Alessandro Chesser

We spent 3 years working on this. What used to cost $100k+ and take months… now costs $1,500 and can be done in less than 24 hours. My cofounders and I all met at Carta in 2014. Kyle was the 1st engineer, I was the 1st sales hire, and Edison the 1st PM. We saw 1st hand that the richest people put their startup shares into trusts for family/friends and assumed they did it because they were just being generous. Well that might be the case, but we also found out that each trust was saving them millions in taxes. The richest people were paying zero taxes and the rest of us giving up nearly half our earnings. The system is completely broken - so we fixed it. Starting today, the earliest stage founders can set up the exact same trusts billionaires use, from day one of incorporation. Day 1 is the best time to put your shares in a trust, because the shares are worth zero on day 1. The less your shares are worth, the more taxes you can save. Check us out! @getdynasty_com And help us keep more hard earned money in the hands of founders and early employees.

@btcjammer @Dynastus There are all different types of Suburbs. Some are more spaced out like this

@SandroChess @Dynastus If you look at this picture and think “basically the same as modern-day suburbs” - I don’t really know what to tell you

Reject the single family home. Embrace the family compound.

Congrats @davj and the @fondocom team on the launch. Startup founders: if you don’t have help with taxes yet, check this out.

@rabois We spend all our time engineering network effects instead of hiring sales reps. Could care less about building the fastest trust company… because our plan is to be “the last” trust company.

The AI era will not be friendly to startups who chased revenue traction at the expense of accumulating advantages (or 7 Powers).

When you’re 5 years old, a year is 20% of your life. And when you’re 50 years old, a year is 2% of your life. This is an explanation given why time speeds up as you age. It's called Janet's law. It states you’ve experienced roughly half of your perceived by life by 20 years old. Or to put it another way: A summer holiday for a 5 year old feels as long as the 10 years from 40 to 50 years old. But Janet's law can be broken with high agency. You have agency over the speed time. You're not a passive victim. A better explanation of why time speeds up as you age is because you have fewer new experiences as an adult, so your brain deletes the memories. If you take agency over your life, do new things and create memory dividends, time slows down. If you live your life on autopilot, you may die at 80, but feel like you died at 20 years old. If you take agency over your life, you may diet at 80, but feel like you died at 200 years old.

7.1 earthquake will hit Southern California between Los Angeles and the Salton Sea - during the next 36 hours ! - Please prepare your home and family.

@hattra2 @DrNeilStone I don’t think you understand. Doctors and hospitals have their own reporting system. The only system they rely on. And yes it was not reported there

@SandroChess @DrNeilStone SO it has been reported You claimed that it had "gone unreported" Are you lying now, or were you lying then?

No vaccine causes cancer The HPV vaccine prevents cancer Vaccines are in development to treat cancer Thank you Have a great day

@hattra2 @DrNeilStone Yes

@SandroChess @DrNeilStone On VAERS?

@hattra2 @DrNeilStone I did actually report it but my point is nobody cares. That is a poor argument against the fact that the institutions who say Valera can’t be trusted won’t report it themselves

@SandroChess @DrNeilStone So I say again - what stopped you logging onto VAERS and reporting it yourself?

@hattra2 @DrNeilStone Who said anything about anti vaxxer. I brought my child to get his vaccine and he had a severe neurological reaction. You are creating straw man arguments

@SandroChess @DrNeilStone So anti-vaxxers point to VAERS as evidence of vaccine harm, but simultaneously think it can't be relied on, because anti-vaxxers post fake reports? Make it make sense

@hattra2 @DrNeilStone Why bother when all the scientists and doctors say it can’t be trusted because it’s self reported

@SandroChess @DrNeilStone So what stopped you logging onto VAERS and reporting it yourself?

@TurnerNovak Sandwich as a service

SaaS is not dead

A cancer patient stops responding to immunotherapy. Nothing else is working. Then they receive a fecal transplant from a healthy donor. And over half start responding again. Not from a new drug. From bacteria. I wrote about this recently because it's something we've been doing at Williams Cancer Institute for a while now. We were among the first clinics to use fecal microbiota transplantation as a cancer therapeutic, not just for C. difficile, but as part of our immunotherapy approach. And the science continues to validate what we've been seeing in our patients. The gut microbiome is the beating heart of the immune system. That's something I've believed for a long time, and the research keeps reinforcing it. Studies have shown that specific bacteria, particularly Bifidobacterium longum and breve, are essential for checkpoint inhibitors like Keytruda and Opdivo to function properly. And data presented at ASCO-SITC revealed that patients given antibiotics within one month of starting immunotherapy had a median survival of just 2 months, compared to 26 months without prior antibiotic exposure. Think about that. The most advanced cancer drugs we have may not reach their full potential if the microbiome isn't supported. And standard probiotics alone don't solve it. Research actually suggests they can reduce the microbial diversity that matters most. FMT is the only therapy that has been shown to truly restore gut microbiota populations. That's why we believe in it, and why we're retrospectively studying how the fecal transplants we've already performed have impacted our patients' survival alongside their immunotherapy. What excites me most is how this connects to something bigger. I've been developing a framework I call the Duality Theory. It's the idea that cancer and aging aren't separate problems. They're two manifestations of the same underlying process: immune system dysfunction. Both involve cells, whether cancerous or senescent, that have learned to evade immune clearance. They hijack the system meant to eliminate them, and they corrupt everything around them. As we age, our microbiomes degenerate, leading to chronic inflammation, accumulation of senescent cells, and a weakened immune response. This creates the perfect environment for cancer to take hold. A fecal transplant from a younger, healthier donor doesn't just introduce good bacteria. It may deliver rejuvenation factors that help shift the immune system toward a younger, more functional state. I believe that if we can get the microbiome right, even without immunotherapy, we could potentially prevent cancer in many people. That could save tens of thousands of lives a year. It's something worth paying attention to. The future of cancer care isn't just about finding better drugs. It's about understanding that your body is an ecosystem, and healing starts from within.

AI is cool, but when are we going to cure cancer? Cancer deaths are up 70% since 1990. Is it too hard of a problem to solve? Or do we just need more of the smartest minds (and compute) focused on it?

Please don’t let @CAgovernor become president. He’s destroying California. Anyone but him.

@katiekirsch My favorite hotel in the world right there

75 degrees in Big Sur this weekend 🥹

“You attract mercenaries not missionaries” This is so important but rarely gets talked about. Hiring mercenaries is the best way to kill a startup

AI is going to solve this. Birth rates are collapsing because people care more about their career than having kids. AI will take all the jobs and we will get back to just having kids again.

@anothercohen This happened to us also. Copied our website, business model, and pricing word for word. Almost did a YC hate post about it

This gets even worse. I got access today to the investment memo from their seed round two months ago (the startup is Paratus Health). Every single stat is made up on their website. Straight up lying about conversation volume and number of clinic partners. Low integrity founders