Ox @ARUK_ODDI @KirOxford @bdi_oxford @HumanGeneticsOx @Dunn_School @NDMOxford biorxiv.org/content/10.110…

Come hear @MartaP4lcantara presenting on how we're mapping sceQTLs in iPSC-derived microglia to interpret neurodegeneration GWAS variants. Starting soon: 11:45am Ballroom A. A collaboration with @OpenTargets #ASHG2023

Some superb talks today around neuroinflammation in Alzheimer's Disease at #AAIC23 So don't miss out on the chance to come and chat all things iPSC microglia and CRISPR screening with me at poster 111 🧬🔬

1 in 3 names are missing on the #Lionesses shirts tonight, representing the 1 in 3 of us born in the UK today who will develop dementia. Tonight’s match was dedicated to @alzheimerssoc, raising vital funds to those devastated by dementia. Donate now: alzheimers.org.uk 👈

Congratulatuons Rebecca! And thanks so much to the panel, always a pleasure to talk about my work. Thanks to the PDA organisers for a great day of science 👨🏼‍🔬

Excited to share that this work is now out in Scientific Reports 🥳Give it a read, download, share! nature.com/articles/s4159…

#DataScience #PhD opportunity for quantitative student looking to apply their skills to big biological datasets. Be part of the @GW4BioMedDTP @ExeterMed and @PsyEpigenetics exploring methods to computationally derive cell-type specific epigenetic profiles to understand

Position available at @ExeterMed to work with on alternative splicing and epigenetic modifications in models of Alzheimer's disease pathology. @ExeterNeuro jobs.exeter.ac.uk/hrpr_webrecrui… Please RT!

This has been a huge volume of work with lots of challenges but a big thanks to everyone involved at University of Oxford (Sally/@WilliamSiwJames) and the Wellcome Sanger Institute (Yixi, Marta, Juliette, Andrew), and for @OpenTargets for funding the work!

Finally, we show that the microglia cultured in ITMG show similar phagocytic capacity to our old media for Amyloid beta, 448 labelled silica beads, and a novel dead neuron traffic light assay for autophagy. Showing they retain this core function

Thrilled to share our latest preprint on iPSC microglia differentiation. If you have been using the Haenseler et al 2017 protocol then you'll want to check out this update from the Cowley lab biorxiv.org/content/10.110… 1/n